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Autor:
Matteo Bordi, Valeria Cancila, Alessandra Colamatteo, Silvia Campello, Mauro Corrado, Silvia Piconese, Claudio Procaccini, Ilenia Pacella, Luca Simula, Claudio Tripodo, Vincenzo Barnaba, Martina Pigazzi, Claudia Tregnago, Giuseppe Matarese
Publikováno v:
Cell Reports
Cell Reports, Vol 25, Iss 11, Pp 3059-3073.e10 (2018)
Cell reports 25 (2018): 3059–3073.e10. doi:10.1016/j.celrep.2018.11.018
info:cnr-pdr/source/autori:Simula L.; Pacella I.; Colamatteo A.; Procaccini C.; Cancila V.; Bordi M.; Tregnago C.; Corrado M.; Pigazzi M.; Barnaba V.; Tripodo C.; Matarese G.; Piconese S.; Campello S./titolo:Drp1 Controls Effective T Cell Immune-Surveillance by Regulating T Cell Migration, Proliferation, and cMyc-Dependent Metabolic Reprogramming/doi:10.1016%2Fj.celrep.2018.11.018/rivista:Cell reports/anno:2018/pagina_da:3059/pagina_a:3073.e10/intervallo_pagine:3059–3073.e10/volume:25
Cell Reports, Vol 25, Iss 11, Pp 3059-3073.e10 (2018)
Cell reports 25 (2018): 3059–3073.e10. doi:10.1016/j.celrep.2018.11.018
info:cnr-pdr/source/autori:Simula L.; Pacella I.; Colamatteo A.; Procaccini C.; Cancila V.; Bordi M.; Tregnago C.; Corrado M.; Pigazzi M.; Barnaba V.; Tripodo C.; Matarese G.; Piconese S.; Campello S./titolo:Drp1 Controls Effective T Cell Immune-Surveillance by Regulating T Cell Migration, Proliferation, and cMyc-Dependent Metabolic Reprogramming/doi:10.1016%2Fj.celrep.2018.11.018/rivista:Cell reports/anno:2018/pagina_da:3059/pagina_a:3073.e10/intervallo_pagine:3059–3073.e10/volume:25
Summary Mitochondria are key players in the regulation of T cell biology by dynamically responding to cell needs, but how these dynamics integrate in T cells is still poorly understood. We show here that the mitochondrial pro-fission protein Drp1 fos
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a53685732c50cbef638aa82681525489
http://hdl.handle.net/10447/395012
http://hdl.handle.net/10447/395012
Autor:
Gail D. Zeevalk, Alpa H. Gautam
Publikováno v:
Biochimica et Biophysica Acta (BBA) - Bioenergetics. (7):819-828
Loss of dopamine (DA) homeostasis may be a contributing factor to cell damage in Parkinson's disease (PD). Past studies showing deleterious effects of DA on mitochondrial function, however, have been inconsistent raising questions about mitochondria
Publikováno v:
Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease. (6):862-874
The objective of this study was to elucidate the effect of partial reduction of the mitochondrial fission protein, dynamin-related protein 1 (Drp1) on mitochondrial activity and synaptic viability. Recent knockout studies of Drp1 revealed that homozy
Autor:
Gregory B. Waypa, Gabriel Loor, Navdeep S. Chandel, Robert D. Guzy, Paul T. Schumacker, Hirotaro Iwase, Terry L. Vanden Hoek, Jyothisri Kondapalli
Publikováno v:
Biochimica et Biophysica Acta (BBA) - Molecular Cell Research. (7):1382-1394
To clarify the relationship between reactive oxygen species (ROS) and cell death during ischemia–reperfusion (I/R), we studied cell death mechanisms in a cellular model of I/R. Oxidant stress during simulated ischemia was detected in the mitochondr
Autor:
Silvia Vaena de Avalos, Jacek Bielawski, Hiroshi Kitagaki, Sergei A. Novgorodov, Youssef H. Zeidan, L. Ashley Cowart, Lina M. Obeid, Nabil Matmati, Yusuf A. Hannun
Publikováno v:
Biochimica et Biophysica Acta (BBA) - Biomembranes. (11):2849-2861
The Saccharomyces cerevisiae inositol sphingolipid phospholipase C (Isc1p), a homolog of mammalian neutral sphingomyelinases, hydrolyzes complex sphingolipids to produce ceramide in vitro. Epitope-tagged Isc1p associates with the mitochondria in the
Autor:
David G. Nicholls
Publikováno v:
Biochimica et Biophysica Acta (BBA) - Bioenergetics. (11):1416-1424
The ability of isolated brain mitochondria to accumulate, store and release calcium has been extensively characterized. Extrapolation to the intact neuron led to predictions that the in situ mitochondria would reversibly accumulate Ca(2+) when the co
Publikováno v:
Biochimica et Biophysica Acta (BBA) - Molecular Cell Research. (7):1373-1381
Ca(2+) plays a central role in energy supply and demand matching in cardiomyocytes by transmitting changes in excitation-contraction coupling to mitochondrial oxidative phosphorylation. Matrix Ca(2+) is controlled primarily by the mitochondrial Ca(2+
Autor:
Lawrence I. Grossman, Icksoo Lee, Jenney Liu, Lobelia Samavati, Rabia Ramzan, Christopher Sinkler, Sebastian Vogt, Katrin Marcus, Maik Hüttemann, Gargi Mahapatra, Jeffrey W. Doan, Ashwathy Varughese, Thomas H. Sanderson, Stefan Helling, Guorong Lu
Publikováno v:
Biochimica et Biophysica Acta (BBA) - Bioenergetics. (4):598-609
Cytochrome c (Cytc) and cytochrome c oxidase (COX) catalyze the terminal reaction of the mitochondrial electron transport chain (ETC), the reduction of oxygen to water. This irreversible step is highly regulated, as indicated by the presence of tissu
Publikováno v:
Biochimica et Biophysica Acta (BBA) - Molecular Cell Research. (1):213-221
While the 3T3-L1 adipocyte model is routinely used for the study of obesity and diabetes, the mitochondrial respiratory profile in normal versus high glucose has not been examined in detail. We matured adipocytes in normal (5mM) or high (30mM) glucos
Publikováno v:
Biochimica et Biophysica Acta (BBA) - Bioenergetics. (1):150-156
Voltage-dependent anion channel (VDAC) is an abundant mitochondrial outer membrane protein. In mammals, three VDAC isoforms have been characterized. We have previously reported alterations in the function of mitochondria when assessed in situ in diff