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Autor:
Nazima Dharsee, Abdolrahman S. Nateri, Amany Almars, Teddy Mselle, Ismael Adolf, Irene Jeremiah Nguma, Fatmahan Atalar, Gokce Akan
Publikováno v:
Genes & Diseases. 9:1220-1233
The immune system plays an important role in protecting the body against malignancy. During cancer immunoediting, the immune system can recognize and keep checking the tumor cells by down-expression of some self-molecules or by increasing expression
Autor:
Yesennia Sánchez-Pérez, Yolanda I. Chirino, Miguel Santibáñez-Andrade, Diddier Prada, Claudia M. García-Cuellar, Octavio Alonso Larraga, Dennis Cerrato-Izaguirre, Javier Camacho, Angélica Hernández-Guerrero
Publikováno v:
Genes & Diseases. 9:928-940
Latin-America (LATAM) is the second region in gastric cancer incidence; gastric adenocarcinoma (GA) represents 95% of all cases. We provide a mutational landscape of GA highlighting a) germline pathogenic variants associated with hereditary GA, b) ge
Autor:
Isabelle Touitou
Publikováno v:
Genes & Diseases. 9:1000-1007
Mevalonate kinase (MK)-associated diseases encompass a broad spectrum of rare auto-inflammatory conditions, all resulting from pathogenic variants in the mevalonate kinase gene (MVK). Their clinical manifestations are highly variable, ranging from mo
Publikováno v:
Journal of Investigative Dermatology. 142:1755-1758
Sezary syndrome (SS) is an aggressive form of cutaneous T-cell lymphoma with a diverse set of mutated genes. Using previously published datasets, we reanalyzed the copy number landscape of SS and detected whole genome amplifications in 20% of all SS
Publikováno v:
Molecular Therapy - Methods & Clinical Development. 25:476-489
Gene therapy is a rapidly developing field, and adeno-associated virus (AAV) is a leading viral vector candidate for therapeutic gene delivery. Newly engineered AAVs with improved abilities are now entering the clinic. It has proven challenging, howe
Autor:
Yusaku Katada, Hiromitsu Kunimi, Naho Serizawa, Deokho Lee, Kenta Kobayashi, Kazuno Negishi, Hideyuki Okano, Kenji F. Tanaka, Kazuo Tsubota, Toshihide Kurihara
Publikováno v:
Molecular Therapy - Methods & Clinical Development.
Ectopic induction of optogenetic actuators, such as channelrhodopsin, is a promising approach to restoring vision in the degenerating retina. However, the cell type-specific response of ectopic photoreception has not been well understood. It is limit
Autor:
Mathieu J.F. Crupi, Douglas J. Mahoney, Rebecca C. Auer, Sarah Tucker, Adrian Pelin, D. William Cameron, Taylor R Jamieson, Ricardo Marius, John C. Bell, Réjean Lapointe, Kyle Potts, Nikolas T. Martin, Zaid Taha, Ragunath Singaravelu, Taha Azad, Jean-François Cailhier, Joanna Poutou, Bradley Austin, Jean-Simon Diallo, Emily E.F. Brown, Jack Whelan, Christiano Tanese de Souza, Sarwat T. Khan, Reza Rezaei, Julia Petryk, Carolina S. Ilkow, Stephen Boulton, Jonathan B. Angel, Jaahnavi Dave, Xiaohong He, Abera Surendran
Publikováno v:
Molecular Therapy
The coronavirus disease 2019 (COVID-19) pandemic requires the continued development of safe, long-lasting, and efficacious vaccines for preventive responses to major outbreaks around the world, and especially in isolated and developing countries. To
Autor:
Edward J. Steele, Andrew Franklin
Publikováno v:
Trends in Genetics. 38:426-436
Somatic hypermutation at antibody loci affects both deoxyadenosine-deoxythymidine (A/T) and deoxycytidine-deoxyguanosine (C/G) pairs. Deamination of C to deoxyuridine (U) by activation-induced deaminase (AID) explains how mutation at C/G pairs is pot
Publikováno v:
Molecular Therapy. 30:2078-2091
Zika virus (ZIKV), a flavivirus associated with neurological disorders, constitutes a global health threat. During pregnancy, ZIKV traverses the placenta and causes congenital disease such as microcephaly and Guillain-Barre syndrome in newborns. To d
Autor:
Anouck Becker, Valentina Galata, Georges Pierre Schmartz, Eckart Meese, Jörn Walter, Andreas Keller, Sascha Tierling, Jacqueline Weiland, Laura Gröger, Andreas Schwiertz, Nadja Grammes, Marcus M. Unger, Gudrun Wagenpfeil, Hannah Philippeit, Nicole Ludwig, Klaus Faßbender, Jörg Spiegel
Publikováno v:
Genomics, Proteomics & Bioinformatics. 20:274-287
The composition of the gut microbiome is linked to multiple diseases, including Parkinson’s disease (PD). Bacteria producing short-chain fatty acids (SCFAs) and fecal SCFA concentrations are reduced in PD. SCFAs exert various beneficial functions i