Zobrazeno 1 - 10
of 28
pro vyhledávání: ''
Autor:
Keith W. Caldecott, Zhengping Shao, Kouji Hirota, Annie A. Demin, Shan Zha, Jan Brazina, Hana Hanzlikova, Shunichi Takeda, Marek Adamowicz, Masataka Tsuda, William Gittens, Richard Hailstone, Ilona Kalasova, Hiroyuki Sasanuma
Publikováno v:
Molecular Cell
Summary Mammalian DNA base excision repair (BER) is accelerated by poly(ADP-ribose) polymerases (PARPs) and the scaffold protein XRCC1. PARPs are sensors that detect single-strand break intermediates, but the critical role of XRCC1 during BER is unkn
Autor:
Lorenzo Botta, Fabiola Ciccosanti, Francesca Colavita, Gian Maria Fimia, Fabrizio Manetti, Martina Di Rienzo, Concetta Castilletti, Alessandra Romagnoli, Giuseppe Ippolito, Annalaura Brai, Giulia Refolo, Mauro Piacentini, Maria Rosaria Capobianchi, Chiara Agrati
Publikováno v:
Antiviral Research
COVID-19 is currently a highly pressing health threat and therapeutic strategies to mitigate the infection impact are urgently needed. Characterization of the SARS-CoV-2 interactome in infected cells may represent a powerful tool to identify cellular
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::217b3ebf478516ed3ffc9ca4461d86b2
http://hdl.handle.net/11573/1572508
http://hdl.handle.net/11573/1572508
Autor:
Roberto Gambari, Elisabetta D'Aversa, Alessia Finotti, Giulia Breveglieri, Monica Borgatti, Jessica Gasparello
Publikováno v:
International Immunopharmacology
One of the major clinical features of COVID-19 is a hyperinflammatory state, which is characterized by high expression of cytokines (such as IL-6 and TNF-α), chemokines (such as IL-8) and growth factors and is associated with severe forms of COVID-1
Autor:
Ping Jiang, Xianwei Wang, Mi Wang, Zhongbao Song, Yufeng Li, Zhi-Jian Wang, Qianyu Liu, Juan Bai, Chang-Meng Xu
Publikováno v:
Virus Research
Highlights • Vimentin was a restriction factor on the replication of PCV2 in PK-15 cells. • Vimentin could interact with PCV2 Cap protein during PCV2 infection. • Vimentin affected NF-κB signaling pathways during PCV2 infection. • Vimentin u
Autor:
Xiaoling Ding, Gianpietro Dotti, Michael Scott Wood, Jeffrey J. Molldrem, Sijie Lu, Anna Sergeeva, Haven R. Garber, Eran Tallis, Gheath Alatrash, Katayoun Rezvani, Kathryn Ruisaard, Barbara Salvado, Elizabeth J. Shpall, Lisa S. St. John, Karen Clise-Dwyer, Hong He, Qing Ma
Background aims The PR1 peptide, derived from the leukemia-associated antigens proteinase 3 and neutrophil elastase, is overexpressed on HLA-A2 in acute myeloid leukemia (AML). We developed a T-cell receptor (TCR)-like monoclonal antibody (8F4) that
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bd0e4689cd2ee5c0a01c936622ea3bed
Autor:
Zhen Yang, Zhenhu Zhao, Sheng-Qi Wang, Yajun Shan, Xiaoling Yuan, Bo Dong, Zhenyu Yao, Jianyong Li, Bo Chen, Jiapei Chen, Yuwen Cong
Publikováno v:
Virus Research
SARS-CoV 3a protein was a unique protein of SARS coronavirus (SARS-CoV), which was identified in SARS-CoV infected cells and SARS patients' specimen. Recent studies revealed that 3a could interact specifically with many SARS-CoV structural proteins,
Publikováno v:
Biochimica et Biophysica Acta (BBA) - Molecular Cell Research. (2):300-310
Ezrin/radixin/moesin (ERM) proteins are membrane-cytoskeleton linkers that also have roles in signal transduction. Here we show that G protein-coupled receptor kinase 2 (GRK2) regulates membrane protrusion and cell migration during wound closure in M
Autor:
Ashley O. Warcup, Jennifer Nelson, Michael Streeter, Katalyn R. Pickett, John D. Bell, Allan M. Judd, Elizabeth Gibbons
Publikováno v:
Biochimica et Biophysica Acta (BBA) - Biomembranes. (2):887-895
Secretory phospholipase A2 exhibits much greater activity toward apoptotic versus healthy cells. Various plasma membrane changes responsible for this phenomenon have been proposed, including biophysical alterations described as “membrane fluidity
Publikováno v:
Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease. (10):1582-1590
In kidneys, each tubular epithelial cell contains a primary cilium that protrudes from the apical surface. Ciliary dysfunction was recently linked to acute kidney injury (AKI) following renal ischemia–reperfusion. Whether ciliary regulation is a ge
Autor:
Zhichao Yue, Min Young Lee, Lixia Yue, Jere Paavola, Xin Ge, Baonan Sun, Yong Woo Jung, Yongming Ren, Esra Cagavi Bozkulak, Yibing Qyang, Barbara E. Ehrlich, Simon Schliffke, Mingyu Ye, Peter J. Amos, Rong Ju
Publikováno v:
Stem Cell Research. (1):49-57
The purpose of this study is to establish a murine embryonic stem cell (mESC) line for isolation of functional ventricular cardiomyocytes (VCMs) and then to characterize the derived VCMs. By crossing the myosin light chain 2v (Mlc2v)-Cre mouse line w