Zobrazeno 1 - 10
of 15
pro vyhledávání: '"Nithya Ramnath"'
Autor:
Alex K. Bryant, Kamya Sankar, Lili Zhao, Garth W. Strohbehn, David Elliott, Drew Moghanaki, Michael J. Kelley, Nithya Ramnath, Michael D. Green
Publikováno v:
European Journal of Cancer. 171:55-63
One year of adjuvant durvalumab following concurrent chemoradiotherapy significantly improves progression-free survival (PFS) and overall survival (OS) for patients with stage III non-small cell lung cancer (NSCLC). However, the optimal length of adj
Autor:
Shruti Jolly, Dafydd G. Thomas, Andrea M. H. Towlerton, James A. Hayman, Khaled A. Hassan, Renato G. Martins, Muneesh Tewari, Christina S. Baik, Lili Zhao, Sylvia Lee, Theodore S. Lawrence, Nithya Ramnath, Timothy L. Frankel, Jason W.D. Hearn, Angel Qin, Bernardo H. L. Goulart, Rafael Santana-Davila, Gregory P. Kalemkerian, Ramesh Rengan, Edus H. Warren, Noah A. Brown, Bryan J. Schneider
Publikováno v:
International Journal of Radiation Oncology*Biology*Physics. 108:170-177
Purpose Preclinical data and subset analyses from immunotherapy clinical trials indicate that prior radiation therapy was associated with better progression-free survival and overall survival when combined with immune checkpoint inhibitors in patient
Autor:
Jason W.D. Hearn, Philip S. Boonstra, Matthew J. Schipper, Theodore S. Lawrence, James A. Hayman, Gregory P. Kalemkerian, Randall K. Ten Haken, Paul Stanton, Nithya Ramnath, S. Hobson, Feng-Ming Spring Kong, Martha M. Matuszak, Shruti Jolly, Peter G. Hawkins
Publikováno v:
Radiotherapy and Oncology. 125:66-72
Background and purpose Current methods to estimate risk of radiation-induced lung toxicity (RILT) rely on dosimetric parameters. We aimed to improve prognostication by incorporating clinical and cytokine data, and to investigate how these factors may
Autor:
Guoan Chen, Hiroe Shiratsuchi, Lili Zhao, Paramita Ray, Zhuwen Wang, Dipankar Ray, Zhuo Zhang, Nithya Ramnath, Jules Lin, David G. Beer
Publikováno v:
Journal of Thoracic Oncology. 12:269-280
Introduction We have previously demonstrated that a subset of lung cancer cells express higher CYP24A1 mRNA, a metabolizing enzyme for 1,25-D3, compared to benign tumors or surrounding normal lung and that high CYP24A1 mRNA expression is associated w
Publikováno v:
Journal of Thoracic Oncology. 9(7):917-926
Introduction: Cigarette smoke associated polycyclic aromatic hydrocarbons can induce key drug-metabolizing enzymes of cytochrome P450 and isoforms of the glucuronyl transferases families. These enzymes metabolize several systemic therapies for lung c
Autor:
Ernest Nadal, Chae Kyung Jeon, Justin A. Colacino, David G. Beer, So Hee Kim, Juan Sandoval, Laura S. Rozek, Paul J. Christensen, Manel Esteller, Nithya Ramnath
Publikováno v:
Journal of Thoracic Oncology. 9(4):473-482
Introduction:1α,25-Dihydroxyvitamin D3 (1,25-D3) is antiproliferative in preclinical models of lung cancer, but in tumor tissues, its efficacy may be limited by CYP24A1 expression. CYP24A1 is the rate limiting catabolic enzyme for 1,25-D3 and is ove
Autor:
Dafydd G. Thomas, Bruce W. Hollis, Guoan Chen, Amanda N. King, So Hee Kim, Nithya Ramnath, Dean E. Brenner, Paul J. Christensen, David G. Beer, Lili Zhao, Robert U. Simpson, Chae Kyung Jeon, Thomas J. Giordano
Publikováno v:
Lung Cancer. 77:265-271
Purpose The anti-proliferative effects of 1α,25-dihydroxyvitamin D 3 (1,25-D 3 , calcitriol, the active form of vitamin D) are mediated by the nuclear vitamin D receptor (VDR). In the present study, we characterized VDR expression in lung adenocarci
Autor:
Khaled A. Hassan, S. Yuan, D. Arenberg, Jean M. Moran, James A. Hayman, Nithya Ramnath, Milton D. Gross, Xu-Wei Cai, Kirk A. Frey, Feng-Ming Spring Kong, Avraham Eisbruch, Randall K. Ten Haken
Publikováno v:
International Journal of Radiation Oncology*Biology*Physics. 82:e631-e638
This study aimed to (1) examine changes in dyspnea, global pulmonary function test (PFT) results, and functional activity on ventilation (V)/perfusion (Q) single-photon emission computerized tomography (SPECT) scans during the course of radiation (RT
Autor:
James A. Hayman, Xu-Wei Cai, S. Yuan, Kirk A. Frey, Avraham Eisbruch, Feng-Ming Spring Kong, Jeffrey L. Curtis, Randall K. Ten Haken, Nithya Ramnath, D. Arenberg, Milton D. Gross, Gregory P. Kalemkerian
Publikováno v:
Journal of Thoracic Oncology. 6:71-78
Introduction: Perfusion (Q) single photon emission computed tomography (SPECT) has been used to divert dose away from higher-functioning lung during radiation therapy (RT) planning. This study aimed to (1) study regional lung function through coregis
Autor:
Antoinette J. Wozniak, Bryan J. Schneider, Nithya Ramnath, Shirish M. Gadgeel, John C. Ruckdeschel, Francis P. Worden, Wei Chen, Xiaohui Zhang, Gregory P. Kalemkerian, Michael J. Kraut
Publikováno v:
Clinical Lung Cancer. 11:223-227
Background The prognosis for patients with extensive-stage small-cell lung cancer remains poor. This trial was designed to evaluate irinotecan/cisplatin plus maintenance imatinib in patients with c-Kit–positive disease (the transmembrane receptor c