Zobrazeno 1 - 10
of 5 514
pro vyhledávání: ''
Autor:
Jiarui Wang, Xianqin Zhang, Tingting Zou, Dazhi Zhang, Wenqiang Liu, Zhenxing Liu, Xuejie Peng, Zhengyi Ni, Yang Tan, Meiqi Hou, Mi Zhou, Chao Yuan, Xiaopei Zhou
Publikováno v:
Biochemical and Biophysical Research Communications. 591:124-129
Mendelian susceptibility to mycobacterial disease (MSMD) is a rare monogenetic disease, which is characterized by susceptibility to some weakly virulent mycobacteria. Here, we explored the pathogenic genes and molecular mechanisms of MSMD patients. W
Autor:
Ruyi Xue, Shengxian Li, Ji-Cheng Li, Lai-Xi Wang, W.W. Zhang, Youping Li, T.Y. Mi, X.L. Yin, Yueming Zhang, Hai-Tao Wang, Xu Shen, Yan Zhang
Publikováno v:
Biochemical and Biophysical Research Communications. 586:121-128
Postoperative fatigue (POF) is the most common and long-lasting complication after surgery, which brings heavy burden to individuals and society. Recently, hastening postoperative recovery receives increasing attention, but unfortunately, the mechani
Autor:
Li Li, Glenda C. Gobe, David A. Vesey, Christudas Morais, Rajagopalan Prasanna, Evan P. Owens, Hossam Kamli
Publikováno v:
Biochemical and Biophysical Research Communications. 586:42-48
Sunitinib is one of the first-line multi-tyrosine kinase inhibitors for metastatic renal cell carcinoma, and resistance to sunitinib continues to be a limiting factor for the successful treatment. As interleukin-6 (IL-6) is overexpressed in sunitinib
Autor:
Ken Yasukawa, Yusuke Suzuki, Takehiko Yokomizo, Airi Jo-Watanabe, Toshiaki Okuno, Hyeon-Cheol Lee-Okada, Ryotaro Shioda
Publikováno v:
Biochemical and Biophysical Research Communications. 582:49-56
The efficacy of n-3 polyunsaturated fatty acids (PUFAs) in improving outcomes in a renal ischemia-reperfusion injury (IRI) model has previously been reported. However, the underlying mechanisms remain poorly understood and few reports demonstrate how
Publikováno v:
International Journal of Biological Macromolecules. 191:1228-1239
In this study, we chemically modified poly(L-lactic acid) (PLLA) with functional amine groups and fabricated a PLLA membrane crosslinked with genipin as a biomembrane for inducing guided bone regeneration (GBR). The mechanical strength of the PLLA-am
Publikováno v:
Biochemical and Biophysical Research Communications. 580:1-6
Sphingosine kinase 2 (SphK2) inhibitors are developed for tumor therapy as considering its anti-tumor effect. Many studies also explored SphK2 modulated glucose and lipid homeostasis, which extended its potential function for metabolic diseases thera
Publikováno v:
Biochemical and Biophysical Research Communications. 579:62-68
Urocanic acid (UCA) is an endogenous small molecule that is elevated in skin, blood and brain after sunlight exposure, mainly playing roles in the periphery systems. Few studies have investigated the role of UCA in the central nervous system. In part
Autor:
Tian Wu, Siqi Liu, Weiwei Miao, Mengting Jia, Zupeng Luo, Lei Zhou, Jingsu Yu, Tengda Huang, Ziyi Song, Peng Wang, Lin Yu, Haojie Zhang, Yixing Li
Publikováno v:
Biochemical and Biophysical Research Communications. 575:20-27
Non-alcoholic fatty liver disease (NAFLD) is a common disease with a multitude of complications. Increasing evidence shows that the dietary supplement with betaine, a natural chemical molecule, can effectively reduce the fat accumulation in the liver
Autor:
Srinivas Mutalik, Shivanand H. Nannuri, Anita P. Vincent, Sajan D. George, Ruchira Raychaudhuri, Alex Joseph, Abhijeet Pandey, Subham Das
Publikováno v:
International Journal of Biological Macromolecules. 189:100-113
In the present work, lactoferrin (Lf) based nanoparticle incorporated self-supporting gel encapsulating a flavonoid, quercetin (Q), was developed. The complex formation between Lf and Q was assessed using molecular docking and dynamics simulation tha
FSH mediated cAMP signalling upregulates the expression of Gα subunits in pubertal rat Sertoli cells
Autor:
Alka Gupta, Indrashis Bhattacharya, Bhola Shankar Pradhan, Souvik Sen Sharma, Hironmoy Sarkar, Subeer S. Majumdar
Publikováno v:
Biochemical and Biophysical Research Communications. 569:100-105
Follicle Stimulating Hormone (FSH) acts via FSH-Receptor (FSH-R) by employing cAMP as the dominant secondary messenger in testicular Sertoli cells (Sc) to support spermatogenesis. Binding of FSH to FSH-R, results the recruitment of the intracellular