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Publikováno v:
Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease. (6):862-874
The objective of this study was to elucidate the effect of partial reduction of the mitochondrial fission protein, dynamin-related protein 1 (Drp1) on mitochondrial activity and synaptic viability. Recent knockout studies of Drp1 revealed that homozy
Publikováno v:
Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease. (10):1582-1590
In kidneys, each tubular epithelial cell contains a primary cilium that protrudes from the apical surface. Ciliary dysfunction was recently linked to acute kidney injury (AKI) following renal ischemia–reperfusion. Whether ciliary regulation is a ge
Autor:
Lydia Herrmann, Thomas Arendt, Max Holzer, Michel Goedert, Isabel Hilbrich, Katharina Flach, Franziska Albrecht, Annika Arsalan-Werner, Ellen Ramminger
Publikováno v:
Biochimica et Biophysica Acta
Tau is the major microtubule-associated protein in neurons involved in microtubule stabilization in the axonal compartment. Changes in tau gene expression, alternative splicing and posttranslational modification regulate tau function and in tauopathi
Autor:
Darren P. Wallace
Publikováno v:
Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease. (10):1291-1300
In polycystic kidney disease (PKD), intracellular cAMP promotes cyst enlargement by stimulating mural epithelial cell proliferation and transepithelial fluid secretion. The proliferative effect of cAMP in PKD is unique in that cAMP is anti-mitogenic
Publikováno v:
Biochimica et Biophysica Acta
p38 MAPK is activated potently during cardiac ischaemia, although the precise mechanism by which it is activated is unclear. We used the isolated perfused rat heart to investigate the signalling pathways activated upstream of p38 during global cardia
Publikováno v:
Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease. (1):29-38
The abnormal production and accumulation of β-amyloid peptide (Aβ), which is produced from amyloid precursor protein (APP) by the sequential actions of β-secretase and γ-secretase, are thought to be the initial causative events in the development
Publikováno v:
Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease. (3):482-489
SUMOylation is a form of post-translational modification where small ubiquitin-like modifiers (SUMO) are covalently attached to target proteins to regulate their properties. SUMOylation has been demonstrated during cell stress and implicated in cellu
Publikováno v:
Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease. (10):1263-1271
Polycystic kidney disease is the defining condition of a group of common life-threatening genetic disorders characterized by the bilateral formation and progressive expansion of renal cysts that lead to end stage kidney disease. Although a large body
Autor:
Benoit I. Giasson, Elisa A. Waxman
Publikováno v:
Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease. (7):616-624
α-Synuclein is an abundant highly charged protein that is normally predominantly localized around synaptic vesicles in presynatic terminals. Although the function of this protein is still ill-defined, genetic studies have demonstrated that point mut
Publikováno v:
Biochimica et Biophysica Acta
Astrocytes play a crucial role in proper iron handling within the central nervous system. This competence can be fundamental, particularly during neuroinflammation, and neurodegenerative processes, where an increase in iron content can favor oxidativ