Zobrazeno 1 - 9
of 9
pro vyhledávání: '"Daniel D. De Carvalho"'
Autor:
Joe McDonough, G. Lesa, Franca Ligas, Miguel Rivera, Ira Jacobs, Andrew D.J. Pearson, Malcolm A. Smith, Maureen Hattersley, Dominik Karres, Aundrietta D. Duncan, Nada Jabado, Daniel D. De Carvalho, Koen Norga, Peter C. Adamson, Donna Ludwinski, Gregory H. Reaman, Brian Gadbaw, Elizabeth Fox, Samuel C. Blackman, Mark W. Kieran, Gilles Vassal, Christian Baumann, Vickie Buenger, Delphine Heenen, Scott A. Armstrong, Michael J. Kelly, Amy Barone, Adrian Senderowicz, Franck Bourdeaut, Martha Donoghue, Tilmann Taube, Peter T.C. Ho, Lynley V. Marshall, Patrick A. Brown, Michael L. Meyers, Kimberly Stegmaier, Zariana Nikolova, Susan L. Weiner
Publikováno v:
European Journal of Cancer. 139:135-148
The fifth multistakeholder Paediatric Strategy Forum focussed on epigenetic modifier therapies for children and adolescents with cancer. As most mutations in paediatric malignancies influence chromatin-associated proteins or transcription and paediat
Publikováno v:
Immunity. 54:11-13
In a recent issue of Cell, Bowling et al. describe a mechanism by which spliceosome-targeted therapies result in intron-containing transcripts that form double-stranded RNAs (dsRNAs), thereby activating tumor antiviral signaling (viral mimicry) and d
Publikováno v:
Trends in Cell Biology. 29:31-43
During cancer initiation and progression, the somatic epigenome is broadly reprogrammed. This reprogramming can be a consequence of several processes, including altered transcriptional profiles and mutations. In addition, immune cells infiltrating th
Autor:
E.M.F.L. Domingues, M.I. de Holanda, A.M.G. Santos, T Matuck, D.S. Glasberg, Daniel D. De Carvalho, R. Curvo, Alvaro Borela, Luís Cristóvão Porto
Publikováno v:
Transplantation Proceedings. 50:728-736
Background Pretransplantation soluble CD30 (sCD30) has been shown to be a good predictor of acute rejection (AR) and graft loss. This study aimed to evaluate the effectiveness of sCD30 measured pretransplant and up to 6 months after transplantation a
Autor:
Daniel D. De Carvalho, Helen Loo Yau
Publikováno v:
STAR Protocols, Vol 2, Iss 2, Pp 100549-(2021)
STAR Protocols
STAR Protocols
Summary CD8+ T cells are key effector cells in adaptive immune responses against intracellular pathogens and cancer cells. Systemic drug treatments, like chemotherapy, may positively or negatively affect CD8+ T cell function. In this protocol, we des
Autor:
Michelle Chan-Seng-Yue, Stanley Zhou, Kerstin B. Kaufmann, Héléna Boutzen, Ken Kron, John J.Y. Lee, Naoya Takayama, Laura García-Prat, Tiago Medina, Michael D. Taylor, Juan M. Vaquerizas, John E. Dick, Noelia Díaz, Shin-ichiro Takayanagi, Mathieu Lupien, Alex Murison, Aaron Trotman-Grant, Christopher Arlidge, Sasan Zandi, Stephanie Z. Xie, Daniel D. De Carvalho, Olga I. Gan, Erwin M. Schoof
Publikováno v:
Cell Stem Cell. 28:488-501.e10
Lifelong blood production requires long-term hematopoietic stem cells (LT-HSCs), marked by stemness states involving quiescence and self-renewal, to transition into activated short-term HSCs (ST-HSCs) with reduced stemness. As few transcriptional cha
Autor:
Peter A. Jones, Gangning Liang, David Roulois, Yadong Wang, Catherine A. O’Brien, Arnavaz Danesh, Rajat Singhania, Han Han, Trevor J. Pugh, Shu Yi Shen, Daniel D. De Carvalho, Helen Loo Yau
Publikováno v:
Cell. 162(5):961-973
SummaryDNA-demethylating agents have shown clinical anti-tumor efficacy via an unknown mechanism of action. Using a combination of experimental and bioinformatics analyses in colorectal cancer cells, we demonstrate that low-dose 5-AZA-CdR targets col
Autor:
Theresa K. Kelly, Gangning Liang, Jueng Soo You, Shikhar Sharma, Xiaojing Yang, Sheng-Fang Su, Phillippa C. Taberlay, Peter A. Jones, Daniel D. De Carvalho
Publikováno v:
Cancer Cell. 21(5):655-667
SummaryCancer cells typically exhibit aberrant DNA methylation patterns that can drive malignant transformation. Whether cancer cells are dependent on these abnormal epigenetic modifications remains elusive. We used experimental and bioinformatic app
Autor:
Peter A. Jones, Daniel D. De Carvalho, Xianghong Jasmine Zhou, Phillippa C. Taberlay, Tina B. Miranda, Gangning Liang, Chun-Chi Liu, Theresa K. Kelly, Jueng Soo You
Publikováno v:
Cell. 147:1283-1294
SummaryKey regulatory genes, suppressed by Polycomb and H3K27me3, become active during normal differentiation and induced reprogramming. Using the well-characterized enhancer/promoter pair of MYOD1 as a model, we have identified a critical role for e