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Autor:
Yohei Kawakami, Laura J. Niedernhofer, Paul D. Robbins, Tomoyuki Matsumoto, Masahiro Kurosaka, Xiaodong Mu, Johnny Huard, Ryosuke Kuroda, William S. Hambright, Koji Takayama, Takashi Yurube, Aiping Lu, Freddie H. Fu, James H. Cummins
Publikováno v:
Molecular Therapy. Methods & Clinical Development
Aging-related loss of adult stem cell function contributes to impaired tissue regeneration. Mice deficient in zinc metalloproteinase STE24 (Zmpste24−/−) exhibit premature age-related musculoskeletal pathologies similar to those observed in childr
Autor:
Ping Jiang, Xianwei Wang, Mi Wang, Zhongbao Song, Yufeng Li, Zhi-Jian Wang, Qianyu Liu, Juan Bai, Chang-Meng Xu
Publikováno v:
Virus Research
Highlights • Vimentin was a restriction factor on the replication of PCV2 in PK-15 cells. • Vimentin could interact with PCV2 Cap protein during PCV2 infection. • Vimentin affected NF-κB signaling pathways during PCV2 infection. • Vimentin u
Publikováno v:
Virus Research
Highlights • Coronavirus replication induces ER stress and the unfolded protein response (UPR). • Several coronavirus proteins modulate coronavirus-induced UPR. • During coronavirus infection, PERK is pro-apoptotic and IRE1 is anti-apoptotic.
Autor:
Brian P. Ashburner, Eric T. Cole, Amanda Korchnak, Widian F. Abi Saab, Yu Zhan, Deborah N. Chadee
Publikováno v:
Biochimica et Biophysica Acta (BBA) - Molecular Cell Research. (12):1811-1818
Mixed lineage kinase 3 (MLK3) is a mitogen activated protein kinase kinase kinase (MAP3K) that activates multiple MAPK signaling pathways. Nuclear factor kappa B (NF-kappaB) is a transcription factor that has important functions in inflammation, immu
Publikováno v:
Biochimica et Biophysica Acta (BBA) - Molecular Cell Research. (6):1489-1497
The DEAD box protein family member DDX3 was previously identified as an inhibitor of death receptor-mediated extrinsic apoptotic signaling. However, there had been no studies of the role of DDX3 in regulating the other major type of apoptosis, intrin
Autor:
Gregory B. Waypa, Gabriel Loor, Navdeep S. Chandel, Robert D. Guzy, Paul T. Schumacker, Hirotaro Iwase, Terry L. Vanden Hoek, Jyothisri Kondapalli
Publikováno v:
Biochimica et Biophysica Acta (BBA) - Molecular Cell Research. (7):1382-1394
To clarify the relationship between reactive oxygen species (ROS) and cell death during ischemia–reperfusion (I/R), we studied cell death mechanisms in a cellular model of I/R. Oxidant stress during simulated ischemia was detected in the mitochondr
Autor:
Ashley O. Warcup, Jennifer Nelson, Michael Streeter, Katalyn R. Pickett, John D. Bell, Allan M. Judd, Elizabeth Gibbons
Publikováno v:
Biochimica et Biophysica Acta (BBA) - Biomembranes. (2):887-895
Secretory phospholipase A2 exhibits much greater activity toward apoptotic versus healthy cells. Various plasma membrane changes responsible for this phenomenon have been proposed, including biophysical alterations described as “membrane fluidity
Publikováno v:
Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease. (10):1582-1590
In kidneys, each tubular epithelial cell contains a primary cilium that protrudes from the apical surface. Ciliary dysfunction was recently linked to acute kidney injury (AKI) following renal ischemia–reperfusion. Whether ciliary regulation is a ge
Publikováno v:
Biochimica et Biophysica Acta (BBA) - Molecular Cell Research. (6):971-978
Bcl-2 is the founding member of a large family of apoptosis regulating proteins. Bcl-2 is a prime target for novel therapeutics because it is elevated in many forms of cancer and contributes to cancer progression and therapy resistance based on its a
Autor:
Lawrence I. Grossman, Icksoo Lee, Jenney Liu, Lobelia Samavati, Rabia Ramzan, Christopher Sinkler, Sebastian Vogt, Katrin Marcus, Maik Hüttemann, Gargi Mahapatra, Jeffrey W. Doan, Ashwathy Varughese, Thomas H. Sanderson, Stefan Helling, Guorong Lu
Publikováno v:
Biochimica et Biophysica Acta (BBA) - Bioenergetics. (4):598-609
Cytochrome c (Cytc) and cytochrome c oxidase (COX) catalyze the terminal reaction of the mitochondrial electron transport chain (ETC), the reduction of oxygen to water. This irreversible step is highly regulated, as indicated by the presence of tissu