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Autor:
Rafael C. Dutra, Jaíne Ferrareis Menegasso, Tatiana Pineda Vásquez, Nayara Alves Celinca Moraes, Regina Vasconcellos Antônio, Francielly Andressa Felipetti
Publikováno v:
International Journal of Biological Macromolecules. 194:402-411
The main objective of this study was to investigate the effects of bacterial cellulose hydrogel (BCH) incorporated into montmorillonite (MMT) and its underlying mechanisms of action on a skin wound healing mouse model following pressure injury model.
Autor:
Hossein Ghafouri, Samad Muhammadnejad, H. Delavari, Nastaran Moradi, Mohammad Ali Oghabian, Negin Pournoori
Publikováno v:
International Journal of Biological Macromolecules. 192:72-81
The conjugation of monoclonal antibodies with superparamagnetic iron oxide nanoparticles (SPIONs) has appeared as a potential multifunctional clinical tool, which can effectively diagnose cancers and monitor their treatment, specifically. Despite the
Publikováno v:
International Journal of Biological Macromolecules. 192:241-249
Intestinal epithelial cells (IECs) offer a primary physical barrier against commensal and pathogenic microorganisms in the gastrointestine. However, the influence of IECs on the development and regulation of mucosal immunity to infection is unknown.
Autor:
Sommaya M. Sharaf, Ibrahim M. El-Sherbiny, El-Sayed M. El-Sayed, Saif El-Din Al-Mofty, Ahmed S. Abo Dena, Amina Omar
Publikováno v:
International Journal of Biological Macromolecules. 193:2029-2037
Every year, about 1 out of 9 get burnt in Egypt, with a mortality rate of 37%, and they suffer from physical disfigurement and trauma. For the treatment of second-degree burns, we aim at making a smart bandage provided with control of drug release (u
Autor:
Farah Khan, Ashif Iqubal, Ozair Alam, Kanchan Kohli, Nikita Mehra, Gaurav Kumar Jain, Nematullah, Yub Raj Neupane, Reshal Suri
Publikováno v:
International Journal of Biological Macromolecules. 191:548-559
The usefulness of sirolimus (SIR) in the treatment of diseases that involve retinal degeneration like age-related macular degeneration (AMD) has been well documented. However, the problem still remains probably owing to the peculiar environment of th
Publikováno v:
International Journal of Biological Macromolecules. 191:1228-1239
In this study, we chemically modified poly(L-lactic acid) (PLLA) with functional amine groups and fabricated a PLLA membrane crosslinked with genipin as a biomembrane for inducing guided bone regeneration (GBR). The mechanical strength of the PLLA-am
Publikováno v:
Biochemical and Biophysical Research Communications. 579:62-68
Urocanic acid (UCA) is an endogenous small molecule that is elevated in skin, blood and brain after sunlight exposure, mainly playing roles in the periphery systems. Few studies have investigated the role of UCA in the central nervous system. In part
Autor:
Tian Wu, Siqi Liu, Weiwei Miao, Mengting Jia, Zupeng Luo, Lei Zhou, Jingsu Yu, Tengda Huang, Ziyi Song, Peng Wang, Lin Yu, Haojie Zhang, Yixing Li
Publikováno v:
Biochemical and Biophysical Research Communications. 575:20-27
Non-alcoholic fatty liver disease (NAFLD) is a common disease with a multitude of complications. Increasing evidence shows that the dietary supplement with betaine, a natural chemical molecule, can effectively reduce the fat accumulation in the liver
Autor:
Srinivas Mutalik, Shivanand H. Nannuri, Anita P. Vincent, Sajan D. George, Ruchira Raychaudhuri, Alex Joseph, Abhijeet Pandey, Subham Das
Publikováno v:
International Journal of Biological Macromolecules. 189:100-113
In the present work, lactoferrin (Lf) based nanoparticle incorporated self-supporting gel encapsulating a flavonoid, quercetin (Q), was developed. The complex formation between Lf and Q was assessed using molecular docking and dynamics simulation tha
Autor:
Aurelie Pac-Soo, Lin Chen, Daqing Ma, Hailin Zhao, Qian Chen, Shanglong Yao, You Shang, Azeem Alam
Publikováno v:
Laboratory Investigation; a Journal of Technical Methods and Pathology
Epithelial–mesenchymal transition (EMT) plays a crucial role in the development of pulmonary fibrosis. This study aims to investigate the effects of valproic acid (VPA) on EMT in vitro and in vivo. In vitro, EMT was induced by the administration of