Zobrazeno 1 - 10
of 23
pro vyhledávání: '"Christopher L.-H. Huang"'
Autor:
Christopher A. Beaudoin, Emmanouela Petsolari, Samir W. Hamaia, Sharif Hala, Fadwa S. Alofi, Arun P. Pandurangan, Tom L. Blundell, Sundeep Chaitanya Vedithi, Christopher L.-H. Huang, Antony P. Jackson
Publikováno v:
Biochemical and Biophysical Research Communications. 666:61-67
The RGD motif on the SARS-CoV-2 spike protein has been suggested to interact with RGD-binding integrins αVβ3 and α5β1 to enhance viral cell entry and alter downstream signaling cascades. The D405N mutation on the Omicron subvariant spike proteins
Autor:
Ying H. Huang, Jane V. Lyle, Anisa Shahira Ab Razak, Manasi Nandi, Celia M. Marr, Christopher L.-H. Huang, Philip J. Aston, Kamalan Jeevaratnam
Publikováno v:
Cardiovascular Digital Health Journal. 3:96-106
Atrial fibrillation (AF) is a common cardiac arrhythmia in both human and equine populations. It is associated with adverse outcomes in humans and decreased athletic performance in both populations. Paroxysmal atrial fibrillation (PAF) presents with
Publikováno v:
Journal of Molecular and Cellular Cardiology. 139:190-200
The SCN5A gene encodes Nav1.5, which, as the cardiac voltage-gated Na+ channel's pore-forming α subunit, is crucial for the initiation and propagation of atrial and ventricular action potentials. The arrhythmogenic propensity of inherited SCN5A muta
Publikováno v:
International Journal of Cardiology. Heart & Vasculature
International Journal of Cardiology: Heart & Vasculature, Vol 26, Iss, Pp-(2020)
International Journal of Cardiology: Heart & Vasculature, Vol 26, Iss, Pp-(2020)
Sigma-1 receptors are ligand-regulated chaperone proteins, involved in several cellular mechanisms. The aim of this systematic review was to examine the effects that the sigma-1 receptor has on the cardiovascular system. The interaction targets and p
Publikováno v:
Stem Cell Research, Vol 39, Iss, Pp-(2019)
Induced pluripotent stem cells (iPSCs) were generated from peripheral blood mononuclear cells (PBMCs) isolated from the peripheral blood of a 4 month-old boy with catecholaminergic polymorphic ventricular tachycardia carrying the double heterozygous
Publikováno v:
Cardiac Electrophysiology Clinics. 2:509-519
Progressive cardiac conduction disease (PCCD), a source of considerable morbidity, comprises a heterogeneous group of conditions resulting from genetic predisposition, environmental modifiers, and other physiologic determinants, including aging. The
Publikováno v:
Journal of Electrocardiology
ObjectivesWe investigate the extent to which the electrocardiographic (ECG) properties of intact Scn5a+/− mice reproduce the corresponding clinical Brugada syndrome phenotype and use this model to investigate the role of conduction and repolarizati
Publikováno v:
Journal of Molecular and Cellular Cardiology. 47:622-633
Cardiac myocytes are continuously exposed to extracellular nucleotides secreted by the myocytes themselves, nerve terminals, or platelets and other blood cells during coronary perfusion, and the concentrations of such extracellular nucleotides are kn
Publikováno v:
Progress in Biophysics and Molecular Biology. 98:171-178
Voltage-gated Na+ channels are transmembrane proteins that produce the fast inward Na+ current responsible for the depolarization phase of the cardiac action potential. They play fundamental roles in the initiation, propagation, and maintenance of no
Autor:
Stephen W. Booth, Fergus Simpson, Christopher L.-H. Huang, Sandeep S. Hothi, Yanmin Zhang, Andrew A. Grace, Matthew J. Killeen, Ian N. Sabir
Publikováno v:
Progress in Biophysics and Molecular Biology. 98:267-280
The gain-of-function Scn5a+/DeltaKPQ mutation in the cardiac Na(+) channel causes human long QT type 3 syndrome (LQT3) associated with ventricular arrhythmogenesis. The K(ATP) channel-opener nicorandil (20muM) significantly reduced arrhythmic inciden