Zobrazeno 1 - 10
of 32
pro vyhledávání: '"Jeffrey M. Peters"'
Publikováno v:
Biochemical and Biophysical Research Communications. 504:582-589
The tumor microenvironment can be hypoxic, acidic, and deficient in nutrients. This can cause the metabolism of tumor cells as well as the neighboring stromal cells to be remodelled to facilitate tumor survival, proliferation, and metastasis. Abnorma
Autor:
Bokai Zhu, Brooke E. Shannon, Christina Lee, Ashley L. Wagner, Jeffrey M. Peters, Ellen M. Kehres, Frank J. Gonzalez, Michael G. Borland, Prajakta P. Albrecht
Publikováno v:
Toxicology. :25-32
To examine the functional role of peroxisome proliferator-activated receptor-β/δ (PPARβ/δ) and PPARγ in skin cancer, stable cell lines were created in the A431 human squamous cell carcinoma cell line. Expression of PPAR target genes was greatly
Autor:
Gayathri Balandaram, Gary H. Perdew, Albert J. Fornace, Takayuki Koga, Frank J. Gonzalez, Iain A. Murray, Maryam Goudarzi, Jeffrey M. Peters, Pei-Li Yao
Publikováno v:
Journal of Biological Chemistry. 291:25255-25263
Alcoholic liver disease is a pathological condition caused by overconsumption of alcohol. Because of the high morbidity and mortality associated with this disease, there remains a need to elucidate the molecular mechanisms underlying its etiology and
Publikováno v:
Journal of Biological Chemistry. 290:23416-23431
Ppard(-/-) mice exhibit smaller litter size compared with Ppard(+/+) mice. To determine whether peroxisome proliferator-activated receptor-D (PPARD) could possibly influence this phenotype, the role of PPARD in testicular biology was examined. Atroph
Autor:
Young Tae Kim, Hyun Jai Cho, Seung Bum Ryoo, Eun Byeol Hong, Ji Min Yang, Sang Eun Lee, Jin Hur, Hyo-Soo Kim, Jae Il Choi, Young Chan Kim, Ju Young Kim, Jonghanne Park, Jeffrey M. Peters
Publikováno v:
Cell Reports, Vol 10, Iss 9, Pp 1614-1625 (2015)
CELL REPORTS(10): 9
CELL REPORTS(10): 9
We investigate crosstalk between cancer cells and stromal myeloid cells. We find that Lewis lung carcinoma cells significantly induce PPAR beta/delta activity in myeloid cells in vitro and in vivo. Myeloid cell-specific knockout of PPAR beta/delta re
Autor:
Jeffrey M. Peters, Combiz Khozoie, Takayuki Koga, Maryam Goudarzi, Boo-Hyon Kang, Albert J. Fornace, Tytus D. Mak
Publikováno v:
Toxicology. 311:87-98
Because of the significant morbidity and lethality caused by alcoholic liver disease (ALD), there remains a need to elucidate the regulatory mechanisms that can be targeted to prevent and treat ALD. Towards this goal, minimally invasive biomarker dis
Autor:
Massimo Curini, Jennifer E. Foreman, Salvatore Genovese, Francesco Epifano, Jeffrey M. Peters, Frank J. Gonzalez, Michael G. Borland
Publikováno v:
Life Sciences. 86:493-498
Aims Previous studies showed that natural prenyloxyphenylpropanoid derivatives have potent biological properties in vivo . Given the structural similarities between these compounds and known peroxisome proliferator-activated receptor (PPAR) agonists,
Publikováno v:
Prostaglandins & Other Lipid Mediators. 88:97-100
Cyclooxygenase-2 (COX-2), overexpressed in inflammatory conditions and cancer, regulates angiogenesis and tumorigenesis via the production of biologically active prostanoids. Previously, we showed that COX-2 over-expression in the mammary gland of tr
Autor:
Shantu Amin, Karam El-Bayoumy, Michael G. Borland, Frank J. Gonzalez, Arun Sharma, Pengfei He, Bokai Zhu, Jeffrey M. Peters
Publikováno v:
Toxicology. 254:112-117
There is compelling evidence that peroxisome proliferator-activated receptor-β/δ (PPARβ/δ) mediates terminal differentiation and is associated with inhibition of cell growth. However, it was recently suggested that growth of two human lung cancer
Autor:
Jeffrey M. Peters, Elizabeth E. Girroir, Bokai Zhu, Holly E. Hollingshead, Gary H. Perdew, Pengfei He
Publikováno v:
Biochemical and Biophysical Research Communications. 371:456-461
The expression patterns of PPARβ/δ have been described, but the majority of these data are based on mRNA data. To date, there are no reports that have quantitatively examined the expression of PPARβ/δ protein in mouse tissues. In the present stud