Zobrazeno 1 - 10
of 30
pro vyhledávání: ''
Autor:
Yohei Kawakami, Laura J. Niedernhofer, Paul D. Robbins, Tomoyuki Matsumoto, Masahiro Kurosaka, Xiaodong Mu, Johnny Huard, Ryosuke Kuroda, William S. Hambright, Koji Takayama, Takashi Yurube, Aiping Lu, Freddie H. Fu, James H. Cummins
Publikováno v:
Molecular Therapy. Methods & Clinical Development
Aging-related loss of adult stem cell function contributes to impaired tissue regeneration. Mice deficient in zinc metalloproteinase STE24 (Zmpste24−/−) exhibit premature age-related musculoskeletal pathologies similar to those observed in childr
SARS-CoV-2 infection in patients with primary mitochondrial diseases: Features and outcomes in Italy
Autor:
Anna Ardissone, Serenella Servidei, Olimpia Musumeci, Valerio Carelli, Chiara La Morgia, Maria Lucia Valentino, Michelangelo Mancuso, Caterina Garone, Guido Primiano, Costanza Lamperti, Gabriele Siciliano, Antonio Toscano, Elena Procopio
Publikováno v:
Mitochondrion
Patients with mitochondrial diseases, who usually manifest a multisystem disease, are considered potentially at-risk for a severe coronavirus disease 2019 (COVID-19). The objective of this study is to analyze the clinical features, prognosis and outc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d8d85345e9516802279ca093deccf71b
http://hdl.handle.net/11570/3203995
http://hdl.handle.net/11570/3203995
Publikováno v:
Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease. (6):862-874
The objective of this study was to elucidate the effect of partial reduction of the mitochondrial fission protein, dynamin-related protein 1 (Drp1) on mitochondrial activity and synaptic viability. Recent knockout studies of Drp1 revealed that homozy
Publikováno v:
Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease. (10):1582-1590
In kidneys, each tubular epithelial cell contains a primary cilium that protrudes from the apical surface. Ciliary dysfunction was recently linked to acute kidney injury (AKI) following renal ischemia–reperfusion. Whether ciliary regulation is a ge
Autor:
Lydia Herrmann, Thomas Arendt, Max Holzer, Michel Goedert, Isabel Hilbrich, Katharina Flach, Franziska Albrecht, Annika Arsalan-Werner, Ellen Ramminger
Publikováno v:
Biochimica et Biophysica Acta
Tau is the major microtubule-associated protein in neurons involved in microtubule stabilization in the axonal compartment. Changes in tau gene expression, alternative splicing and posttranslational modification regulate tau function and in tauopathi
Publikováno v:
Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease. (3):391-399
Oxidative stress promotes endothelial cell senescence and endothelial dysfunction, important early steps in atherogenesis. To investigate potential antioxidant effects of IGF-1 we treated human aortic endothelial cells (hAECs) with 0–100 ng/mL IGF-
Autor:
Mark A. Sussman, Nirmala Hariharan
Publikováno v:
Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease. (6):798-801
The nucleolus is a multifunctional organelle with multiple roles involving cell proliferation, growth, survival, ribosome biogenesis and stress response signaling. Alteration of nucleolar morphology and architecture signifies an early response to inc
Autor:
Darren P. Wallace
Publikováno v:
Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease. (10):1291-1300
In polycystic kidney disease (PKD), intracellular cAMP promotes cyst enlargement by stimulating mural epithelial cell proliferation and transepithelial fluid secretion. The proliferative effect of cAMP in PKD is unique in that cAMP is anti-mitogenic
Publikováno v:
Biochimica et Biophysica Acta
p38 MAPK is activated potently during cardiac ischaemia, although the precise mechanism by which it is activated is unclear. We used the isolated perfused rat heart to investigate the signalling pathways activated upstream of p38 during global cardia
Publikováno v:
Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease. (1):29-38
The abnormal production and accumulation of β-amyloid peptide (Aβ), which is produced from amyloid precursor protein (APP) by the sequential actions of β-secretase and γ-secretase, are thought to be the initial causative events in the development