Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Jiri Bartek"'
Autor:
Jiri Bartek, Vyacheslav Akimov, Luis I. Toledo, Claudia Lukas, Maj-Britt Rask, Matthias Altmeyer, Thorkell Gudjonsson, Jiri Lukas, Blagoy Blagoev, Merete Grøfte
Publikováno v:
Altmeyer, M F, Toledo, L, Gudjonsson, T, Grøfte, M, Rask, M-B, Lukas, C, Akimov, V, Blagoev, B, Bartek, J & Lukas, J 2013, ' The Chromatin Scaffold Protein SAFB1 Renders Chromatin Permissive for DNA Damage Signaling ', Molecular Cell, vol. 52, no. 2, pp. 206-220 . https://doi.org/10.1016/j.molcel.2013.08.025
Although the general relevance of chromatin modifications for genotoxic stress signaling, cell-cycle checkpoint activation, and DNA repair is well established, how these modifications reach initial thresholds in order to trigger robust responses rema
Autor:
Jiri Bartek, Martin V. Bennetzen, Jiri Lukas, Dorthe Helena Larsen, Jens S. Andersen, Jakob Bunkenborg
Publikováno v:
Bennetzen, M, Larsen, D H, Bunkenborg, J, Bartek, J, Lukas, J & Andersen, J S 2010, ' Site-specific Phosphorylation Dynamics of the Nuclear Proteome during the DNA Damage Response ', Molecular and Cellular Proteomics, vol. 9, no. 6, pp. 1314-1323 . https://doi.org/10.1074/mcp.M900616-MCP200
Molecular & Cellular Proteomics
Molecular & Cellular Proteomics; Vol 9
Molecular & Cellular Proteomics
Molecular & Cellular Proteomics; Vol 9
To investigate the temporal regulation of the DNA damage response, we applied quantitative mass spectrometry-based proteomics to measure site-specific phosphorylation changes of nuclear proteins after ionizing radiation. We profiled 5204 phosphorylat
Autor:
Jannie Rendtlew Danielsen, Jacob Falck, Jiri Lukas, Raimundo Freire, Kenneth Bødtker Schou, Jiri Bartek, Dorthe Helena Larsen
Publikováno v:
Journal of Biological Chemistry. 284:4140-4147
ATR is a protein kinase that orchestrates the cellular response to replication problems and DNA damage. HCLK2 has previously been reported to stabilize ATR and Chk1. Here we provide evidence that human HCLK2 acts at an early step in the ATR signaling
Autor:
Claudia Lukas, Jiri Lukas, Niels Mailand, Helene Faustrup, Fredrik Melander, Jiri Bartek, Simon Bekker-Jensen
Publikováno v:
Cell. 131(5):887-900
SummaryAccumulation of repair proteins on damaged chromosomes is required to restore genomic integrity. However, the mechanisms of protein retention at the most destructive chromosomal lesions, the DNA double-strand breaks (DSBs), are poorly understo
Publikováno v:
Molecular Cell. 23(3):307-318
We show that Claspin, an adaptor protein required for Chk1 activation, becomes degraded at the onset of mitosis. Claspin degradation was triggered by its interaction with, and ubiquitylation by, the SCFbetaTrCP ubiquitin ligase. This interaction was
Autor:
Kum Kum Khanna, Bin-Bing S. Zhou, Randi G. Syljuåsen, Magtouf Gatei, Kienan I. Savage, Jiri Bartek, Katie Sloper, Claus Storgaard Sørensen, Karen Hobson, Jacob Falck, Jiri Lukas
Publikováno v:
Journal of Biological Chemistry. 278:14806-14811
In mammals, the ATM (ataxia-telangiectasia-mutated) and ATR (ATM and Rad3-related) protein kinases function as critical regulators of the cellular DNA damage response. The checkpoint functions of ATR and ATM are mediated, in part, by a pair of checkp
Autor:
Jacob Falck, Jiri Bartek, Randi G. Syljuåsen, Bin-Bing S. Zhou, Jiri Lukas, Kum Kum Khanna, Lars Rönnstrand, Tine Schroeder, Claus Storgaard Sørensen
Publikováno v:
University of Copenhagen
Chk1 kinase coordinates cell cycle progression and preserves genome integrity. Here, we show that chemical or genetic ablation of human Chk1 triggered supraphysiological accumulation of the S phase-promoting Cdc25A phosphatase, prevented ionizing rad
Autor:
Marco Foiani, Jiri Bartek
Publikováno v:
Cell. 156:392-393
The Golgi apparatus consists of disc-like cisternae, stretching around the nucleus through forces exerted by F-actin and the Golgi membrane protein GOLPH3. Farber-Katz et al. now report that DNA damage triggers Golgi dispersal and inhibits vesicular