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Autor:
Michael R. Hicks, April D. Pyle
Publikováno v:
Trends in cell biology, vol 33, iss 2
Stem cell niches are composed of dynamic microenvironments that support stem cells over a lifetime. The emerging niche is distinct from the adult because its main role is to support the progenitors that build organ systems in development. Emerging ni
Autor:
Myriam Lemmens, Juliane Perner, Leon Potgeter, Michael Zogg, Sineha Thiruchelvam, Matthias Müller, Thierry Doll, Annick Werner, Yoann Gilbart, Philippe Couttet, Hans-Jörg Martus, Silvana Libertini
Publikováno v:
Cytotherapy. 25:59-67
Engineered tissues and cell therapies based on human induced pluripotent stem cells (iPSCs) represent a promising approach for novel medicines. However, iPSC-derived cells and tissues may contain residual undifferentiated iPSCs that could lead to ter
Publikováno v:
Seminars in Cell & Developmental Biology. 133:123-134
Stem cells can generate a diversity of cell types during development, regeneration and adult tissue homeostasis. Differentiation changes not only the cell fate in terms of gene expression but also the physical properties and functions of cells, e.g.
Publikováno v:
Differentiation. 128:67-82
Macrophages derived from human monocytic leukemia THP-1 cell line are often used as the alternative of human primary macrophage. However, the polarization method of THP-1 to macrophages varies between different laboratories, which may unknowingly aff
Autor:
Dafni Chondronasiou, Jaime Martínez de Villarreal, Elena Melendez, Cian J. Lynch, Natalia del Pozo, Marta Kovatcheva, Mònica Aguilera, Neus Prats, Francisco X. Real, Manuel Serrano
Publikováno v:
Dipòsit Digital de la UB
Universidad de Barcelona
Universidad de Barcelona
Differentiated cells can be converted into pluripotent stem cells by expressing the transcription factors OCT4, SOX2, KLF4, and MYC (OSKM) in a process known as reprogramming. Here, using single-cell RNA sequencing of pancreas undergoing reprogrammin
Autor:
Shiwen Deng, Tong Lei, Hongyu Chen, Huiting Zheng, Zhuangzhuang Xiao, Shanglin Cai, Zhongci Hang, Weini Xiong, Yanqing Yu, Xiaoshuang Zhang, Yanjie Yang, Wangyu Bi, Hongwu Du
Publikováno v:
Cytotherapy. 24:1095-1104
Stem cells from human exfoliated deciduous teeth (SHED) play a significant role in tissue engineering and regenerative medicine. Angiogenesis is crucial in tissue regeneration and a primary target of regenerative medicine. As a first-line anti-diabet
Autor:
Kristijonas Žemaitis, Agatheeswaran Subramaniam, Roman Galeev, Aurel Prosz, Maria Jassinskaja, Jenny Hansson, Jonas Larsson
Publikováno v:
Experimental Hematology. 115:20-29
The molecular mechanisms regulating key fate decisions of hematopoietic stem cells (HSCs) remain incompletely understood. Here, we targeted global shRNA libraries to primary human hematopoietic stem and progenitor cells (HSPCs) to screen for modifier
Autor:
Sudhanshu Yadav, Antonio Garrido, M. Carmen Hernández, Juan C. Oliveros, Vicente Pérez-García, Mario F. Fraga, Ana C. Carrera
Publikováno v:
WOS:000873961800006
The mechanism governing the transition of human embryonic stem cells (hESCs) toward differentiated cells is only partially understood. To explore this transition, the activity and expression of the ubiquitous phosphatidylinositol 3-kinase (PI3Kα and
Publikováno v:
Stem Cell Reports. 17:2167-2171
In a recently published study, Xu et al. used two surface markers, CLSTN2 and PTPRO, to generate highly purified donor dopaminergic neurons and achieved stable and predictable therapeutic outcomes by transplantation into the brain of PD animal models
Autor:
Bayardo I. Garay, Sophie Givens, Phablo Abreu, Man Liu, Doğacan Yücel, June Baik, Noah Stanis, Taylor M. Rothermel, Alessandro Magli, Juan E. Abrahante, Natalya A. Goloviznina, Hossam A.N. Soliman, Neha R. Dhoke, Michael Kyba, Patrick W. Alford, Samuel C. Dudley, Jop H. van Berlo, Brenda Ogle, Rita R.C. Perlingeiro
Publikováno v:
Stem Cell Reports. 17:2005-2022
Human induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CMs) provide great opportunities for mechanistic dissection of human cardiac pathophysiology; however, hiPSC-CMs remain immature relative to the adult heart. To identify novel signalin