Zobrazeno 1 - 10
of 25
pro vyhledávání: '"Huaxin Sheng"'
Autor:
Weina Duan, Qian Sun, Xiaojing Wu, Zhongyuan Xia, David S. Warner, Luis Ulloa, Wei Yang, Huaxin Sheng
Publikováno v:
Neuromodulation: Technology at the Neural Interface. 25:414-423
Cerebral ischemia and reperfusion (I/R) induces oxidative stress and activates autophagy, leading to brain injury and neurologic deficits. Cervical vagus nerve stimulation (VNS) increases cerebral blood flow (CBF). In this study, we investigate the e
Autor:
Huaxin Sheng, Ying Li, Wulf Paschen, Xiaozhi Liu, Shuai Liu, David S. Warner, Lin Zhang, Wei Yang, Julia Q. Zhao
Publikováno v:
Neuroscience. 343:190-212
Small ubiquitin-like modifier (SUMO) conjugation (SUMOylation) plays key roles in neurologic function in health and disease. Neuronal SUMOylation is essential for emotionality and cognition, and this pathway is dramatically activated in post-ischemic
Autor:
Li Du, Ines Batinic-Haberle, Angeles Alvarez Secord, Artak Tovmasyan, Zhiqing Huang, Shara Reihani, Weina Duan, Zhipeng Cao, Ivan Spasojevic, Huaxin Sheng
Publikováno v:
Free Radical Biology and Medicine. 159:S51
Autor:
Francesca Galeffi, Ya-chao Wang, Xuan Li, Wei Wang, Wei Yang, Huaxin Sheng, Ulrike Hoffmann, Dennis A. Turner, Liping Lu
Publikováno v:
Exp Neurol
Background and purpose Ischemic stroke significantly perturbs neuronal homeostasis leading to a cascade of pathologic events causing brain damage. In this study, we assessed acute stroke outcome after chemogenetic inhibition of forebrain excitatory n
Autor:
Miaomiao Lu, Jun Hong, Victoria Jones, Somnath Mukhopadhyay, David S. Warner, Vijaya B. Nandiwada, Huaxin Sheng
Publikováno v:
Neuroscience Letters. 597:19-24
Increased matrix metalloproteinase (MMP) activity contributes to glial scar formation that inhibits the repair path after spinal cord injury (SCI). We examined whether treatment with N-(2-chloroethyl)-5Z,8Z,11Z,14Z-eicosatetraena
Autor:
Ines Batinic-Haberle, Bridget F. Koontz, Qingfu Zhang, Artak Tovmasyan, Ivan Spasojevic, Jiaoti Huang, Huaxin Sheng
Publikováno v:
Free Radical Biology and Medicine. 112:35-36
Prostate cancer is the most common cancer in American men, with approximately 30-50% of men developing loss of erectile function after definitive radiotherapy (RT). Currently, no treatment is available that preserves erectile function. Therefore ther
Autor:
David S. Warner, Huaxin Sheng, Robert B. Yates, Mark Stafford-Smith, Daniel T. Kleven, Noelle A. DeSimone, Hiroaki Sakai
Publikováno v:
Journal of Cardiothoracic and Vascular Anesthesia. 27:71-78
Acute kidney injury (AKI) and ischemic stroke may occur in the same cardiac surgical patient. It is not known if an interaction exists between these organ injuries. Isolated renal ischemia/reperfusion is associated with dysfunction in remote, otherwi
Autor:
Joseph P. Mathew, G. Burkhard Mackensen, Jae Kwang Shim, Huaxin Sheng, Ma Qing, Hilary P. Grocott
Publikováno v:
The Journal of Thoracic and Cardiovascular Surgery. 142(2):424-429
Objective Higher mean arterial pressure during cardiopulmonary bypass may improve cerebral outcome associated with cerebral air embolism by increasing emboli clearance and collateral flow to salvage the ischemic penumbra. However, this may come at th
Autor:
Frederick W. Lombard, Gavin W. Britz, Huaxin Sheng, David S. Warner, Wei Yang, Zhengfeng Wang
Publikováno v:
Journal of Neuroscience Methods. 189:246-251
Use of genetically manipulated mice facilitates understanding pathological mechanisms in many diseases and contributes to therapy development. However, there is no practical and clinically relevant mouse model available for spinal cord ischemia. This
Publikováno v:
Journal of the American College of Cardiology. 70:C4
Small ubiquitin-like modifier (SUMO1-3) conjugation (SUMOylation), a post-translational modification, modulates activity of a large number of nuclear proteins, including transcriptional factors and chromatin-associated proteins, and plays a crucial r