Zobrazeno 1 - 10
of 16
pro vyhledávání: '"Brian T. Layden"'
Autor:
Brian T. Layden, Samuel M Lee, Carolina M. Pusec, Andre Sarmento-Cabral, Grace Guzman, Jose Muratalla, Jose Cordoba-Chacon, Alberto Diaz-Ruiz, Gregory H Norris, Adam De Jesus
Publikováno v:
Cellular and Molecular Gastroenterology and Hepatology
Cellular and Molecular Gastroenterology and Hepatology, Vol 11, Iss 5, Pp 1291-1311 (2021)
Cellular and Molecular Gastroenterology and Hepatology, Vol 11, Iss 5, Pp 1291-1311 (2021)
Background & Aims Nonalcoholic steatohepatitis (NASH) is commonly observed in patients with type 2 diabetes, and thiazolidinediones (TZD) are considered a potential therapy for NASH. Although TZD increase insulin sensitivity and partially reduce stea
Publikováno v:
Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease. 1865:678-687
Hexokinase domain containing 1, a recently discovered putative fifth hexokinase, is hypothesized to play key roles in glucose metabolism. Specifically, during pregnancy in a recent genome wide association study (GWAS), a strong correlation between HK
Autor:
Hossein Ardehali, Justin Geier, Trenton Nicioli, Joshua S. Stoolman, Krishna V. Suresh, Samuel E. Weinberg, Lauren Goodman, Adam De Jesus, Kai Xu, Hsiang-Chun Chang, Paulina J Stanczyk, Chunlei Chen, Navdeep S. Chandel, Carolina M. Pusec, Arianne E. Rodriguez, Brian T. Layden, Issam Ben-Sahra, Jason S. Shapiro, Yihan Chen, Kriti P. Shah, Farnaz Keyhani-Nejad
Publikováno v:
Molecular Cell. 82:1261-1277.e9
The product of hexokinase (HK) enzymes, glucose-6-phosphate, can be metabolized through glycolysis or directed to alternative pathways, such as the pentose phosphate pathway (PPP) to generate anabolic intermediates. However, it is not known what dete
Autor:
Weiran Zhang, Nan Wang, Medha Priyadarshini, Jose Cordoba-Chacon, Brian T. Layden, Kenta Kuramoto, Congcong He, Soh Yamamoto, Xiaolei Situ
Publikováno v:
Cell Reports, Vol 23, Iss 11, Pp 3286-3299 (2018)
Summary: Autophagy, a stress-induced lysosomal degradative pathway, has been assumed to exert similar metabolic effects in different organs. Here, we establish a model where autophagy plays different roles in insulin-producing β cells versus insulin
Publikováno v:
Curr Dev Nutr
OBJECTIVES: Short chain fatty acids (SCFAs), which are gut microbial fermentation byproducts with suggested positive health effects, have emerged as a therapeutic modality against metabolic diseases like obesity and type 2 diabetes. Alluringly, in vi
Autor:
Brian R. Boulay, H. Rex Gaskins, Lisa Tussing-Humphreys, Brian T. Layden, Mitali Agarwal, Paul J. Grippo, Ece Mutlu, Kashif Osmani, Karla J. Castellanos, Cemal Yazici
Publikováno v:
Gastroenterology. 160:S-668
Publikováno v:
Trends in Endocrinology & Metabolism. 27:653-664
Nutrient sensing receptors are key metabolic mediators of responses to dietary and endogenously derived nutrients. These receptors are largely G-protein coupled receptors (GPCRs) and many are gaining significant interest as drug targets with a potent
Autor:
Brian T. Layden, Pradeep K. Dudeja, Anoop Kumar, Arivarasu Natarajan Anbazhagan, Shubha Priyamvada, Dulari Jayawardena, Kumar Kotlo
Publikováno v:
Gastroenterology. 158:S-205
Publikováno v:
Gastroenterology. 158:S-1231
Autor:
Eunyoung Chun, Hamid R. Hoveyda, Jonathan N. Glickman, Miles H. Fuller, Sena Bae, Sydney Lavoie, Caitlin A. Brennan, Monia Michaud, Wendy S. Garrett, Jessica K. Lang, Carey Ann Gallini Comeau, Graeme L. Fraser, Brian T. Layden
Publikováno v:
Gastroenterology
BACKGROUND & AIMS: Intestinal microbes and their metabolites affect the development of colorectal cancer (CRC). Short-chain fatty acids are metabolites generated by intestinal microbes from dietary fiber. We investigated the mechanisms by which free