Zobrazeno 1 - 10
of 16
pro vyhledávání: '"Karel Souček"'
Autor:
Vladimír Velebný, Matěj Šimek, Tereza Foglová, Lucia Binó, Karel Souček, Daniela Šmejkalová, Martina Hermannová
Publikováno v:
Carbohydrate Polymers. 209:181-189
A better understanding of in vivo behavior of nanocarriers is necessary for further improvement in their development. Here we present a novel approach, where both the matrix and the drug can be analyzed by LC MS/MS after one sample handling. The deve
Autor:
Ján Remšík, Aleš Hampl, Lucia Binó, Eva Slabáková, Karel Souček, Zuzana Kahounová, Daniela Kurfűrstová, Volodymyr Porokh, Radek Fedr, Vladimír Študent, Jan Bouchal, Radek Vrtěl, Lucie Jurečková
Publikováno v:
Stem Cell Research, Vol 33, Iss, Pp 255-259 (2018)
A human induced pluripotent stem cell line was generated from cancer-associated fibroblasts of a 68-years old patient with diagnosed prostate adenocarcinoma (PCa). The fibroblast cell line was reprogrammed with Epi5™ Episomal iPSC Reprogramming Kit
Autor:
Václav Němec, Stefan Knapp, Apirat Chaikuad, Benedict-Tilman Berger, Stanislav Drápela, Kamil Paruch, Karel Souček, Lukáš Maier
Publikováno v:
European Journal of Medicinal Chemistry. 215:113299
The furo [3,2-b]pyridine motif represents a relatively underexplored central pharmacophore in the area of kinase inhibitors. Herein, we report flexible synthesis of 3,5-disubstituted furo [3,2-b]pyridines that relies on chemoselective couplings of ne
Autor:
Zdeněk Andrysík, Radek Fedr, Josef Mašek, Miroslav Machala, Jan Topinka, Eva Hrubá, Simona Strapáčová, Lucie Svržková, Ondřej Vacek, Martina Hýžďalová, Jiří Kléma, Karel Souček, Jiřina Procházková, Jan Vondráček, Helena Libalova
Publikováno v:
Chemosphere. 263:128126
Deciphering the role of the aryl hydrocarbon receptor (AhR) in lung cancer cells may help us to better understand the role of toxic AhR ligands in lung carcinogenesis, including cancer progression. We employed human lung carcinoma A549 cells to inves
Autor:
R. Fedr, Stanislav Drápela, X.M. Muresan, Ján Remšík, E. Slabakova, Zoran Culig, Karel Souček
Publikováno v:
European Urology Supplements. 18:e3124
Autor:
Vítězslav Bryja, Miroslav Machala, Jan Topinka, Eva Hrubá, Karel Souček, Jan Vondráček, Helena Libalova
Publikováno v:
Toxicology Letters. 206:178-188
Carcinogenic polycyclic aromatic hydrocarbons (PAHs) are known as efficient mutagens and ligands of the aryl hydrocarbon receptor (AhR), which has been suggested to play an important role in prostate carcinogenesis. In order to evaluate the complex r
Publikováno v:
Cellular Signalling. 22:1734-1744
Chronic inflammation plays an important role in the initiation and progression of various human diseases including benign prostatic hyperplasia or prostate cancer. Here we show that the proinflammatory cytokine interleukin-6 (IL-6) has prosurvival ef
Publikováno v:
Differentiation. 78:213-222
Survival and capability of cancer cells to form metastases fundamentally depend on interactions with their microenvironment. Secondary tumors originating from prostate carcinomas affect remodeling of bone tissue and can induce both osteolytic and ost
Autor:
Aleš Hampl, Zuzana Pernicová, Pavel Krčmář, Alois Kozubík, Andrea Staršíchová, Eva Lincová, Karel Souček, Miroslav Machala
Publikováno v:
Biochemical Pharmacology. 78:561-572
Antitumorigenic effects of non-steroidal anti-inflammatory drugs (NSAIDs) are well established in several types of cancer disease. However, the mechanisms driving these processes are not understood in all details. In our study, we observed significan
Autor:
Ales Kroutil, Petr Sova, Jirina Hofmanova, Alois Kozubík, Peter Fedoročko, Lenka Svihálková-Sindlerová, Olga Blanárová, Karel Souček, Viktor Horváth
Publikováno v:
Gynecologic Oncology. 102:32-40
Objectives. The resistance of tumor cells to cisplatin remains a major cause of treatment failure in cancer patients. In this study, the ability of Pt(IV) complex with adamantylamine-LA-12 and its reduced counterpart with lower oxidation state Pt(II)