Zobrazeno 1 - 10
of 255
pro vyhledávání: ''
Autor:
Keith W. Caldecott, Zhengping Shao, Kouji Hirota, Annie A. Demin, Shan Zha, Jan Brazina, Hana Hanzlikova, Shunichi Takeda, Marek Adamowicz, Masataka Tsuda, William Gittens, Richard Hailstone, Ilona Kalasova, Hiroyuki Sasanuma
Publikováno v:
Molecular Cell
Summary Mammalian DNA base excision repair (BER) is accelerated by poly(ADP-ribose) polymerases (PARPs) and the scaffold protein XRCC1. PARPs are sensors that detect single-strand break intermediates, but the critical role of XRCC1 during BER is unkn
Autor:
Yohei Kawakami, Laura J. Niedernhofer, Paul D. Robbins, Tomoyuki Matsumoto, Masahiro Kurosaka, Xiaodong Mu, Johnny Huard, Ryosuke Kuroda, William S. Hambright, Koji Takayama, Takashi Yurube, Aiping Lu, Freddie H. Fu, James H. Cummins
Publikováno v:
Molecular Therapy. Methods & Clinical Development
Aging-related loss of adult stem cell function contributes to impaired tissue regeneration. Mice deficient in zinc metalloproteinase STE24 (Zmpste24−/−) exhibit premature age-related musculoskeletal pathologies similar to those observed in childr
Autor:
Lorenzo Botta, Fabiola Ciccosanti, Francesca Colavita, Gian Maria Fimia, Fabrizio Manetti, Martina Di Rienzo, Concetta Castilletti, Alessandra Romagnoli, Giuseppe Ippolito, Annalaura Brai, Giulia Refolo, Mauro Piacentini, Maria Rosaria Capobianchi, Chiara Agrati
Publikováno v:
Antiviral Research
COVID-19 is currently a highly pressing health threat and therapeutic strategies to mitigate the infection impact are urgently needed. Characterization of the SARS-CoV-2 interactome in infected cells may represent a powerful tool to identify cellular
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::217b3ebf478516ed3ffc9ca4461d86b2
http://hdl.handle.net/11573/1572508
http://hdl.handle.net/11573/1572508
Autor:
Nikos K. Karamanos, Maurizio Onisto, Marco Franchi, Eirini Riti, Zoi Piperigkou, Valentina Masola
Publikováno v:
Matrix Biology Plus, Vol 6, Iss, Pp 100026-(2020)
Matrix Biology Plus
Matrix Biology Plus
Cancer cell invasion into the surrounding extracellular matrix (ECM) takes place when cell-cell junctions are disrupted upon epithelial-to-mesenchymal transition (EMT). Both cancer cell-stroma and cell-cell crosstalk are essential to support the cont
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f26776a5aa1dcdff99a065ddaa8f649c
http://hdl.handle.net/11577/3352417
http://hdl.handle.net/11577/3352417
Autor:
Isabel Rivera, Sunyoung Hwang, Megan C. King, Maria I. Lioudyno, Jorge Busciglio, Jessica F. Williams, Maja Kneissig, Eduardo M. Torres, Pablo Helguera, Zuzana Storchova
Publikováno v:
CONICET Digital (CONICET)
Consejo Nacional de Investigaciones Científicas y Técnicas
instacron:CONICET
Cell Reports, Vol 29, Iss 8, Pp 2473-2488.e5 (2019)
Cell reports
Consejo Nacional de Investigaciones Científicas y Técnicas
instacron:CONICET
Cell Reports, Vol 29, Iss 8, Pp 2473-2488.e5 (2019)
Cell reports
SUMMARY An abnormal number of chromosomes, or aneuploidy, accounts for most spontaneous abortions, causes developmental defects, and is associated with aging and cancer. The molecular mechanisms by which aneuploidy disrupts cellular function remain l
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fb6bc6aa08cd1366053f252f8529913b
https://linkinghub.elsevier.com/retrieve/pii/S2211124719313737
https://linkinghub.elsevier.com/retrieve/pii/S2211124719313737
Autor:
Roberto Gambari, Elisabetta D'Aversa, Alessia Finotti, Giulia Breveglieri, Monica Borgatti, Jessica Gasparello
Publikováno v:
International Immunopharmacology
One of the major clinical features of COVID-19 is a hyperinflammatory state, which is characterized by high expression of cytokines (such as IL-6 and TNF-α), chemokines (such as IL-8) and growth factors and is associated with severe forms of COVID-1
Autor:
Ping Jiang, Xianwei Wang, Mi Wang, Zhongbao Song, Yufeng Li, Zhi-Jian Wang, Qianyu Liu, Juan Bai, Chang-Meng Xu
Publikováno v:
Virus Research
Highlights • Vimentin was a restriction factor on the replication of PCV2 in PK-15 cells. • Vimentin could interact with PCV2 Cap protein during PCV2 infection. • Vimentin affected NF-κB signaling pathways during PCV2 infection. • Vimentin u
Publikováno v:
Virus Research
The open reading frame 8 (orf8) is an accessory protein of SARS-CoV-2. It has 121 amino acids with two genotypes, orf8L and orf8S. In this study, we overexpressed the orf8L and orf8S of SARS-CoV-2 as well as the orf8b of SARS-CoV to investigate their
Publikováno v:
Biochimica et Biophysica Acta. Biomembranes
Viroporins comprise a family of non-structural proteins that play significant and diverse roles during the replication cycle of many animal viruses. Consequently, they have become promising targets for inhibitory drug and vaccine development. Structu
Autor:
Honglin Luo
Publikováno v:
Current Opinion in Virology
Highlights • Many viruses have evolved to utilize the host UPS for their own benefit. • Viruses subvert the UPS to maintain optimal level/function of viral proteins. • Viruses exploit the UPS to degrade host proteins which impede viral growth.