Zobrazeno 1 - 10
of 44
pro vyhledávání: '"Gail V.W. Johnson"'
Publikováno v:
Neurobiology of Aging. 63:128-139
During aging, decreased efficiency of nuclear factor (erythroid-derived 2)-like 2 (Nrf2) activation and autophagic processes in the brain may be a contributing factor in the pathogenesis of neurodegenerative diseases such as Alzheimer's disease. Ther
Publikováno v:
Molecular and Cellular Neuroscience. 86:72-80
The protein transglutaminase 2 (TG2) has been implicated as a modulator of neuronal viability. TG2's role in mediating cell survival processes has been suggested to involve its ability to alter transcriptional events. The goal of this study was to ex
Publikováno v:
Biochemical and Biophysical Research Communications. 482:942-947
Astrocytes play numerous complex roles that support and facilitate the function of neurons. Further, when there is an injury to the central nervous system (CNS) they can both facilitate or ameliorate functional recovery depending on the location and
Publikováno v:
Brain Research. 1634:119-131
Excitotoxicity was originally postulated to be a late stage side effect of Alzheimer׳s disease (AD)-related neurodegeneration, however more recent studies indicate that it may occur early in AD and contribute to the neurodegenerative process. Tau an
Publikováno v:
Neurobiology of Aging. 36:241-248
Tau is a microtubule associated protein that is found primarily in neurons, and in pathologic conditions, such as Alzheimer's disease (AD) it accumulates and contributes to the disease process. Because tau plays a fundamental role in the pathogenesis
Publikováno v:
Biochimica et Biophysica Acta (BBA) - Molecular Cell Research. 1823:406-419
Transglutaminase 2 (TG2) is the most widely distributed member of the transglutaminase family with almost all cell types in the body expressing TG2 to varying extents. In addition to being widely expressed, TG2 is an extremely versatile protein exhib
Publikováno v:
Neurobiology of Disease, Vol 39, Iss 3, Pp 334-343 (2010)
Transglutaminase 2 (TG2) is a multifunctional protein that modulates cell survival and death pathways. It is upregulated in numerous ischemic models, and protects primary neurons from oxygen and glucose deprivation. TG2 binds to the hypoxia inducible
Publikováno v:
Journal of Biological Chemistry. 284:18754-18766
In Alzheimer disease (AD) mitochondrial abnormalities occur early in the pathogenic process and likely play a significant role in disease progression. Tau is a microtubule-associated protein that is abnormally processed in AD, and a connection betwee
Publikováno v:
Brain Research. 1234:206-212
It has been previously reported that an Asp421 cleaved form of tau is toxic when expressed in cells. The purpose of this study was to understand if, and in what manner, the presence of Asp421 cleaved tau in neurons, which is generated by caspase clea
Autor:
Rodrigo A. Quintanilla, Karen Fuenzalida, Gail V.W. Johnson, Miguel Bronfman, Youngnam N. Jin
Publikováno v:
Journal of Biological Chemistry. 283:25628-25637
Peroxisome proliferator-activated receptor-γ (PPARγ) is a member of the PPAR family of transcription factors. Synthetic PPARγ agonists are used as oral anti-hyperglycemic drugs for the treatment of non-insulin-dependent diabetes. However, emerging