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Publikováno v:
Pharmacol Biochem Behav
These experiments examined whether morphine and cocaine alter the balance between hippocampal and striatal memory systems measured long after drug exposure. Male rats received injections of morphine (5 mg/kg), cocaine (20 mg/kg), or saline for five c
Autor:
Paula T. Tonin, Jair C. Soares, João Quevedo, Fernanda F. Gava, Gustavo C. Dal-Pont, Samira S. Valvassori, Roger B. Varela, Camila Ferreira, Monica L. Andersen
Publikováno v:
Pharmacology Biochemistry and Behavior. 183:56-63
The present study evaluated the effects of the coadministration of lithium (Li) and Cel on inflammatory parameters in an animal model of mania induced by dextroamphetamine (D-amph). It was used Wistar rats 60 days old (250–350 g). The animals (n =
Publikováno v:
Pharmacology Biochemistry and Behavior. 183:64-71
Addiction to the psychostimulant Methamphetamine (METH) is characterised by high rates of relapse. Currently there are no approved effective pharmacotherapies for METH dependence. The neuropeptide oxytocin (OXY) potently reduces METH-seeking behaviou
Autor:
Marisela Hernández-González, Tania Molina-Jiménez, Rossana C. Zepeda, Malinalli Brianza-Padilla, Herlinda Bonilla-Jaime, Martín Jiménez-Tlapa
Publikováno v:
Pharmacology Biochemistry and Behavior. 180:83-91
Administering clomipramine during the early days of life induced several behavioral and neurochemical alterations in adult male rats, which resemble major depression disorder. The alterations included poor sexual performance, which is considered a re
Publikováno v:
Pharmacol Biochem Behav
Serotonin 5-HT(2A) receptors are expressed throughout the mesolimbic and mesocortical dopamine pathways, and manipulation of this receptor system has a profound impact on dopamine functions and dopamine-mediated behaviors. It is highly likely that 5-
Autor:
Jacob T. Krug, Matthew S. Mayes, Kathy Ayala, Aaron Ettenberg, Adam K. Klein, Erin M. Purvis, Lisette Collins, Matthew P. A. Fisher
Publikováno v:
Pharmacology Biochemistry and Behavior. 179:150-155
Bipolar illness is characterized by periods of “mania” — high energy, irritability, and increased psychomotor activation. While the neurobiological investigation of mania has been limited by the lack of reliable animal models, researchers have
Autor:
Yingxian Xiao, Amir H. Rezvani, Edward D. Levin, Corinne Wells, Kenneth J. Kellar, Susan Slade
Publikováno v:
Pharmacology Biochemistry and Behavior. 179:109-112
Sazetidine-A selectively desensitizes α4β2 nicotinic receptors and also has partial agonist effects. We have shown that subcutaneous acute and repeated injections as well as chronic infusions of sazetidine-A significantly reduce intravenous (IV) ni
Autor:
Joseph P. Huston, Maria A. de Souza Silva, Christina Antke, Anja Müller-Lutz, Markus Beu, Hans-Jörg Wittsack, Hans-Wilhelm Müller, Hubertus Hautzel, Susanne Nikolaus, Frithjof Wickrath, Gerald Antoch
Publikováno v:
Pharmacology Biochemistry and Behavior. 179:156-170
Purpose The present study assessed the influence of the NMDA receptor (R) antagonist amantadine (AMA) on cerebral dopamine D2/3R binding in relation to motor and exploratory activity in the rat. Methods D2/3R binding was determined in anaesthetized a
Autor:
Marinete Pinheiro Carrera, Breno Garone Santos, Lucas Rangel de Oliveira, João Marcos de Mello Bastos, Robert J. Carey, Richard Ian Samuels
Publikováno v:
Pharmacology Biochemistry and Behavior. 179:134-141
Morphine has substantial pro-dopamine effects and in rodents, this is expressed in behavior as increased locomotor activation. Here we administered post-trial 3 dose levels of morphine (3.0, 5.0 and 10.0 mg/kg) or vehicle either immediately or after
Publikováno v:
Pharmacology Biochemistry and Behavior. 179:89-97
The Gateway Hypothesis is based on epidemiological data and states there is a progression of drug use from use of a softer drug (e.g., nicotine) to use of a harder drug (e.g., morphine). It has been suggested that this sequence is causal and is relev