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Publikováno v:
Differentiation. 128:67-82
Macrophages derived from human monocytic leukemia THP-1 cell line are often used as the alternative of human primary macrophage. However, the polarization method of THP-1 to macrophages varies between different laboratories, which may unknowingly aff
Autor:
Kristijonas Žemaitis, Agatheeswaran Subramaniam, Roman Galeev, Aurel Prosz, Maria Jassinskaja, Jenny Hansson, Jonas Larsson
Publikováno v:
Experimental Hematology. 115:20-29
The molecular mechanisms regulating key fate decisions of hematopoietic stem cells (HSCs) remain incompletely understood. Here, we targeted global shRNA libraries to primary human hematopoietic stem and progenitor cells (HSPCs) to screen for modifier
Publikováno v:
Biochemical and Biophysical Research Communications. 619:27-33
Transcription factors are key determinants of lineage commitment during mammalian development. However, the function and molecular mechanism for the transcription factors in the formation of three primary germ layers during human embryonic developmen
Publikováno v:
Biochemical and Biophysical Research Communications. 618:100-106
Regeneration of periodontal hard tissues damaged by Porphyromonas gingivalis (P. gingivalis) is essential for tooth stability and dental health. Irisin, a myokine secreted by skeletal muscle, is involved in different biological processes, such as myo
Publikováno v:
Biochemical and Biophysical Research Communications. 606:174-181
Brown adipocytes have been linked to managing human obesity and related metabolic diseases. A large number of natural products have emerged that can activate brown adipocytes tissue (BAT) to active thermogenesis, but the epigenetic mechanisms have no
Publikováno v:
Biochemical and Biophysical Research Communications. 603:49-56
The stepwise development of bone is rigidly controlled from mesenchymal cells through osteoblasts. Dysregulation of this process causes various bone diseases, such as osteoporosis and osteogenesis imperfecta. Recently, it has been noted that the decr
Publikováno v:
Biochemical and Biophysical Research Communications. 606:108-113
CD99 is a glycoprotein primarily expressed in immune cells. Physiologically, it is involved in the adhesion, migration, and development of immune cells. The presence of CD99 in the skin was first reported in 2016 and its function is yet to be determi
Autor:
Karl-Heinz, Klempnauer
Publikováno v:
Experimental Hematology. 108:8-15
Transcription factor MYB is a key regulator of gene expression in hematopoietic cells and has emerged as a novel drug target for acute myeloid leukemia (AML). Studies aiming to identify potential MYB inhibitors have found that the natural compound he
Autor:
Yusuke Kawamura, Tetsuro Hida, Bisei Ohkawara, Masaki Matsushita, Takeshi Kobayashi, Shinya Ishizuka, Hideki Hiraiwa, Satoshi Tanaka, Mikito Tsushima, Hiroaki Nakashima, Kenyu Ito, Shiro Imagama, Mikako Ito, Akio Masuda, Naoki Ishiguro, Kinji Ohno
Publikováno v:
Biochemical and Biophysical Research Communications. 592:87-92
We screened pre-approved drugs for the survival of the Hu5/KD3 human myogenic progenitors. We found that meclozine, an anti-histamine drug that has long been used for motion sickness, promoted the proliferation and survival of Hu5/KD3 cells. Meclozin
Autor:
Yu-Han Chang, Po-Liang Lai, Ya-Hui Lin, Hsiang-Sheng Lee, Yelena V. Parfyonova, Mikhail Menshikov, Chin-Wei Chang, Nuong Thi Kieu Nguyen, Vu Anh Truong, Jaw Ching Wu, Yu-Chen Hu, Nam Ngoc Pham, Yi-Hao Chang, Chih-Che Shen, Mu-Nung Hsu
Publikováno v:
Mol Ther
Calvarial bone healing is challenging, especially for individuals with osteoporosis because stem cells from osteoporotic patients are highly prone to adipogenic differentiation. Based on previous findings that chondrogenic induction of adipose-derive