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Publikováno v:
Biochemical and Biophysical Research Communications. 619:27-33
Transcription factors are key determinants of lineage commitment during mammalian development. However, the function and molecular mechanism for the transcription factors in the formation of three primary germ layers during human embryonic developmen
Publikováno v:
Biochemical and Biophysical Research Communications. 618:100-106
Regeneration of periodontal hard tissues damaged by Porphyromonas gingivalis (P. gingivalis) is essential for tooth stability and dental health. Irisin, a myokine secreted by skeletal muscle, is involved in different biological processes, such as myo
Publikováno v:
Biochemical and Biophysical Research Communications. 606:174-181
Brown adipocytes have been linked to managing human obesity and related metabolic diseases. A large number of natural products have emerged that can activate brown adipocytes tissue (BAT) to active thermogenesis, but the epigenetic mechanisms have no
Publikováno v:
Biochemical and Biophysical Research Communications. 603:49-56
The stepwise development of bone is rigidly controlled from mesenchymal cells through osteoblasts. Dysregulation of this process causes various bone diseases, such as osteoporosis and osteogenesis imperfecta. Recently, it has been noted that the decr
Publikováno v:
Biochemical and Biophysical Research Communications. 606:108-113
CD99 is a glycoprotein primarily expressed in immune cells. Physiologically, it is involved in the adhesion, migration, and development of immune cells. The presence of CD99 in the skin was first reported in 2016 and its function is yet to be determi
Autor:
Yusuke Kawamura, Tetsuro Hida, Bisei Ohkawara, Masaki Matsushita, Takeshi Kobayashi, Shinya Ishizuka, Hideki Hiraiwa, Satoshi Tanaka, Mikito Tsushima, Hiroaki Nakashima, Kenyu Ito, Shiro Imagama, Mikako Ito, Akio Masuda, Naoki Ishiguro, Kinji Ohno
Publikováno v:
Biochemical and Biophysical Research Communications. 592:87-92
We screened pre-approved drugs for the survival of the Hu5/KD3 human myogenic progenitors. We found that meclozine, an anti-histamine drug that has long been used for motion sickness, promoted the proliferation and survival of Hu5/KD3 cells. Meclozin
Publikováno v:
Biochemical and Biophysical Research Communications. 587:9-15
Objective The role of circadian clock in cementogenesis is unclear. This study examines the role of REV-ERBs, one of circadian clock proteins, in proliferation, migration and mineralization of cementoblasts to fill the gap in knowledge. Methods Expre
Simulated microgravity accelerates aging of human skeletal muscle myoblasts at the single cell level
Publikováno v:
Biochemical and Biophysical Research Communications. 578:115-121
Earth's gravity is essential for maintaining skeletal muscle mass and function in the body. The role of gravity in the myogenic mechanism has been studied with animal experiments in the International Space Station. Recently, gravity-control devices a
Publikováno v:
Biochemical and Biophysical Research Communications. 577:6-11
Premature ovarian failure (POF) is defined by amenorrhea, hypoestrogenism, elevated gonadotropin levels, and infertility. Chemotherapeutic agents are the most gonadotoxic agents that lead to POF. Although some previous studies have presented that mes
Autor:
Jinqi Wang, Haozhen Lv, Xuanhao Zeng, Yating Liu, Qi Zhang, Jinhua Xu, Weiling Lian, Kelu Wei
Publikováno v:
Biochemical and Biophysical Research Communications. 573:151-157
Although surgical interventions have become optional for refractory vitiligo, grafting related injuries is inevitable. Embryonic stem cell (ESC) derivatives can be used in transplantation to address this issue, but the immune rejection due to allogen