Zobrazeno 1 - 10
of 257
pro vyhledávání: '"35"'
Publikováno v:
Peptides. 26:887-891
Corticotropin releasing factor 2 receptor selective analogs of the amphibian peptide sauvagine, a member of the corticotropin releasing factor (CRF) peptide family, have therapeutic potential for the treatment of skeletal muscle atrophy. Previously,
Autor:
Giuseppe Ettore Martorana, Francesco Misiti, Michela Pezzotti, Bruno Giardina, Maria Elisabetta Clementi
Publikováno v:
The International Journal of Biochemistry & Cell Biology. 36:2066-2076
Amyloid beta-peptide, the central constituent of senile plaques in Alzheimer's disease brain, has been shown to be a source of free radical oxidative stress that may lead to neurodegeneration. In particular, it is well known that oxidation of methion
Autor:
M. Pezzotti, D. Mezzogori, Bruno Giardina, Federica Orsini, Claudio Grassi, Maria Elisabetta Clementi, Francesco Misiti, Beatrice Sampaolese
Publikováno v:
Biochemical and Biophysical Research Communications. 342:206-213
The beta amyloid (Abeta), the major protein component of brain senile plaques in Alzheimer's disease, is known to be directly responsible for the production of free radicals toxic to brain tissue and the redox state of Met-35 residue seems to play a
Autor:
D. Allan Butterfield, Ashley I. Bush
Publikováno v:
Neurobiology of Aging. 25:563-568
In the interesting debate entitled "Challenging Views of Alzheimer's Disease II," we defended the position that factors such as oxygen, the single methionine residue of amyloid beta-peptide(1-42) [Abeta(1-42)], and redox metal ions were important for
Autor:
Emmanuel Mfotie Njoya, Zhouyu Wang, Junlin He, Congqiang Xie, Chen Jianjun, Wenze Huang, Chen Yang, Siyan Liu, Li Yuzhi, Fei Wang, Yang Lingling, Shan Qian
Publikováno v:
Bioorganic & Medicinal Chemistry. 27:1087-1098
Indoleamine 2,3-dioxygenase 1 (IDO1) and tryptophan 2,3-dioxygenase (TDO) are constitutively overexpressed in many types of cancer cells and exert important immunosuppressive functions. In this article, a series of 4,6-substituted-1H-indazole derivat
Publikováno v:
Acta Biomaterialia. 80:258-268
Electrically conductive polypyrrole (PPy) is an intriguing biomaterial capable of efficient electrical interactions with biological systems. Especially, biomimetic PPy-based biomaterials incorporating biomolecules, such as hyaluronic acid (HA), can i
Publikováno v:
Journal of Psychiatric Research. 95:135-142
Brain imaging suggests that white matter abnormalities, including compromised white matter integrity in the frontal lobe, are shared across bipolar disorder (BD) and schizophrenia (SCZ). However, the precise molecular and cellular correlates remain t
Publikováno v:
International Journal of Biological Macromolecules. 102:431-437
Although membrane proteins (MPs) play crucial roles in physiological processes, information on them are insufficient, mostly due to their peculiar nature and surrounding which demand specific procedures for their extraction (using detergents) and ana
Autor:
Robert McKenna, Katye M. Poole, Linh Pham, Xi Huang, Yan Tang, Nathan E. Goldfarb, Brian P. Mahon, Wenxing Tang, Lingna Hu, Gail E. Fanucci, Kunhua Li, Ben M. Dunn, Zhanglong Liu
Publikováno v:
Journal of Biological Chemistry. 291:22741-22756
Multidrug resistance to current Food and Drug Administration-approved HIV-1 protease (PR) inhibitors drives the need to understand the fundamental mechanisms of how drug pressure-selected mutations, which are oftentimes natural polymorphisms, elicit
Publikováno v:
Redox Biology, Vol 26, Iss, Pp-(2019)
Background: Bilirubin, a by-product of haem catabolism, possesses potent endogenous antioxidant and platelet inhibitory properties. These properties may be useful in inhibiting inappropriate platelet activation and ROS production; for example, during
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::16bb903b5c62467eee3b67591da984a3
https://phaidra.univie.ac.at/o:1087547
https://phaidra.univie.ac.at/o:1087547