Zobrazeno 1 - 10
of 192
pro vyhledávání: '"Kevin J Harrington"'
Autor:
Kate Newbold, D. McQuaid, Kevin J. Harrington, Amit Gupta, H. Barnes, Shreerang Bhide, KH Wong, Simeon Nill, Uwe Oelfke, Christopher M. Nutting, Alex Dunlop, A. Mitchell
Publikováno v:
Clinical and Translational Radiation Oncology, Vol 32, Iss, Pp 48-51 (2022)
Clinical and Translational Radiation Oncology
Clinical and Translational Radiation Oncology
Highlights • The MR-Linac provides the tools to deliver online MR-guided Adaptive Radiotherapy • Adapt-to-Shape-Lite is a novel radiotherapy planning workflow on the Elekta Unity MR-Linac • Adapt-to-Shape-Lite generated plans that fulfilled 99.
Autor:
Clifton D. Fuller, Baukelien van Triest, Bruce D. Minsky, Rob H N Tijssen, Joel W. Goldwein, Stella Mook, Kevin J. Harrington, John P. Christodouleas, Uulke A. van der Heide, Robert Huddart, Ananya Choudhury, Kristina Orrling, Sophie R de Mol van Otterloo, Robbert J.H.A. Tersteeg, Susan Lalondrelle, Dave Eggert, Anna M. Kirby, Chia-Lin Tseng, Beth Erickson, Uwe Oelfke, Hafid Akhiat, Marlies E. Nowee, K.J. Brown, Claire McCann, Corinne Faivre-Finn, Erwin L. A. Blezer, Emma Hall, Lois A. Daamen, Helena M. Verkooijen, Martijn Intven, Christopher J. Schultz, Alison Tree, Shaista Hafeez, Marielle E.P. Philippens, Arjun Sahgal, William A. Hall
Publikováno v:
Int J Radiat Oncol Biol Phys
International Journal of Radiation Oncology-Biology-Physics, 111(4), 867-875. ELSEVIER SCIENCE INC
International Journal of Radiation Oncology-Biology-Physics, 111(4), 867-875. ELSEVIER SCIENCE INC
Purpose: High-field magnetic resonance-linear accelerators (MR-Linacs), linear accelerators combined with a diagnostic magnetic resonance imaging (MRI) scanner and online adaptive workflow, potentially give rise to novel online anatomic and response
Autor:
Dorothy M. Gujral, Kevin J. Harrington, Win Soe, Aisha Miah, M. Emson, David Bernstein, Katie Wood, James P Morden, Amen Sibtain, Matthew Beasley, Deborah Gardiner, Nachi Palaniappan, Audrey Cook, Teresa Guerrero Urbano, Shelia Fisher, Tom Roques, M. Rizwanullah, Mehmet Sen, Paul Sanghera, Emma Hall, Christopher D Scrase, Vivian P Cosgrove, Christopher M. Nutting, Clare Griffin, Shanmugasundaram Ramkumar, Elizabeth Junor, Shreerang Bhide, Catherine M West, Bernadette Foran, Hisham Mehanna
Publikováno v:
European Journal of Cancer. 153:242-256
Background Radical (chemo)radiotherapy offers potentially curative treatment for patients with locally advanced laryngeal or hypopharyngeal cancer. We aimed to show that dose-escalated intensity-modulated radiotherapy (DE-IMRT) improved locoregional
Autor:
M Dvorkin, Jean Bourhis, Antonio Rueda, Amanda Psyrri, József Lövey, Robert L. Ferris, Holger Thurm, Steven De Beukelaer, Mohammad Abdul Razaq, Kevin J. Harrington, Chaosu Hu, Lara Dunn, Jin-Ching Lin, Ezra E.W. Cohen, Makoto Tahara, Robert I. Haddad, Nancy Y. Lee, Dmitri Pavlov, Peter Mu Hsin Chang, Maria Margarida Teixeira, Jerome Chamois
Publikováno v:
The Lancet Oncology. 22:450-462
Summary Background Chemoradiotherapy is the standard of care for unresected locally advanced squamous cell carcinoma of the head and neck. We aimed to assess if addition of avelumab (anti-PD-L1) to chemoradiotherapy could improve treatment outcomes f
Autor:
M. Denyer, Nicola E. Annels, Guy Simpson, Kevin J. Harrington, Richard G. Vile, Mehreen Arif, Hardev Pandha, Alan Melcher, Matthew C. Coffey
Publikováno v:
Molecular Therapy Oncolytics
Molecular Therapy: Oncolytics, Vol 20, Iss, Pp 434-446 (2021)
Molecular Therapy: Oncolytics, Vol 20, Iss, Pp 434-446 (2021)
Prostate cancers are considered “cold” tumors characterized by minimal T cell infiltrates, absence of a type I interferon (IFN) signature, and the presence of immunosuppressive cells. This non-inflamed phenotype is likely responsible for the lack
Autor:
Oliver J. Gurney-Champion, Uwe Oelfke, Brian Ng-Cheng-Hin, Jennifer P. Kieselmann, Kee H. Wong, Kevin J. Harrington
Publikováno v:
Physics and Imaging in Radiation Oncology, Vol 15, Iss, Pp 1-7 (2020)
Physics and Imaging in Radiation Oncology, 15, 1-7. Elsevier Ireland Ltd
Physics and Imaging in Radiation Oncology
Physics and Imaging in Radiation Oncology, 15, 1-7. Elsevier Ireland Ltd
Physics and Imaging in Radiation Oncology
Graphical abstract
Highlights • A deep neural network can accurately contour metastatic lymph nodes on diffusion-weighted-images. • The discrepancy in apparent diffusion coefficient between automated and expert contours was insignificant.
