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Autor:
Gregory B. Waypa, Gabriel Loor, Navdeep S. Chandel, Robert D. Guzy, Paul T. Schumacker, Hirotaro Iwase, Terry L. Vanden Hoek, Jyothisri Kondapalli
Publikováno v:
Biochimica et Biophysica Acta (BBA) - Molecular Cell Research. (7):1382-1394
To clarify the relationship between reactive oxygen species (ROS) and cell death during ischemia–reperfusion (I/R), we studied cell death mechanisms in a cellular model of I/R. Oxidant stress during simulated ischemia was detected in the mitochondr
Autor:
David G. Nicholls
Publikováno v:
Biochimica et Biophysica Acta (BBA) - Bioenergetics. (11):1416-1424
The ability of isolated brain mitochondria to accumulate, store and release calcium has been extensively characterized. Extrapolation to the intact neuron led to predictions that the in situ mitochondria would reversibly accumulate Ca(2+) when the co
Publikováno v:
Biochimica et Biophysica Acta (BBA) - Molecular Cell Research. (7):1373-1381
Ca(2+) plays a central role in energy supply and demand matching in cardiomyocytes by transmitting changes in excitation-contraction coupling to mitochondrial oxidative phosphorylation. Matrix Ca(2+) is controlled primarily by the mitochondrial Ca(2+
Publikováno v:
Biochimica et Biophysica Acta (BBA) - Bioenergetics. (1):150-156
Voltage-dependent anion channel (VDAC) is an abundant mitochondrial outer membrane protein. In mammals, three VDAC isoforms have been characterized. We have previously reported alterations in the function of mitochondria when assessed in situ in diff
Autor:
Lee J. Martin
Publikováno v:
Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease. (1):186-197
Effective therapies are needed for the treatment of amyotrophic lateral sclerosis (ALS), a fatal type of motor neuron disease. Morphological, biochemical, molecular genetic, and cell/animal model studies suggest that mitochondria have potentially div
Autor:
Shirley ShiDu Yan, Heng Du
Publikováno v:
Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease. (1):198-204
Amyloid beta (Abeta) plays a critical role in the pathophysiology of Alzheimer's disease. Increasing evidence indicates mitochondria as an important target of Abeta toxicity; however, the effects of Abeta toxicity on mitochondria have not yet been fu
Autor:
Thomas E. Gunter, Shey-Shing Sheu
Publikováno v:
Biochimica et Biophysica Acta (BBA) - Bioenergetics. (11):1291-1308
Mitochondria produce around 92% of the ATP used in the typical animal cell by oxidative phosphorylation using energy from their electrochemical proton gradient. Intramitochondrial free Ca(2+) concentration ([Ca(2+)](m)) has been found to be an import
Autor:
Nickolay Brustovetsky, Youyun Yang, Tatiana Brustovetsky, Tsyregma Li, Jiang Ting Zhang, Bruno Antonsson
Publikováno v:
Biochimica et Biophysica Acta (BBA) - Bioenergetics. (11):1795-1806
BAX cooperates with truncated BID (tBID) and Ca 2+ in permeabilizing the outer mitochondrial membrane (OMM) and releasing mitochondrial apoptogenic proteins. The mechanisms of this cooperation are still unclear. Here we show that in isolated brain mi