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Publikováno v:
Biochimica et Biophysica Acta (BBA) - Molecular Cell Research. (10):1945-1957
Mitochondria are one of the major sources of reactive oxygen species (ROS) in the cell. When exceeding the capacity of antioxidant mechanisms, ROS production may lead to different pathologies, such as ischemia–reperfusion injury, neurodegeneration,
Publikováno v:
Biochimica et Biophysica Acta (BBA) - Biomembranes. (1):15-33
G protein coupled receptors are responsible for a wide variety of signaling responses in diverse cell types. Despite major advances in the determination of structures of this class of receptors, the underlying mechanisms by which binding of different
Publikováno v:
Biochimica et Biophysica Acta (BBA) - Bioenergetics. (2):211-219
We have compared the efficacy of inhibition of the cytochrome bc 1 complexes from yeast and bovine heart mitochondria and Paracoccus denitrificans by antimycin, ilicicolin H, and funiculosin, three inhibitors that act at the quinone reduction site at
Autor:
Kimberly D. Gank, Deborah Kupferwasser, Alan J. Waring, Nannette Y. Yount, Arnold S. Bayer, Michael R. Yeaman, Robert Wiese, William Welch
Publikováno v:
Biochimica et Biophysica Acta (BBA) - Biomembranes. (3):609-619
Mammalian platelets contain an array of antimicrobial peptides, termed platelet microbicidal proteins (PMPs). Human and rabbit PMPs include known chemokines, such as platelet factor-4 (hPF-4); PMP-1 is the rabbit orthologue of hPF-4. Chemokines that
Autor:
Benoit I. Giasson, Elisa A. Waxman
Publikováno v:
Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease. (7):616-624
α-Synuclein is an abundant highly charged protein that is normally predominantly localized around synaptic vesicles in presynatic terminals. Although the function of this protein is still ill-defined, genetic studies have demonstrated that point mut
Publikováno v:
Biochimica et Biophysica Acta (BBA) - Biomembranes. (6):1321-1331
There are only a few available methods to study lateral interactions and self assembly of transmembrane helices. One of the most frequently used methods is sodium dodecylsulfate polyacrylamide gel electrophoresis (SDS-PAGE) which can report on strong
Autor:
Marco Colombini
Publikováno v:
Biochimica et Biophysica Acta (BBA) - Biomembranes. (6):1457-1465
VDAC channels exist in the mitochondrial outer membrane of all eukaryotic organisms. Of the different isoforms present in one organism, it seems that one of these is the canonical VDAC whose properties and 3D structure are highly conserved. The funda
Membrane translocation assay based on proteolytic cleavage: Application to diphtheria toxin T domain
Autor:
Alexey S. Ladokhin, Mykola V. Rodnin
Publikováno v:
Biochimica et Biophysica Acta (BBA) - Biomembranes. (1):35-40
The function of diphtheria toxin translocation (T) domain is to transfer the catalytic domain across the endosomal membrane upon acidification. The goal of this study was to develop and apply an in vitro functional assay for T domain activity, suitab
Publikováno v:
Biochimica et Biophysica Acta (BBA) - Biomembranes. (7):1781-1789
The crystal structures of the Ca(2+)- and H(+)-ATPases shed light into the membrane embedded domains involved in binding and ion translocation. Consistent with site-directed mutagenesis, these structures provided additional evidence that membrane-spa
Publikováno v:
Biochimica et Biophysica Acta. Biomembranes
Here, we review the current knowledge about viral derived membranotropic peptides, and we discuss how they may be used for many therapeutic applications. While they have been initially discovered in viral fusion proteins and have been involved in the