Highlights • A deep neural network can accurately contour metastatic lymph nodes on diffusion-weighted-images. • The discrepancy in apparent diffusion coefficient between automated and expert contours was insignificant.
Autor:
Bas W. Raaymakers, Marcel Verheij, Bruce D. Minsky, Jan J W Lagendijk, Arjun Sahgal, Parag J. Parikh, William A. Hall, Kevin J. Harrington, Ananya Choudhury, Robert J H A Tersteeg, Clifton D. Fuller, Uulke A. van der Heide, Eric S. Paulson, Michael F. Bassetti, Laura A. Dawson, Percy Lee, David A. Jaffray, Beth Erickson, Clifford G. Robinson, X. Allen Li, Christopher J. Schultz
Publikováno v:
Eur J Cancer
European Journal of Cancer, 122, pp. 42-52
European Journal of Cancer, 122, 42-52
European Journal of Cancer, 122, 42. Elsevier Limited
Hall, W A, Paulson, E S, Heide, U A V D, Fuller, C D, Raaymakers, B W, Lagendijk, J J W, Li, X A, Jaffray, D A, Dawson, L A, Erickson, B, Verheij, M, Harrington, K J, Sahgal, A, Lee, P, Parikh, P J, Bassetti, M F, Robinson, C G, Choudhury, A, Tersteeg, J H A & Schultz, C J 2019, ' The Transformation Of Radiation Oncology Using Real-Time Magnetic Resonance Guidance : A Review ', European Journal of Cancer . https://doi.org/10.1016/j.ejca.2019.07.021
European Journal of Cancer, 122, pp. 42-52
European Journal of Cancer, 122, 42-52
European Journal of Cancer, 122, 42. Elsevier Limited
Hall, W A, Paulson, E S, Heide, U A V D, Fuller, C D, Raaymakers, B W, Lagendijk, J J W, Li, X A, Jaffray, D A, Dawson, L A, Erickson, B, Verheij, M, Harrington, K J, Sahgal, A, Lee, P, Parikh, P J, Bassetti, M F, Robinson, C G, Choudhury, A, Tersteeg, J H A & Schultz, C J 2019, ' The Transformation Of Radiation Oncology Using Real-Time Magnetic Resonance Guidance : A Review ', European Journal of Cancer . https://doi.org/10.1016/j.ejca.2019.07.021
Radiation therapy (RT) is an essential component of effective cancer care and is used across nearly all cancer types. The delivery of RT is becoming more precise through rapid advances in both computing and imaging. The direct integration of magnetic
Autor:
David I. Rosenthal, Stephen Y. Lai, Chris H.J. Terhaard, Clifton D. Fuller, Kristy K. Brock, Mussadiq Awan, Cornelis A. T. van den Berg, John Garcia, Ying Yuan, Adam S. Garden, Abdallah S.R. Mohamed, Uulke A. van der Heide, Kelli McSpadden, Sweet Ping Ng, Peter A Balter, Yao Ding, Abrahim Al-Mamgani, Jihong Wang, Christopher M. Nutting, Jack Phan, Pierre Blanchard, Kevin J. Harrington, Linda G W Kerkmeijer, Marielle E.P. Philippens, Andrew J. McPartlin, Jared R. Robbins, Molly M. McCulloch, S. Blinde, Houda Bahig, Irene Karam, Uwe Oelfke, Jan-Jakob Sonke, Katherine Newbold, X. Allen Li, Cornelis P.J. Raaijmakers, Steven J. Frank, Guillaume Cazoulat, Gary Brandon Gunn, Michalis Aristophanous, Shreerang Bhide, Patricia Doornaert, Katherine A. Hutcheson
Publikováno v:
Clinical and Translational Radiation Oncology, Vol 13, Iss, Pp 19-23 (2018)
Clinical and Translational Radiation Oncology
Clinical and Translational Radiation Oncology, 13, 19-23. Elsevier Ireland Ltd
Clinical and Translational Radiation Oncology
Clinical and Translational Radiation Oncology, 13, 19-23. Elsevier Ireland Ltd
Highlights • Treatment de-escalation in HPV+ oropharynx cancer is an active area of research. • A Bayesian phase II trial of MR-guided radiotherapy dose adaptation is proposed. • High dose volume will be adapted on weekly MRI based on tumor res
Autor:
Mansour T. A. Sharabiani, Paul Carter, S.A. Bhide, Kevin J. Harrington, R. Shaikh, Isaac Garcia-Murillas, D.M. Allin, Katie L. Newbold, Khin Thway, D. Kim, D. Gonzales-de-Castro, Ben O'Leary, Mike Hubank
Publikováno v:
European Journal of Cancer. 103:165-175
Background Conventional biomarkers in thyroid cancer are not disease specific and fluctuate in advanced disease, making interpretation difficult. Circulating tumour DNA (ctDNA) has been shown to be a useful biomarker in other solid tumours. This is a
Autor:
Martin Forster, Kabir Mohammed, Glen Clack, Clare Peckitt, Simon Smith, Kevin J. Harrington, James Spicer, Udai Banerji, Magnus T. Dillon, J. Guevara, Mark P Saunders, Z. Boylan, D. Smith
Publikováno v:
Clinical and Translational Radiation Oncology
Clinical and Translational Radiation Oncology, Vol 12, Iss, Pp 16-20 (2018)
Clinical and Translational Radiation Oncology, Vol 12, Iss, Pp 16-20 (2018)
Highlights • Summary of a protocol for a phase I study combining the ATR inhibitor and palliative radiotherapy. • Study design is discussed. • Study aims and objectives, brief eligibility criteria, DLT criteria and dose escalation is discussed.