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pro vyhledávání: '"Christopher L.-H. Huang"'
Publikováno v:
Progress in Biophysics and Molecular Biology. 98:171-178
Voltage-gated Na+ channels are transmembrane proteins that produce the fast inward Na+ current responsible for the depolarization phase of the cardiac action potential. They play fundamental roles in the initiation, propagation, and maintenance of no
Autor:
Stephen W. Booth, Fergus Simpson, Christopher L.-H. Huang, Sandeep S. Hothi, Yanmin Zhang, Andrew A. Grace, Matthew J. Killeen, Ian N. Sabir
Publikováno v:
Progress in Biophysics and Molecular Biology. 98:267-280
The gain-of-function Scn5a+/DeltaKPQ mutation in the cardiac Na(+) channel causes human long QT type 3 syndrome (LQT3) associated with ventricular arrhythmogenesis. The K(ATP) channel-opener nicorandil (20muM) significantly reduced arrhythmic inciden
Publikováno v:
Progress in Biophysics and Molecular Biology. 98:208-218
Ventricular arrhythmias are the key underlying cause of sudden cardiac death, a common cause of mortality and a significant public health burden. Insights into the electrophysiological basis of such phenomena have been obtained using a wide range of