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Publikováno v:
Biochemical Pharmacology. 86:1614-1620
The present study was aimed at assessing the influence of noradrenergic innervation of the paraventricular nucleus (PVN) and the arcuate nucleus (ARC) of the brain hypothalamus on cytochrome P450 expression in the liver. DSP-4, a neurotoxin specific
Publikováno v:
Neuropharmacology. 47:1-8
The effect of the group II metabotropic receptor agonist (-)-2-oxa-4-aminobicyclo[3.1.0]hexane-4,6-dicarboxylate (LY379268), on basal and phencyclidine-induced dopamine efflux were measured in the shell and core subdivisions of the nucleus accumbens-
Publikováno v:
Brain Research. 737:215-220
Ibogaine (IBO) is an indole alkaloid that is reported to facilitate drug abstinence in substance abusers. Despite considerable investigation, the mechanism of IBO action in vivo and its suitability as a treatment for drug addiction remains unclear. T
Publikováno v:
Pharmacology Biochemistry and Behavior. 52:29-34
The role of central monoamines in the genetically determined influences on voluntary ethanol consumption were examined by studying the extracellular levels of monoamines in the nucleus accumbens of the alcohol-preferring AA (Alko Alcohol) and alcohol
Publikováno v:
Pharmacology Biochemistry and Behavior. 49:759-762
In the present study, we investigated whether functional adaptational changes in the serotonergic neurotransmitter mechanisms regulating food intake following long-term lithium treatment in Fawn-Hooded rats (a rat strain suggested to represent a gene
Autor:
Jeffery D. Steketee, Barbara A. Sorg
Publikováno v:
Progress in Neuro-Psychopharmacology and Biological Psychiatry. 16:1003-1012
Rats pretreated with repeated footshock demonstrated an augmentation in cocaine-induced locomotor activity and extracellular dopamine concentrations in the nucleus accumbens. Pertussis toxin injections into the A10 region also led to cocaine- induced
Publikováno v:
European Journal of Pharmacology. 218:287-293
4-Methylaminorex is an amphetamine analog which has recently gained attention due to its potential as a stimulant of abuse and the ease with which it is synthesized. Administration of acute and multiple doses of 4-methylaminorex caused rapid (3-h) an
Autor:
Christer Nilsson, Elias Eriksson
Publikováno v:
European Journal of Pharmacology. 218:205-211
(-)-(3-Hydroxyphenyl)-N-n-propylpiperidine ((-)-3-PPP) and transdihydrolisuride (terguride, TDHL) are partial dopamine D2 receptor agonists displaying low intrinsic activity at normosensitive postsynaptic dopamine D2 receptors in brain while activati
Autor:
Patricia A. Broderick
Publikováno v:
Pharmacology, Biochemistry, and Behavior
Pharmacology Biochemistry and Behavior
Pharmacology Biochemistry and Behavior
The effect of subcutaneous (SC) cocaine (20 mg/kg) on synaptic concentrations of the biogenic amines, dopamine (DA), and serotonin (5-HT) in Ventral Tegmental Area, (VTA-[A10]) was studied in freely moving and behaving rats (rattus norvegicus) with i
Autor:
Claus Braestrup, Peter H. Andersen, Erling Guddal, Erik B. Nielsen, Frederik Christian Gronvald, Louis Brammer Hansen, Rolf Hohlweg
Publikováno v:
European Journal of Pharmacology. 219:45-52
The neurochemical properties of three novel benzazepine derivatives NNC-112, NNC-687 and NNC-756 were assessed. These compounds inhibited dopamine D1 receptor binding in vitro with low nanomolar to picomolar dissociation constants whereas those for t