Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Daniel S. Marsman"'
Autor:
Lara O’Keeffe, Nigel J. Walker, Catherine Mahony, Daniel S. Marsman, Nicholas H. Oberlies, Suzanne Fitzpatrick, James C. Griffiths, A. Wallace Hayes, James Edwards, Corrado L. Galli, Amy L. Roe
Publikováno v:
Toxicology Letters. 314:10-17
Botanical safety science continues to evolve as new tools for risk assessment become available alongside continual desire by consumers for "natural" botanical ingredients in consumer products. Focusing on botanical food/dietary supplements a recent i
Autor:
Stefan Gafner, Joseph T. Dever, James C. Griffiths, Cara Welch, Cynthia V. Rider, Michelle R. Embry, Constance A. Mitchell, Daniel S. Marsman
Publikováno v:
Regulatory Toxicology and Pharmacology. 128:105090
Botanical dietary supplement use is widespread and growing, therefore, ensuring the safety of botanical products is a public health priority. This commentary describes the mission and objectives of the Botanical Safety Consortium (BSC) - a public-pri
Publikováno v:
Food and Chemical Toxicology. 107:418-429
Botanicals used in dietary supplements industry can have toxicology concerns related to endpoint gaps that cannot be fully resolved by a history of use, or existence of conflicting safety data. However, traditional toxicological studies on botanicals
Autor:
Brian G. Lake, John G. DeLuca, Walter Wahli, Daniel S. Marsman, Timothy A. Pastoor, Penelope A. Fenner-Crisp, Russell C. Cattley, Jonathan Tugwood, Bernard A. Schwetz, Cliff Elcombe, Denise Robinson, James A. Popp
Publikováno v:
Regulatory Toxicology and Pharmacology. 27:47-60
The purpose of the workshop "Do Peroxisome Proliferating Compounds Pose a Hepatocarcinogenic Hazard to Humans?" was to provide a review of the current state of the science on the relationship between peroxisome proliferation and hepatocarcinogenesis.
Autor:
Blair U. Bradford, Ronald G. Thurman, Heidi K. Bojes, Barbara J. Keller, Daniel S. Marsman, James A. Popp, Russell C. Cattley
Publikováno v:
Toxicology and Applied Pharmacology. 119:52-58
Wy-14,643 is a potent nongenotoxic hepatic carcinogen and peroxisome proliferator in rodents; however, the mechanism by which it causes tumors remains unknown. In previous work it was demonstrated that Wy-14,643 caused a dose-dependent uncoupling of
Publikováno v:
Biochimica et Biophysica Acta (BBA) - Protein Structure and Molecular Enzymology. 1102:237-244
A number of plasticizers and lipid-lowering drugs induce peroxisomes and cause hepatocellular carcinoma in rodents by mechanisms which remain unknown. In this study, seven structurally dissimilar peroxisome proliferating agents were shown to uncouple
Publikováno v:
Fundamental and Applied Toxicology. 18:149-154
The dose and time dependency of peroxisome proliferation and hepatocyte replication was evaluated in the liver of rats fed the peroxisome proliferator and hepatocarcinogen, Wy-14,643. Male F344 rats were fed NIH07 diet blended with Wy-14,643 at 0, 5,
Publikováno v:
Toxicology. 56:1-7
The ability of the peroxisome proliferator WY-14,643 to act as an initiator of hepatocarcinogenesis was examined using a modified growth-selection protocol in rats. Feeding rats 0.1% WY-14,643 in the diet for 3 weeks, coupled with partial hepatectomy