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Autor:
Philippe Ruszniewski, Tahir Shah, Ulrich Frank Pape, Aude Houchard, Marianne Pavel, C. Lombard-Bohas, Xuan-Mai Truong Thanh, Francesco Panzuto, Ivan Borbath, Jarosław B. Ćwikła, Jaume Capdevila
Publikováno v:
Scientia
European journal of cancer (Oxford, England : 1990), Vol. 157, no.157, p. 403-414 (2021)
European journal of cancer (Oxford, England : 1990), Vol. 157, no.157, p. 403-414 (2021)
Lanreotide; Progression-free survival; Somatostatin Lanreótido; Supervivencia libre de progresión; Somatostatina Lanreòtid; Supervivència lliure de progressió; Somatostatina Introduction This prospective, single-arm, phase 2 study assessed the e
Publikováno v:
Toxicology Letters. 350:171-184
Recent studies have reported that melamine can accumulate in several regions of the brain including the medial prefrontal cortex (mPFC). Although melamine accumulation in the hippocampus has been verified to induce cognitive impairments, whether it c
Publikováno v:
NeuroToxicology. 86:114-124
Neuroprotective effect of astaxanthin-s-allyl cysteine diester (AST-SAC) against high glucose (HG)-induced oxidative stress in in vitro and cognitive decline under diabetes conditions in in vivo has been explored. Pretreatment of AST-SAC (5, 10 and 1
Autor:
Mark Reedy, Komaraiah Palle, Chiquito J. Crasto, Rodney P. Rocconi, Chinnadurai Mani, Ranganatha R. Somasagara, Mohammad Athar, Kaushlendra Tripathi, Sandeep C. Chaudhary
Publikováno v:
Neoplasia (New York, N.Y.)
Neoplasia: An International Journal for Oncology Research, Vol 23, Iss 9, Pp 1002-1015 (2021)
Neoplasia: An International Journal for Oncology Research, Vol 23, Iss 9, Pp 1002-1015 (2021)
Ovarian cancer (OC) is one of the most lethal type of cancer in women due to a lack of effective targeted therapies and high rates of treatment resistance and disease recurrence. Recently Poly (ADP-ribose) polymerase inhibitors (PARPi) have shown pro
Autor:
Daniel Khalaf, Maryam Soleimani, Werner Struss, Daygen Finch, Katherine Sunderland, Joanna Vergidis, Kevin Zou, Christian Kollmannsberger, Krista Noonan, B.J. Eigl, Muhammad Zulfiqar, Kim N. Chi, Lucia Nappi
Publikováno v:
European Journal of Cancer. 152:215-222
Metastatic castration-resistant prostate cancer (mCRPC) disproportionately affects the elderly. There is limited data assessing the efficacy and tolerability of abiraterone acetate (AA) versus enzalutamide in this population.To compare the clinical e
Autor:
Rod Partow-Navid, Dante Garcia, Gary E. Fraser, Joshua Coney, Dmitry Abramov, Purvi Parwani, Liset Stoletniy, Antoine Sakr, Dennis Grewal
Publikováno v:
The American Journal of Cardiology. 151:64-69
Despite significant advances in evidence-based treatments for heart failure with reduced ejection fraction (HFrEF), the use of guideline directed medical therapy (GDMT) at recommended doses remains suboptimal. We examine the usage and modification of
Publikováno v:
Brain Research Bulletin. 172:120-128
A modulatory role has been reported for the isoflavone, genistein, on voltage-gated Na+ channels in the trigeminal ganglion in vitro. However, the acute effects of genistein in vivo, particularly on nociceptive transmission in the trigeminal system,
Autor:
Marina Prigol, Rafael Roehrs, Elize Aparecida Santos Musachio, Dieniffer Espinosa Janner, Bruna Piaia Ramborger, Jocemara Corrêa Reginaldo, Elen Caroline de Matos Amador, Francielli Polet de Almeida, Gustavo Petri Guerra, Kétnne Hanna Poleto, Márcia Rósula Poetini, Nathalie Savedra Gomes
Publikováno v:
NeuroToxicology. 85:79-89
Neurodevelopmental disorders, such as Autism Spectrum Disorder (ASD) and Attention Deficit Hyperactivity Disorder (ADHD) are responsible for behavioral deficits in children. Imidacloprid is a nicotinic acetylcholine receptor agonist, capable of causi
Publikováno v:
Heart Rhythm. 18:1186-1191
Background Arrhythmogenic right ventricular cardiomyopathy (ARVC) is an important cause of sudden cardiac death in young people and athletes. To date, no treatment has proven to slow the progression of the disease. Preload reducing agents such as nit
Autor:
Masood A. Khan, Karen Brown, Michael A. Malfatti, Edwina N. Scott, William P. Steward, Emma Parrott, Robert G. Britton, Ted J. Ognibene, Hong Cai
Publikováno v:
The American Journal of Clinical Nutrition
Background The dietary polyphenol resveratrol prevents various malignancies in preclinical models, including prostate cancer. Despite attempts to translate findings to humans, gaps remain in understanding pharmacokinetic-pharmacodynamic relations and