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Publikováno v:
European Journal of Pharmaceutical Sciences. 130:166-172
Background Moguisteine is a non-narcotic peripheral antitussive drug that has been effective and well-tolerated in clinical studies. The aim of the present work was to investigate the pharmacokinetics of moguisteine given as single or multiple doses
Autor:
Ichiro Deguchi, Masaki Takao
Publikováno v:
Journal of Stroke and Cerebrovascular Diseases. 28:354-359
Background: The choice of standard or reduced doses of direct oral anticoagulants (DOACs) depends on patients’ age, body weight, and renal function based on package instructions. Our aim was to conduct a simulation of DOAC dose using patients’ da
Publikováno v:
The American Journal of Emergency Medicine. 36:935-941
Objectives Clinical studies have indicated that transient hypotension can occur after propacetamol administration. This study aimed to analyze the hemodynamic changes after propacetamol administration in patients visiting the ED due to febrile UTI. W
Publikováno v:
Alcohol. 69:1-5
Characterization of the effects of long-term alcohol consumption on the brain would be aided by the development of behavioral assays that are relatively easy to implement in animal models of alcohol use disorders. Assessing unconditioned behaviors, s
Autor:
Teerapat Yingchoncharoen, Piyamitr Sritara, Teewin Rakyhao, Sirada Srihirun, Nathawut Sibmooh, Kanjana Sirirat, Thanaporn Sriwantana, Piyadon Sathavorasmith, Kittiphong Paiboonsukwong, Suporn Chuncharunee, Pavit Pienvichit
Publikováno v:
Nitric Oxide. 76:174-178
Pulmonary hypertension is a life-threatening complication in β-thalassemia. Inhaled sodium nitrite has vasodilatory effect on pulmonary vasculature. However, its effect on pulmonary artery pressure (PAP) in β-thalassemia subjects with pulmonary hyp
Publikováno v:
Biomedicine & Pharmacotherapy. 97:1096-1101
Alzheimer disease (AD) is a progressive dementia affecting a large proportion of the aging population. There is evidence that brain tissue in patients with AD is exposed to oxidative stress during the course of the disease. Hesperetin (Hst) is a natu
Autor:
Kapil Soni, Dinesh Dhingra
Publikováno v:
Biomedicine & Pharmacotherapy. 97:895-904
Boldine, a bioactive compound, has been reported to be neuroprotective, but its effect on learning and memory has not been explored. So, the present study was aimed to study the effect of boldine on the learning and memory of the Swiss albino male yo
Autor:
Jiafeng Zhang, Jianzhang Wu, Xiufei Yang, Dahui Chen, Wulan Li, Ziliang Fan, Peihong Qiu, Sicen Wang, Lili Huang, Shoubiao Wu, Min Zhu, Yuantie Zheng, Liping Chen, Shenghui Chu, Jiabing Wang
Publikováno v:
European Journal of Medicinal Chemistry. 143:1165-1173
Exogenous supplementation of antioxidants with ROS scavenging activity would be a potential therapy to cerebral ischemia-reperfusion injury in stroke. In the present study, a series of NDGA analogues with attenuation oxidative stress by directly scav
Publikováno v:
Drug and Alcohol Dependence. 182:98-102
Abused drugs reinforce behavior; i.e., they increase the probability of the behavior preceding their administration. Abused drugs can also act as discriminative stimuli; i.e., they can set the occasion for responding reinforced by another event. Thus
Autor:
Jason J. Rose, Sheila D. Grimes, James S. Toomey, Lutfiya Miller, Rakesh P. Patel, Charles D. Hébert, Joo-Yeun Oh
Publikováno v:
Toxicol Appl Pharmacol
Intramuscular (IM) injection of nitrite (1-10 mg/kg) confers survival benefit and protects against lung injury after exposure to chlorine gas in preclinical models. Herein, we evaluated safety/toxicity parameters after single, and repeated (once dail