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Autor:
Yonggang Cao, Hanping Qi, Shu Zhang, Pilong Shi, Yongsheng Liu, Yunping Chen, Chao Song, Lixin Wang, Hongli Sun, Jing Ren
Publikováno v:
Mol Ther
Emerging evidence reveals that autophagy plays crucial roles in cardiac hypertrophy. Long noncoding RNAs (lncRNAs) are novel transcripts that function as gene regulators. However, it is unclear whether lncRNAs regulate autophagy in cardiac hypertroph
Autor:
Junling Wang, Minako Ogawa-Tominaga, Jianing Wang, Weihua Zhang, Fang Fang, Xiaohui Wang, Kei Murayama, Victor Wei Zhang, Masaru Shimura, Li Zhang, Wei Shi, Junlan Lv, Zhimei Liu
Publikováno v:
Mitochondrion. 57:222-229
Childhood-onset dystonia with optic atrophy and basal ganglia abnormalities is an extremely rare autosomal recessive mitochondrial disease caused by biallelic mutations in MECR. Using whole-exome sequencing, we identified a novel homozygous MECR muta
Autor:
Camila Diedrich, Najeh Maissar Khalil, Christiane Schineider Machado, Emilli Antônio, Osmar dos Reis Antunes Junior, Rubiana Mara Mainardes, Juliane da Silva Santos, Rossana Gabriela Del Jesus Vásquez Marcano
Publikováno v:
International Journal of Biological Macromolecules. 172:133-142
Ursolic acid (UA) is a naturally occurring triterpene that has been investigated for its antitumor activity. However, its lipophilic character hinders its oral bioavailability, and therapeutic application. To overcome these limitations, chitosan (CS)
Publikováno v:
Biochemical and Biophysical Research Communications. 545:195-202
Epilepsy is accompanied by abnormal neurotransmission, and microRNAs, as versatile players in the modulation of gene expression, are important in epilepsy pathology. Here, we found that miR-128 expression was elevated in the acute seizure phase and d
Publikováno v:
International Journal of Biological Macromolecules. 172:263-269
In insects, the cytochrome P450 CYP6B family plays key roles in the detoxification of toxic plant substances. However, the function of CYP6 family genes in degrading plant toxicants in Tribolium castaneum, an extremely destructive global storage pest
Autor:
Anna Caciotti, Maja Di Rocco, Giulia Forni, Davide Mei, Angelica Rampazzo, Giancarlo la Marca, Rodolfo Tonin, Elena Procopio, Miriam Rigoldi, Antonio Andaloro, Renzo Guerrini, Amelia Morrone, Daniela Antuzzi, Lucrezia Cellai
Publikováno v:
Molecular Genetics and Metabolism. 132:180-188
Morquio B disease is an attenuated phenotype within the spectrum of beta galactosidase (GLB1) deficiencies. It is characterised by dysostosis multiplex, ligament laxity, mildly coarse facies and heart valve defects due to keratan sulphate accumulatio
Autor:
Anup Ramachandran, David S Umbaugh, Hartmut Jaeschke, Kuo Du, Jephte Y. Akakpo, Nga T. Nguyen
Publikováno v:
Toxicol Lett
Acetaminophen (APAP) overdose is the most common cause of acute liver failure in the United States and formation of APAP-protein adducts, mitochondrial oxidant stress and activation of the mitogen activated protein (MAP) kinase c-jun N-terminal kinas
Publikováno v:
International Journal of Biological Macromolecules. 173:341-350
The wide industrial cultivation of Pleurotus eryngii (P. eryngii) has resulted in the massive production of mushroom residues (MR) with low-efficiency utilization. In the present study, the P. eryngii enzymatic residue polysaccharide (PERP) was obtai
Autor:
Ziyuan Yang, Yanqing Li, Sheng Jin, Yuming Wu, Ying Li, Rui Yang, Chenxi Liu, Wei Hao, Haigang Geng, Xu Teng, Yuqing Li, Xiaoning Wang
Publikováno v:
Journal of Molecular and Cellular Cardiology. 152:17-28
Aims Apelin is the endogenous ligand of G protein-coupled receptor APJ and play an important role in the regulation of cardiovascular homeostasis. We aimed to investigate whether apelin ameliorates vascular calcification (VC) by inhibition of endopla
Autor:
Megha N. Karemore, Nikhil Bali
Publikováno v:
International Journal of Biological Macromolecules. 174:424-439
Cilnidipine, a fourth-generation both L-and N-type calcium channel blocker (CCB) is safe and effective in lowering blood-pressure without reflex tachycardia compared to other dihydropyridine CCBs. However, its low solubility coupled with extensive fi