Zobrazeno 1 - 10
of 35
pro vyhledávání: '"Arvind K. Srivastava"'
Glucose uptake stimulatory potential and antidiabetic activity of the Arnebin-1 from Arnabia nobelis
Autor:
Akhilesh K. Tamrakar, Sabbu Sathish Reddy, Arvind K. Srivastava, Tadigoppula Narender, Akansha Mishra, Sukanya Pandeti, Deepti Arha
Publikováno v:
European Journal of Pharmacology. 789:449-457
The enhanced disposal of glucose by the peripheral tissue is an important mechanism to regulate hyperglycemia. Here, we investigated the effect of Arnebin-1 from Arnebia nobilis, on glucose disposal in skeletal muscle cells and explored its in vivo a
Autor:
Rohit Srivastava, Narender Tadigoppula, Arvind K. Srivastava, Jyotsana Pandey, Akhilesh K. Tamrakar, Venkateswarlu Korthikunta, Rohit Singh
Publikováno v:
Phytomedicine. 22:66-70
The nonproteinogenic amino acid, 4-hydroxyisoleucine (1) has been isolated in large quantities from the fenugreek (T. foenum-graecum) seeds. Few novel derivatives (3–11 and 13–18) were prepared from the naturally occurring 4-hydroxyisoleucine (1)
Autor:
Venkateswarlu Korthikunta, Arun Rawat, Akhilesh K. Tamrakar, Sudeep Gautam, Savita Pal, Arvind K. Srivastava, Narender Tadigoppula
Publikováno v:
Fitoterapia. 99:307-317
4-Hydroxyisoleucine (4-HIL) is an unusual amino acid isolated from fenugreek seeds (Trigonella foenum graecum L). Various studies have shown that it acts as an antidiabetic agent yet its mechanism of action is not clear. We therefore investigated the
Autor:
Jitendra Kumar Saxena, Neha Rahuja, Hardik Chandasana, Swati Gupta, Anil N. Gaikwad, Arvind K. Srivastava, Anil K. Saxena, Santosh Kumar, Pawan Kumar Doharey, Rabi Sankar Bhatta, Arun Rawat, Swayam Prakash Srivastava, Sudeep Gautam, Rohit Srivastava, Salil Varshney, Vishal M. Balaramnavar, Yashpal S. Chhonker
Publikováno v:
European Journal of Medicinal Chemistry. 87:578-594
Design and synthesis of protein tyrosine phosphatases-1B (PTP1B) inhibitors are important for the drugs targeted to treat diabetes and obesity. The pharmacophore modeling, docking and scaffold hopping techniques have been applied to discover the nove
Autor:
Arvind Mishra, Kozhiparambil Gopalan Raghu, Arvind K. Srivastava, Kalathookunnel Antony Antu, Sharad Sharma, Mariam Philip Riya
Publikováno v:
Experimental and Toxicologic Pathology. 66:281-291
The beneficial effects of hydroethanol extract of Symplocos cochinchinensis (SCE) has been explored against hyperglycemia associated secondary complications in streptozotocin induced diabetic rat model. The experimental groups consist of normal contr
Autor:
Veena D. Yadav, Vishal M. Balaramnavar, Anil Kumar Saxena, Sudeep Gautam, Shashikant U. Dighe, Sanjay Batra, Arvind K. Srivastava, Rohit Srivastava, Akanksha Mishra
Publikováno v:
Tetrahedron. 70:6841-6850
Reinvestigating the synthesis of allylthiocarbamates from MBH derivatives revealed that they are obtained more efficiently from allylbromides in isopropanol rather than acetates in water. Further unlike reported, the base-mediated intramolecular cycl
Autor:
Swayam Prakash Srivastava, Seturam B. Katti, Daya S. Srivastava, Arvind K. Srivastava, Wahajul Haq, Saman Raza
Publikováno v:
European Journal of Medicinal Chemistry. 63:611-620
A number of thiazolidin-4-one and thiazinan-4-one derivatives were prepared by three component condensation in one pot reaction method. These compounds were evaluated for anti-hyperglycemic activity by in vitro and in vivo assay systems. The compound
Autor:
Padam Kumar, Rakesh Maurya, Arvind K. Srivastava, Mohammad Faheem Khan, Akhilesh K. Tamrakar, Jyotsana Pandey
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 22:4636-4639
A new class of N-substituted piperazine analogues of imbricatolic acid have been designed and synthesized by using the appropriate synthetic routes in excellent yield. All synthesised compounds were screened for their in vitro glucose uptake stimulat
Autor:
Neha Rahuja, Pervez Ahmad, Lalit Prakash Gupta, Akhilesh K. Tamrakar, Swayam Prakash Srivastava, Arvind K. Srivastava, Siddharth Sharma, Atul Kumar
Publikováno v:
Bioorganic & Medicinal Chemistry. 20:2172-2179
A series of propiophenone derivatives (6-23) have been synthesized and evaluated for their in vivo antihyperglycemic activities in sucrose loaded model (SLM), sucrose challenged streptozotocin (STZ-S) induced diabetic rat model and C57BL/KsJ db/db di
Publikováno v:
European Journal of Pharmacology. 670:22-28
Insulin-stimulated glucose uptake in skeletal muscle is decreased in type 2 diabetes due to impaired translocation of insulin-sensitive glucose transporter 4 (GLUT4) from intracellular pool to plasma membrane. Augmenting glucose uptake into this tiss