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Autor:
Babatunde Adekunle Murtala, Shakiru Ademola Salami, Hussein Mofomosara Salahdeen, Oluwatosin Aisha Oduyemi, Yinusa Raji
Publikováno v:
Revista Internacional de Andrología. 19:234-241
Introduction Carpolobia lutea root extract (CLRE) has been reported to enhance penile erection. However, the mechanism involved is poorly understood. We investigated in vitro mechanisms of CLRE action on contractile activity of rabbit corpus cavernos
Autor:
Guang Jia, Tiancheng Wang, Changmao Long, Pai Zheng, Shanfa Yu, Fangda Peng, Chunguang Ding, Tian Chen, Guiping Hu, Zekang Su, Yali Zhang
Publikováno v:
Toxicology Letters. 349:92-100
Hexavalent chromium (Cr(VI)) compound is considered as a common environmental and occupational pollutant due to widespread application in industry and agriculture. Cr(VI) as a carcinogen poses a serious threat to human health and the underlying mecha
Publikováno v:
Laboratory Investigation; a Journal of Technical Methods and Pathology
Uremic toxin accumulation is one possible reason for alterations in hepatic drug metabolism in patients with chronic kidney disease (CKD). However, the types of uremic toxins and underlying mechanisms are poorly understood. In this study, we report t
Publikováno v:
Journal of Pharmacological Sciences, Vol 147, Iss 1, Pp 9-17 (2021)
Schizophrenia is one of the foremost psychological illness around the world, and recent evidence shows that inflammation and oxidative stress may play a critical role in the etiology of schizophrenia. Andrographolide is a diterpenoid lactone from And
Publikováno v:
Journal of Pharmacological Sciences, Vol 147, Iss 1, Pp 27-32 (2021)
Cigarette smoking has detrimental effects on rheumatoid arthritis (RA), characterized by muscle wasting. Linalyl acetate (LA), the main component of Lavandula angustifolia Mill (lavender) oil, has anti-inflammatory properties. We investigated the det
Publikováno v:
Journal of Pharmacological Sciences, Vol 147, Iss 1, Pp 58-61 (2021)
Nicotine administration enhances object recognition memory. However, target brain regions and cellular mechanisms underlying the nicotine effects remain unclear. In mice, the novel object recognition test revealed that systemic nicotine administratio
Publikováno v:
Brain Research Bulletin. 174:92-102
Treatment of neuropathic pain (NP) resulting from nerve injury is one of the most complicated and challenging in modern practice. Pharmacological treatments for NP are not fully effectively and novel approaches are requisite. Recently, transplantatio
Publikováno v:
Journal of Pharmacological Sciences, Vol 146, Iss 4, Pp 216-225 (2021)
We aim to explore the effects of emodin and its mechanisms on renal fibrosis (RF). We firstly modeled adriamycin-induced rat RF with unilateral nephrectomy. In vivo and in vitro pharmacological experiments were performed in this study. The presence o
Publikováno v:
Brain Research Bulletin. 172:120-128
A modulatory role has been reported for the isoflavone, genistein, on voltage-gated Na+ channels in the trigeminal ganglion in vitro. However, the acute effects of genistein in vivo, particularly on nociceptive transmission in the trigeminal system,
Publikováno v:
Biochemical and Biophysical Research Communications. 561:7-13
Doxorubicin (DOX) is a broad-spectrum antineoplastic drug; however, its serious cardiotoxic side effects in inflammatory responses limit its use in clinical applications. Dopamine D1 receptor (DRD1), a G protein-coupled receptor, is crucial for the d