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Publikováno v:
Biochimica et Biophysica Acta (BBA) - Molecular Cell Research. (6):1489-1497
The DEAD box protein family member DDX3 was previously identified as an inhibitor of death receptor-mediated extrinsic apoptotic signaling. However, there had been no studies of the role of DDX3 in regulating the other major type of apoptosis, intrin
Autor:
Ashley O. Warcup, Jennifer Nelson, Michael Streeter, Katalyn R. Pickett, John D. Bell, Allan M. Judd, Elizabeth Gibbons
Publikováno v:
Biochimica et Biophysica Acta (BBA) - Biomembranes. (2):887-895
Secretory phospholipase A2 exhibits much greater activity toward apoptotic versus healthy cells. Various plasma membrane changes responsible for this phenomenon have been proposed, including biophysical alterations described as “membrane fluidity
Publikováno v:
Biochimica et Biophysica Acta (BBA) - Molecular Cell Research. (6):971-978
Bcl-2 is the founding member of a large family of apoptosis regulating proteins. Bcl-2 is a prime target for novel therapeutics because it is elevated in many forms of cancer and contributes to cancer progression and therapy resistance based on its a
Autor:
Lawrence I. Grossman, Icksoo Lee, Jenney Liu, Lobelia Samavati, Rabia Ramzan, Christopher Sinkler, Sebastian Vogt, Katrin Marcus, Maik Hüttemann, Gargi Mahapatra, Jeffrey W. Doan, Ashwathy Varughese, Thomas H. Sanderson, Stefan Helling, Guorong Lu
Publikováno v:
Biochimica et Biophysica Acta (BBA) - Bioenergetics. (4):598-609
Cytochrome c (Cytc) and cytochrome c oxidase (COX) catalyze the terminal reaction of the mitochondrial electron transport chain (ETC), the reduction of oxygen to water. This irreversible step is highly regulated, as indicated by the presence of tissu
Publikováno v:
Stem Cell Research. (3):428-441
Embryonic stem cells (ESCs) are hypersensitive to many DNA damaging agents and can rapidly undergo cell death or cell differentiation following exposure. Treatment of mouse ESCs (mESCs) with etoposide (ETO), a topoisomerase II poison, followed by a r
Publikováno v:
Biochimica et Biophysica Acta (BBA) - Molecular Cell Research. (10):2205-2210
The anti-apoptotic protein Bcl-2 is a versatile regulator of cell survival. Its interactions with its own pro-apoptotic family members are widely recognized for their role in promoting the survival of cancer cells. These interactions are thus being t
Autor:
Lee J. Martin
Publikováno v:
Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease. (1):186-197
Effective therapies are needed for the treatment of amyotrophic lateral sclerosis (ALS), a fatal type of motor neuron disease. Morphological, biochemical, molecular genetic, and cell/animal model studies suggest that mitochondria have potentially div
Autor:
Monica Chen, Vay Liang W. Go, O. Joe Hines, Gang Li, Guido Eibl, Hiroki Takahashi, Howard A. Reber, Jonathan C. King, Qing-Yi Lu, Aune Moro
Publikováno v:
Biochimica et Biophysica Acta (BBA) - Molecular Cell Research. (2):593-604
Pancreatic cancer is an exceedingly lethal disease with a five-year survival that ranks among the lowest of gastrointestinal malignancies. Part of its lethality is attributable to a generally poor response to existing chemotherapeutic regimens. New t
Autor:
Magdalena L. Circu, Tak Yee Aw
Publikováno v:
Biochimica et Biophysica Acta (BBA) - Molecular Cell Research. (10):1767-1777
Apoptosis is a highly organized form of cell death that is important for tissue homeostasis, organ development and senescence. To date, the extrinsic (death receptor mediated) and intrinsic (mitochondria derived) apoptotic pathways have been characte
Autor:
Chu Chang Chua, Xingshun Xu, Ye Xiong, Jinping Gao, Balvin H.L. Chua, Ye-Shih Ho, Hong Wang, Xuwan Liu, Ronald C. Hamdy
Publikováno v:
Biochimica et Biophysica Acta (BBA) - Molecular Cell Research. (10):2020-2029
Doxorubicin (DOX)-induced cardiotoxicity is thought to be mediated by the generation of superoxide anion radicals (superoxide) from redox cycling of DOX in cardiomyocyte mitochondria. Reduction of superoxide generates H(2)O(2), which diffuses through