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Publikováno v:
Biochemical and Biophysical Research Communications. 587:9-15
Objective The role of circadian clock in cementogenesis is unclear. This study examines the role of REV-ERBs, one of circadian clock proteins, in proliferation, migration and mineralization of cementoblasts to fill the gap in knowledge. Methods Expre
Autor:
Shi-Yan Ng, Jin-Hui Hor, Colin L. Stewart, Omer An, Lee Chuen Liew, Beatrice Xuan Ho, Hongbing Yu, Boon Seng Soh, Henry He Yang, Jeremy Kah Sheng Pang, Woon-Khiong Chan, Piotr Szyniarowski, Christina Ying Yan Lim
Publikováno v:
Stem Cell Reports
Summary The immature characteristics and metabolic phenotypes of human pluripotent stem cell-derived cardiomyocytes (hPSC-CMs) restrict their applications for disease modeling, drug discovery, and cell-based therapy. Leveraging on the metabolic shift
Autor:
Nimrod Buchbinder, Hassan Atmani, Jean-Pierre Vannier, Guy Ladam, Sandrine Morin-Grognet, Béatrice Labat
Publikováno v:
Acta Biomaterialia. 135:383-392
Neuroblastoma is the third most common pediatric cancer composed of malignant immature cells that are usually treated pharmacologically by all trans-retinoic acid (ATRA) but sometimes, they can spontaneously differentiate into benign forms. In that c
Publikováno v:
International Journal of Biological Macromolecules. 176:96-105
Epigallocatechin-3-gallate (EGCG) is a kind of flavonoids and has the ability to promote differentiation of mesenchymal stem cells (MSCs) into osteoblasts. However, the EGCG is easily metabolized by cells during cell culture, which reduces its bioava
Publikováno v:
Biochemical and Biophysical Research Communications. 534:310-316
Pancreatic ductal adenocarcinoma (PDAC) is an intractable malignancy for which novel therapeutic targets are in high demand. To uncover glycans expressed within PDAC, we previously performed glycome profiling of PDAC cell lines using lectin microarra
Publikováno v:
Stem Cell Reports
Human stem cells bear a great potential for multiple therapeutic applications but at the same time constitute a major threat to human health in the form of cancer stem cells. The molecular processes that govern stem cell maintenance or differentiatio
Publikováno v:
Differentiation. 115:1-10
The importance of oxygen tension in in vitro cultures and its effect on embryonic stem cell (ESC) differentiation has been widely acknowledged. Research has mainly focussed on ESC maintenance or on one line of differentiation and only few studies hav
Autor:
Kayo Kiyoi, Yoshikazu Haramoto, Tomoko Watanabe, Sayoko Saito, Shuuji Mawaribuchi, Hiroaki Tateno, Keiko Hiemori
Publikováno v:
Biochemical and Biophysical Research Communications. 529:575-581
Quality control for human induced pluripotent stem cells (hiPSCs) is important for efficient and stable production of hiPSC-derived cell therapy products to be used for transplantation. During cell culture, hiPSCs spontaneously undergo morphological
Autor:
Guizhi Sun, Jessica Hatwell-Humble, Šárka Lehtonen, Minna Oksanen, Jose M. Polo, Teresa H. Vandekolk, Jari Koistinaho, Colin W. Pouton, Alexandra Grubman, Jan Schröder, Cameron P.J. Hunt, Susan K. Nilsson, Jonathan M. Chan, John M. Haynes
Publikováno v:
Stem Cell Reports
Summary Multiple protocols have been published for generation of iMGLs from hESCs/iPSCs. To date, there are no guides to assist researchers to determine the most appropriate methodology for microglial studies. To establish a framework to facilitate f
Publikováno v:
Immunology Letters. 221:6-17
Background Red blood cells (RBCs) can have a modulatory effect on immune cells; so changes in their dynamism could considerably influence their physiology, and consequently the immune activities of neighbouring cells, like natural killer (NK) cells.