Zobrazeno 1 - 10
of 32
pro vyhledávání: '"Kevin Chipman"'
Autor:
Lynda Webster, Colin F. Moffat, Michael J. Leaver, Stephen G. George, J. Kevin Chipman, Tim D. Williams, Craig D. Robinson, Amer Diab, Huifeng Wu, Mark R. Viant, Ian M. Davies
Publikováno v:
Chemosphere. 108:152-158
Molecular responses to acute toxicant exposure can be effective biomarkers, however responses to chronic exposure are less well characterised. The aim of this study was to determine chronic molecular responses to environmental mixtures in a controlle
Autor:
Matthew J. Winter, Rhiannon David, Huw S. Jones, Grace H. Panter, J. Kevin Chipman, Thomas H. Hutchinson
Publikováno v:
Chemosphere
Highlights ► Daphnia magna have a detectable activity towards ethoxyresorufin. ► This activity is unaffected by 24 h exposure to dimethylsulfoxide or methanol. ► EROD activity in zebrafish is inhibited by 24 h exposure to both DMSO and methanol
Autor:
Leda Mirbahai, Angela Mally, Kevin Hickling, Carolin Hamberger, Tim D. Williams, Tao Chen, J. Kevin Chipman
Publikováno v:
Toxicology. 292:63-70
Furan, a widely used industrial compound, has been found in a number of heated food items. Furan is carcinogenic to rats and mice, but the mechanism behind its carcinogenic effect is still not well understood. In this study, we tested the hypothesis
Autor:
Mohammed Baalousha, Mark R. Viant, Isabella Römer, Thomas A. White, Jamie R. Lead, Kevin Chipman
Publikováno v:
Journal of Chromatography A. 1218:4226-4233
Silver nanoparticles (AgNPs) are currently being very widely used in industry, mainly because of their anti-bacterial properties, with applications in many areas. Once released into the environment, the mobility, bioavailability, and toxicity of AgNP
Autor:
J. Kevin Chipman, Carmen Pueyo, Inmaculada Osuna-Jiménez, Timothy Williams, María-José Prieto-Álamo, Nieves Abril
Publikováno v:
Fish & Shellfish Immunology. 26:699-706
The sole, Solea senegalensis, is a common flatfish of Atlantic and Mediterranean waters with a high potential for aquaculture. However, its cultivation is hampered by high sensitivity to different stresses and several infectious diseases. Improving p
Publikováno v:
Toxicology. 256:143-151
We evaluated the effects of two putative non-genotoxic hepatic carcinogens, hexabromocyclododecane (HBCD) and 17-beta oestradiol (E(2)) on global and CpG promoter DNA methylation in both primary human hepatocytes and hepatocellular carcinoma (HepG2)
Autor:
Victoria Sabine, Amer Diab, Fernando Ortega, Stephen G. George, Tim D. Williams, J. Kevin Chipman, Rita E. Godfrey, Francesco Falciani
Publikováno v:
Aquatic Toxicology. 90:83-91
The temporal transcriptomic responses in liver of Platichthys flesus to model environmental pollutants were studied over a 16-day time span after intraperitoneal injection with cadmium chloride (50 μg/kg in saline), 3-methylcholanthrene (25 mg/kg in
Publikováno v:
Environmental Pollution. 151:663-668
Mussels were collected from the urban/industrialized site of New Brighton, Merseyside and the relatively non-industrial site of Llandudno, North Wales. All mussels were identified as Mytilus edulis by PCR amplification of Mefp1 . DNA single strand br
Publikováno v:
Marine Environmental Research. 58:649-653
CYP1A-immunopositive protein can be elevated in response to planar PAHs and PCBs in Mytilus sp. digestive gland whilst CYP3A-immunopositive protein has been associated with testosterone 6β-hydroxylation in fish. Levels of CYP1A- and CYP3A-immunoposi
Publikováno v:
Marine Environmental Research. 58:101-105
The induction of hepatic cytochrome P450 1A (CYP 1A) is an important step in the response to contaminants such as polycyclic aromatic hydrocarbons (PAHs), and has been used as a biomarker of exposure in fish. Several consensus response elements have