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Publikováno v:
Biochimica et Biophysica Acta (BBA) - Biomembranes. (12):3069-3077
We examined the volumetric behavior of the dipalmitoylphosphatidylcholine (DPPC)/cholesterol binary bilayer system with high accuracy and more cholesterol concentrations to reveal the detailed molecular states in the liquid-disordered (Ld) phase, the
Publikováno v:
Biochimica et Biophysica Acta (BBA) - Biomembranes. (9):2267-2274
The stabilizing effect of cholesterol on oxidized membranes has been studied in planar phospholipid bilayers and multilamellar 1-palmitoyl-2-linoleoyl-phosphatidylcholine vesicles also containing either 1-palmitoyl-2-glutaroyl-phosphatidylcholine or
Autor:
Robert C. MacDonald, Rumiana Koynova
Publikováno v:
Biochimica et Biophysica Acta (BBA) - Biomembranes. (10):2373-2382
A viewpoint now emerging is that a critical factor in lipid-mediated transfection (lipofection) is the structural evolution of lipoplexes upon interacting and mixing with cellular lipids. Here we report our finding that lipid mixtures mimicking biome
Autor:
Michael E. Herbig, Ursina Fromm, Annette G. Beck-Sickinger, Jeannine Leuenberger, Hans P. Merkle, Ulrike Krauss
Publikováno v:
Biochimica et Biophysica Acta (BBA) - Biomembranes. (2):197-211
Cell-penetrating peptides (CPPs) are able to translocate problematic therapeutic cargoes across cellular membranes. The exact mechanisms of translocation are still under investigation. However, evidence for endocytic uptake is increasing. We investig
Publikováno v:
Biochimica et Biophysica Acta (BBA) - Biomembranes. (2):235-243
We have investigated the membrane interactions and dynamics of a 21-mer cytotoxic model peptide that acts as an ion channel by solid-state NMR spectroscopy. To shed light on its mechanism of membrane perturbation, (31)P and (2)H NMR experiments were
Publikováno v:
Biochimica et Biophysica Acta (BBA) - Biomembranes. (1-2):84-91
Small-angle neutron scattering (SANS) measurements are performed on pure dimyristoyl phosphatidylcholine (DMPC) unilamellar vesicles (ULV) and those containing either 20 or 47 mol% cholesterol, ergosterol or lanosterol. From the SANS data, we were ab
Autor:
Jeffery B. Klauda, Kunal R. Pandit
Publikováno v:
Biochimica et Biophysica Acta (BBA) - Biomembranes. (5):1205-1210
Nearly all molecular dynamics simulations of bacterial membranes simplify the lipid bilayer by composing it of only one or two lipids. Previous attempts of developing a model E. coli membrane have used only 1-palmitoyl-2-oleoyl-sn-glycero-3-phosphoet
Autor:
Ronald G. Larson, Senthil K. Kandasamy
Publikováno v:
Biochimica et Biophysica Acta (BBA) - Biomembranes. (9):1274-1284
The effect of salt on the binding of the antimicrobial peptide magainin to POPC lipid bilayers is studied by 40–50 ns molecular dynamics simulations of a POPC bilayer in the presence of different concentrations of Na+ and Cl− ions, corresponding
Publikováno v:
Biochimica et Biophysica Acta (BBA) - Biomembranes. (5):1103-1113
The matching of hydrophobic lengths of integral membrane proteins and the surrounding lipid bilayer is an important factor that influences both structure and function of integral membrane proteins. The ion channel gramicidin is known to be uniquely s
Autor:
Ioanna Kyrikou, Constantine Poulos, Petros Chatzigeorgiou, Thomas Mavromoustakos, Maria Zervou, Nikolas P. Benetis, Kyriakos Viras
Publikováno v:
Biochimica et Biophysica Acta (BBA) - Biomembranes. (1):113-124
Existing evidence points out that the biological activity of beta-Ala-Tyr may in part related to its interactions with the cell membranes. For comparative reasons the effects of Glu were also examined using identical techniques and conditions. In ord