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Publikováno v:
Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease. (1):29-38
The abnormal production and accumulation of β-amyloid peptide (Aβ), which is produced from amyloid precursor protein (APP) by the sequential actions of β-secretase and γ-secretase, are thought to be the initial causative events in the development
Publikováno v:
Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease. (11):1052-1061
Mutations in the frataxin gene cause dorsal root ganglion demyelination and neurodegeneration, which leads to Friedreich's ataxia. However the consequences of frataxin depletion have not been measured in dorsal root ganglia or Schwann cells. We knock
Publikováno v:
Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease. (7):1531-1539
Respiratory Complex I deficiency is implicated in numerous degenerative and metabolic diseases. In particular, mutations in several mitochondrial DNA (mtDNA)-encoded Complex I subunits including ND4, ND5 and ND6 have been identified in several neurol