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Autor:
Yoon Jeong Choi, Seok Jun Moon, Kim Euiseong, Sunil Dds. Kim, Ji Hyun Lee, Dong Min Shin, Dongzi Chen, Sukjoon Lee, Munsu Park
Publikováno v:
Journal of Endodontics. 48:240-248
Many studies have investigated the transcriptome profiles of dental stem cells for regenerative medicine. However, such studies use bulk RNA and do not consider cell-level heterogeneity. Here, we investigated the characteristics and heterogeneity of
Autor:
Jalaj Garg, Milind Mahajan, Nicole Dubois, Kristin G. Beaumont, Katherine C. Michelis, Marc R. Birtwistle, Seth I. Berger, Joseph Goldfarb, Jason C. Kovacic, David C. Thomas, Marc A. Miller, Bino Mathew, Priyanka Dhanan, Teeya Raghunandan, Evren U. Azeloglu, Ravi Iyengar, Joseph Tripodi, Himali Weerahandi, Christoph Schaniel, Rafael Dariolli, Jens Hansen, Moara Machado, Gomathi Jayaraman, Stephan C. Schürer, Colleen S. Lynch, Bin Hu, David M. Gonzalez, Dusica Vidovic, Sunita L. D’Souza, Vesna Najfeld, Arjun Singh Yadaw, Eric A. Sobie, Neelima C. Tangirala, Eric E. Schadt, Yuguang Xiong, Robert Sebra
Publikováno v:
Stem Cell Reports
Summary A library of well-characterized human induced pluripotent stem cell (hiPSC) lines from clinically healthy human subjects could serve as a useful resource of normal controls for in vitro human development, disease modeling, genotype-phenotype
Publikováno v:
Journal of Bioscience and Bioengineering. 132:390-398
The dynamic migratory behavior of human mesenchymal stem cells (hMSCs) has a significant impact on the epigenetic profiles that determine fate choice and lineage commitment during differentiation. Here we report a novel approach to enhance repeated m
Autor:
Atsushi Tsuchida, Hirai Kakuro, Sayaka Sekiya, Kenji Yoshida, Akiyoshi Kishino, Saito Hikaru, Atsushi Nakane, Masaharu Kiyama, Jun Takahashi, Shizu Takeda, Kunio Ohyama, Toru Kimura, Hiroko Hanzawa, Midori Kato
Publikováno v:
Journal of Bioscience and Bioengineering. 132:381-389
To improve cell production efficacy, it is important to evaluate cell conditions during culture. Extracellular vesicles (EVs) secreted from various cells are involved in stem cell differentiation. As EVs carry information about their source cells, we
Autor:
Mikael Wiberg, Paul J. Kingham, Maria Brohlin, Peyman Kelk, Rebecca Wiberg, Anne Therese Lauvrud, Rojda Gümüscü
Publikováno v:
Journal of Plastic, Reconstructive & Aesthetic Surgery. 74:2759-2767
Summary Introduction Water jet-assisted liposuction has gained popularity due to favourable fat grafting outcomes. In this study, we compared stem cells obtained from fat isolated with manual or the water jet-assisted procedure. Methods Liposuction o
Autor:
Masazumi Tada
Publikováno v:
Developmental Biology. 477:1-10
Cell extrusion is a morphogenetic process in which unfit or dying cells are eliminated from the tissue at the interface with healthy neighbours in homeostasis. This process is also highly associated with cell fate specification followed by differenti
Publikováno v:
Stem Cell Reports
Summary Identifying lineage-specific markers is pivotal for understanding developmental processes and developing cell therapies. Here, we investigated the functioning of a cardiomyogenic cell-surface marker, latrophilin-2 (LPHN2), an adhesion G-prote
Autor:
Vi T. Tang, Kathryn Ufford, Zhaowen Tong, Allen P. Liu, Sabrina Friedline, Stephanie L. Bielas, Adam S. Helms, Amani S. Dobbs, Yao-Chang Tsan
Publikováno v:
Stem Cell Reports
Summary Disease modeling and pharmaceutical testing using cardiomyocytes derived from induced pluripotent stem cells (iPSC-CMs) requires accurate assessment of contractile function. Micropatterning iPSC-CMs on elastic substrates controls cell shape a
Publikováno v:
Molecular Therapy. 29:1151-1163
Efficient differentiation of pluripotent stem cells (PSCs) into cardiac cells is essential for the development of new therapeutic modalities to repair damaged heart tissue. We identified a novel cell surface marker, the G protein-coupled receptor lys
Publikováno v:
SLAS Technology. 26:80-91
Over the past decade, induced pluripotent stem cells (iPSCs) have become a major focus of stem cell and developmental biology research, offering researchers a clinically relevant source of cells that are amenable to genetic engineering approaches. Th