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Autor:
Mutsumi Kobayashi, Misato Kobayashi, Junko Odajima, Keiko Shioda, Young Sun Hwang, Kotaro Sasaki, Pranam Chatterjee, Christian Kramme, Richie E. Kohman, George M. Church, Amanda R. Loehr, Robert S. Weiss, Harald Jüppner, Joanna J. Gell, Ching C. Lau, Toshi Shioda
Publikováno v:
Stem Cell Reports. 17:507-521
In vitro expansion of human primordial germ cell-like cells (hPGCLCs), a pluripotent stem cell-derived PGC model, has proved challenging due to rapid loss of primordial germ cell (PGC)-like identity and limited cell survival/proliferation. Here, we d
Autor:
Yusuke Kawamura, Tetsuro Hida, Bisei Ohkawara, Masaki Matsushita, Takeshi Kobayashi, Shinya Ishizuka, Hideki Hiraiwa, Satoshi Tanaka, Mikito Tsushima, Hiroaki Nakashima, Kenyu Ito, Shiro Imagama, Mikako Ito, Akio Masuda, Naoki Ishiguro, Kinji Ohno
Publikováno v:
Biochemical and Biophysical Research Communications. 592:87-92
We screened pre-approved drugs for the survival of the Hu5/KD3 human myogenic progenitors. We found that meclozine, an anti-histamine drug that has long been used for motion sickness, promoted the proliferation and survival of Hu5/KD3 cells. Meclozin
Publikováno v:
Trends Endocrinol Metab
The Notch signaling pathway is conserved among mammalian species and controls proliferation, differentiation, and cell death in many organs throughout the body including the reproductive tract. Notch signaling plays critical roles in the development
Autor:
Jalaj Garg, Milind Mahajan, Nicole Dubois, Kristin G. Beaumont, Katherine C. Michelis, Marc R. Birtwistle, Seth I. Berger, Joseph Goldfarb, Jason C. Kovacic, David C. Thomas, Marc A. Miller, Bino Mathew, Priyanka Dhanan, Teeya Raghunandan, Evren U. Azeloglu, Ravi Iyengar, Joseph Tripodi, Himali Weerahandi, Christoph Schaniel, Rafael Dariolli, Jens Hansen, Moara Machado, Gomathi Jayaraman, Stephan C. Schürer, Colleen S. Lynch, Bin Hu, David M. Gonzalez, Dusica Vidovic, Sunita L. D’Souza, Vesna Najfeld, Arjun Singh Yadaw, Eric A. Sobie, Neelima C. Tangirala, Eric E. Schadt, Yuguang Xiong, Robert Sebra
Publikováno v:
Stem Cell Reports
Summary A library of well-characterized human induced pluripotent stem cell (hiPSC) lines from clinically healthy human subjects could serve as a useful resource of normal controls for in vitro human development, disease modeling, genotype-phenotype
Autor:
Qianqian Qiu, Qingqing Yuan, Liping Wen, Zheng Li, Min Sun, Wei Chen, Wenhui Zhang, Fan Zhou, Yinghong Cui, Zuping He
Publikováno v:
Stem Cell Reports
Summary We propose a new concept that human somatic cells can be converted to become male germline stem cells by the defined factors. Here, we demonstrated that the overexpression of DAZL, DAZ2, and BOULE could directly reprogram human Sertoli cells
Autor:
Asami Akita, Yasushi Ototake, Tomoya Watanabe, Noriko Komitsu, Tomohiko Tamura, Yukie Yamaguchi, Michiko Aihara, Daisuke Kurotaki, Miho Asami, Miwa Kanaoka
Publikováno v:
Journal of Investigative Dermatology. 141:1954-1963
Monocytes and macrophages may be involved in the pathogenesis of systemic sclerosis (SSc); however, the etiology and regulation of monocyte and macrophage function in SSc remain unknown. IRF8 is a transcriptional regulator that is essential for the d
Autor:
Zhenlin Hu, Lusheng Wang, Keke Guo, Yu Chen, Shuang Gao, Nuo Xu, Chengliang Li, Jungang Zhao, Rongrong Jing, Xuenan Li
Publikováno v:
International Journal of Biological Macromolecules. 185:876-889
The integrity of the epidermal barrier and the maintenance of barrier homeostasis depend on the dynamic balance between the proliferation and differentiation of keratinocytes. Calcium (Ca2+) plays a crucial role in maintaining a balance of these two
Human Bronchial Epithelial Cell Growth on Homologous Versus Heterologous Tissue Extracellular Matrix
Autor:
William D'Angelo, Scott A. Johnson, Stephen F. Badylak, Li Zhang, Janet E. Reing, Michael M. Myerburg, Anjani K. Ravindra
Publikováno v:
J Surg Res
Background Extracellular matrix (ECM) bioscaffolds produced by decellularization of source tissue have been effectively used for numerous clinical applications. However, decellularized tracheal constructs have been unsuccessful due to the immediate r
Autor:
Hang Lei, Shuang Tao, Meng-Chun Huang, Yan-Xia Hu, Shu-Juan Xie, Li-Ting Diao, Zhen Dong Xiao, Ya-Rui Hou, Qi Zhang, Xiusheng Qiu, Yu-Jia Sun
Publikováno v:
Biochemical and Biophysical Research Communications. 552:52-58
METTL3 increasing the mature miRNA levels via N6-Methyladenosine (m6A) modification of primary miRNA (pri-miRNA) transcripts has emerged as an important post-transcriptional regulation of miRNA biogenesis. Our previous studies and others have showed
Publikováno v:
Stem Cell Reports
Summary Identifying lineage-specific markers is pivotal for understanding developmental processes and developing cell therapies. Here, we investigated the functioning of a cardiomyogenic cell-surface marker, latrophilin-2 (LPHN2), an adhesion G-prote