Zobrazeno 1 - 9
of 9
pro vyhledávání: '"M. Kyle Hadden"'
Autor:
Jiachen Wen, Radha Charan Dash, Angela M. Zaino, Noah J. Harrahill, Jackson T. Calhoun, Christopher O. Dusek, Shana R. Morel, Matthew Russolillo, M. Kyle Hadden
Publikováno v:
Bioorganic Chemistry. 132:106387
Publikováno v:
European Journal of Medicinal Chemistry. 162:495-506
The Hedgehog (Hh) pathway is a developmental pathway with therapeutic potential as a target for a variety of cancers. In recent years, several vitamin D-based compounds have been identified as potent inhibitors of Hh signaling. These analogues contai
Autor:
Jiachen Wen, M. Kyle Hadden
Publikováno v:
Eur J Med Chem
Medulloblastoma (MB) is the most common malignant brain tumor in children. Current treatment for MB includes surgical resection, radiotherapy and chemotherapy. Despite significant progress in its management, a portion of children relapse and tumor re
Exploring the physicochemical and antiproliferative properties of biaryl-linked [13]-macrodilactones
Autor:
Angela M. Zaino, Cristin Bosko, Mark W. Peczuh, Ryan McLean, M. Kyle Hadden, Chengsheng Chen, Catherine P. McGeough
Publikováno v:
Bioorganic & Medicinal Chemistry. 28:115671
A macrocyclic motif fosters productive protein-small molecule interactions. There are numerous examples of both natural product and designed, synthetic macrocycles that modulate the immune system, slow microbial infection, or kill eukaryotic cells. R
Publikováno v:
Bioorg Med Chem Lett
Dysregulation of the hedgehog (Hh) signaling pathway is associated with cancer occurrence and development in various malignancies. Previous structure-activity relationships (SAR) studies have provided potent Itraconazole (ITZ) analogues as Hh pathway
Autor:
M. Kyle Hadden, Daniel DeCarlo
Publikováno v:
European Journal of Medicinal Chemistry. 56:179-194
Increasing studies show that methylation of histone lysine residues is implicated in the development and progression of varying disease states such as schizophrenia, diabetes, and multiple human cancers. Targeting the specific enzymes responsible for
Publikováno v:
Bioorganic & Medicinal Chemistry. 17:634-640
High-throughput screening of a library of diverse molecules has identified the 1,4-naphthoquinone scaffold as a new class of Hsp90 inhibitors. The synthesis and evaluation of a rationally-designed series of analogues containing the naphthoquinone cor
Autor:
M. Kyle Hadden, Brian S. J. Blagg
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 17:5063-5067
Small molecules based upon natural product dimers that exhibit cytotoxic activity were synthesized and evaluated for their anti-proliferative activity in human breast cancer cell lines. A central isophthalic core structure linking aromatic amines con
Autor:
Brian S. J. Blagg, M. Kyle Hadden, Bo Geon Yun, Robert L. Matts, Zeqiang Ma, Lakshmi Galam, Qi Zhuang Ye
Publikováno v:
Bioorganic & Medicinal Chemistry. 15:1939-1946
Previously, we have demonstrated that the renaturation of heat denatured firefly luciferase is dependent upon the activity of Hsp90 in rabbit reticulocyte lysate. Here, we demonstrate that this assay may identify inhibitors that obstruct the chaperon