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Autor:
Alex Y. Strongin
Publikováno v:
Biochimica et Biophysica Acta (BBA) - Molecular Cell Research. (1):133-141
This manuscript provides an overview of the dynamic interactions which play an important role in regulating cancer cell functions. We describe and discuss, primarily, those interactions which involve membrane type-1 matrix metalloproteinase (MT1-MMP)
Publikováno v:
Biochimica et Biophysica Acta (BBA) - Molecular Cell Research. (5):881-891
HIF-1α is degraded by oxygen-dependent mechanisms but stabilized in hypoxia to form transcriptional complex HIF-1, which transactivates genes promoting cancer hallmarks. However, how HIF-1α is specifically regulated in hypoxia is poorly understood.
Publikováno v:
Biochimica et Biophysica Acta (BBA) - Bioenergetics. (6):898-910
The cbb(3)-type cytochrome c oxidases (cbb(3)-Cox) constitute the second most abundant cytochrome c oxidase (Cox) group after the mitochondrial-like aa(3)-type Cox. They are present in bacteria only, and are considered to represent a primordial innov
Publikováno v:
Biochimica et Biophysica Acta (BBA) - Molecular Cell Research. (6):1137-1143
Prohibitin 1 (PHB1), a pleiotropic protein in the cell, has been implicated in the regulation of proliferation, apoptosis, transcription, mitochondrial protein folding, and as a cell-surface receptor. This diverse array of functions of PHB1 is attrib
Autor:
Steven S. Scherer, Charles K. Abrams
Publikováno v:
Biochimica et Biophysica Acta (BBA) - Biomembranes. (8):2030-2047
CNS glia and neurons express connexins, the proteins that form gap junctions in vertebrates. We review the connexins expressed by oligodendrocytes and astrocytes, and discuss their proposed physiologic roles. Of the 21 members of the human connexin f
Autor:
Thomas Simmen, Emily M. Lynes
Publikováno v:
Biochimica et Biophysica Acta. Molecular Cell Research
The endoplasmic reticulum (ER) is the biggest organelle in most cell types, but its characterization as an organelle with a continuous membrane belies the fact that the ER is actually an assembly of several, distinct membrane domains that execute div
Autor:
Darren P. Wallace
Publikováno v:
Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease. (10):1291-1300
In polycystic kidney disease (PKD), intracellular cAMP promotes cyst enlargement by stimulating mural epithelial cell proliferation and transepithelial fluid secretion. The proliferative effect of cAMP in PKD is unique in that cAMP is anti-mitogenic
Publikováno v:
Biochimica et Biophysica Acta (BBA) - Bioenergetics. (5):491-502
Mitochondria-derived oxygen-free radical(s) are important mediators of oxidative cellular injury. It is widely hypothesized that excess NO enhances O 2 •− generated by mitochondria under certain pathological conditions. In the mitochondrial elect
Autor:
Sylvie Robine, Markus Germann, Robert G. Ramsay, Dilara Akcora, Jan R. de May, Jeffrey W. Pollard, E. Richard Stanley, Jordane Malaterre, Duy Huynh, Sally Lightowler
Publikováno v:
Stem Cell Research
Stem Cell Research, Elsevier, 2013, 10, pp.203-212
Akcora, D, Huynh, D, Lightowler, S, Germann, M, Robine, S, de May, J R, Pollard, J W, Stanley, E R, Malaterre, J & Ramsay, R G 2013, ' The CSF-1 receptor fashions the intestinal stem cell niche ', Stem Cell Research, vol. 10, no. 2, pp. 203-12 . https://doi.org/10.1016/j.scr.2012.12.001
Stem Cell Research, Elsevier, 2013, 10, pp.203-212
Akcora, D, Huynh, D, Lightowler, S, Germann, M, Robine, S, de May, J R, Pollard, J W, Stanley, E R, Malaterre, J & Ramsay, R G 2013, ' The CSF-1 receptor fashions the intestinal stem cell niche ', Stem Cell Research, vol. 10, no. 2, pp. 203-12 . https://doi.org/10.1016/j.scr.2012.12.001
Gastrointestinal (GI) homeostasis requires the action of multiple pathways. There is some controversy regarding whether small intestine (SI) Paneth cells (PCs) play a central role in orchestrating crypt architecture and their relationship with Lgr5+v
Publikováno v:
Biochimica et Biophysica Acta (BBA) - Biomembranes. (3):703-717
The ubiquitous sequence diverse 4-Toluene Sulfonate Uptake Permease (TSUP) family contains few characterized members and is believed to catalyze the transport of several sulfur-based compounds. Prokaryotic members of the TSUP family outnumber the euk