Zobrazeno 1 - 10
of 57
pro vyhledávání: '"Preclinical research"'
Autor:
Emile E. Voest, Vivien Veninga
Publikováno v:
Cancer Cell. 39:1190-1201
Summary Tumor organoids have been proposed as a model system for precision medicine. The ability of tumor organoids to retain characteristics of the original tumor makes them unique for cancer research on an individual patient level. Hence, the idea
Publikováno v:
Clinica Chimica Acta. 514:15-23
Kidney transplantation is the most effective treatment for end-stage renal disease, but is limited by the increasing shortage of deceased and living human donor kidneys. Xenotransplantation using pig organs provides the possibility to resolve the iss
Autor:
W.H. Wilson Tang, Pieter Martens
Publikováno v:
JACC: Basic to Translational Science
Corresponding Author
Autor:
Guangbin Shi, Yang Zhao, Shanna Hamilton, Man Liu, Feng Feng, Hong Liu, Radmila Terentyeva, Samuel C. Dudley, Dmitry Terentyev, An Xie, Bum-Rak Choi, Tae Yun Kim
Publikováno v:
JACC: Basic to Translational Science
Visual Abstract
Highlights • Diabetes-induced arrhythmic risk involved activation of innate immunity, elevation of IL-1β, mitochondrial oxidative stress, SR calcium release channel oxidation, and QT prolongation. • Diabetes-induced arrhythm
Highlights • Diabetes-induced arrhythmic risk involved activation of innate immunity, elevation of IL-1β, mitochondrial oxidative stress, SR calcium release channel oxidation, and QT prolongation. • Diabetes-induced arrhythm
Autor:
Hagai Tavori, Matthew A. Muller, Zaverio M. Ruggeri, Paul Mueller, Oleg Varlamov, William Packwood, Dominic W. Chung, Jonathan R. Lindner, Koya Ozawa, Aris Xie, José A. López
Publikováno v:
JACC: Basic to Translational Science
Visual Abstract
Highlights • In murine models of atherosclerosis, excess endothelial-associated vWF results not only in platelet adhesion, but also endothelial expression of leukocyte adhesion molecules, indicating a role of platelets in endot
Highlights • In murine models of atherosclerosis, excess endothelial-associated vWF results not only in platelet adhesion, but also endothelial expression of leukocyte adhesion molecules, indicating a role of platelets in endot
Autor:
Hoda Hatoum, Jason Zakko, Stacey Carey, Joseph D. Drews, Lakshmi Prasad Dasi, Christopher K. Breuer, Aimee K. Armstrong, Olivia Conroy, Megan Heitkemper, John Kelly, Karen Texter, Martin L. Bocks, Kevin M. Blum, Madeleine D. Russell, Shelley Gooden, Ellie Ragsdale, Yen-Lin Wu, Michael S. Sacks, Yadong Wang, James Strainic
Publikováno v:
JACC: Basic to Translational Science
Visual Abstract
Highlights • A fully biodegradable fetal valve was developed using a zinc-aluminum alloy stent and electrospun PCL leaflets. • In vitro evaluation of the valve was performed with accelerated degradation, mechanical, and flow
Highlights • A fully biodegradable fetal valve was developed using a zinc-aluminum alloy stent and electrospun PCL leaflets. • In vitro evaluation of the valve was performed with accelerated degradation, mechanical, and flow
Autor:
Farouc A. Jaffer, Haitham Khraishah, Christian L. Lino Cardenas, Chase W. Kessinger, Adam Mauskapf, Kenneth Rosenfield, Michael R. Jaff, Mark E. Lindsay, Madeleine S. Grau, Mazen Albaghdadi, Guillermo J. Tearney, Peter Libby, Zhonglie Piao, Mohammed M. Chowdhury, Eric A. Osborn, Kanwarpal Singh, Stephan Kellnberger, Elazer R. Edelman
Publikováno v:
JACC: Basic to Translational Science
Elsevier
Elsevier
Visual Abstract
Highlights • Restenosis limits the efficacy of PTA or stent treatment of atherosclerosis in peripheral and coronary artery disease. • Paclitaxel DCBs effectively reduce restenosis; however, recently, their overall safety prof
Highlights • Restenosis limits the efficacy of PTA or stent treatment of atherosclerosis in peripheral and coronary artery disease. • Paclitaxel DCBs effectively reduce restenosis; however, recently, their overall safety prof
Autor:
Emiliano Votta, Carlo Antona, Michal Jaworek, Gianfranco Beniamino Fiore, Guido Gelpi, Omar Antonio Pappalardo, Claudia Romagnoni, Riccardo Vismara, Alberto Redaelli, Matteo Selmi, Nina Ajmone-Marsan, Federico Lucherini
Publikováno v:
Structural Heart. 4:36-45
Background: Functional tricuspid regurgitation (FTR) treatment is challenging and most therapies targeting tricuspid valve (TV) annulus have shown limited durability with high rate of resid...
Autor:
Cuiting Luo, Calvin W. L. Chin, Michael R. Zile, Bo Bai, Weiping Han, Wan Ting Tay, Yanyun Fu, Yu Wang, Jayantha Gunaratne, Philip Lee, Wulin Yang, Hannah Lee Foon, Kangmin Yang, Carolyn S.P. Lam, Aimin Xu
Publikováno v:
JACC: Basic to Translational Science
JACC: Basic to Translational Science, Vol 4, Iss 8, Pp 924-937 (2019)
JACC: Basic to Translational Science, Vol 4, Iss 8, Pp 924-937 (2019)
Visual Abstract
Highlights • The lean diabetic SKO mouse represents a novel and validated murine model of HFpEF. • The SKO HFpEF mouse model recapitulates the cardiac structure and function abnormalities in lean diabetic HFpEF patients in As
Highlights • The lean diabetic SKO mouse represents a novel and validated murine model of HFpEF. • The SKO HFpEF mouse model recapitulates the cardiac structure and function abnormalities in lean diabetic HFpEF patients in As
Publikováno v:
Alcohol
The 2018 Fetal Alcohol Spectrum Disorders Study Group (FASDSG) meeting was entitled “Sex Differences and Vulnerability.” The theme reflected the ongoing NIH initiative to address sex differences in both clinical and preclinical research. The firs