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Publikováno v:
Biophysical Chemistry
The Envelope (E) protein in SARS Coronavirus (CoV) is a small structural protein, incorporated as part of the envelope. A major fraction of the protein has been known to be associated with the host membranes, particularly organelles related to intrac
Autor:
Wei Li
Publikováno v:
Biophysical Chemistry
One notable feature of the SARS-CoV-2 genome, the spike (S) protein of SARS-CoV-2 has a polybasic furin cleavage site (FCS) at its S1-S2 boundary through the insertion of 12 nucleotides encoding four amino acid residues PRRA. Quite intriguingly, this
Publikováno v:
Biochimica et Biophysica Acta. Biomembranes
Membrane fusion and fission underlie two limiting steps of enveloped virus replication cycle: access to the interior of the host-cell (entry) and dissemination of viral progeny after replication (budding), respectively. These dynamic processes procee
The ORF4a protein of human coronavirus 229E functions as a viroporin that regulates viral production
Autor:
Kai Wang, Ronghua Zhang, Ke Xu, Wei Lv, Wolfgang Schwarz, Sidong Xiong, Wenjing Yu, Bing Sun, Shiqi Xie
Publikováno v:
Biochimica et Biophysica Acta. Biomembranes
In addition to a set of canonical genes, coronaviruses encode additional accessory proteins. A locus located between the spike and envelope genes is conserved in all coronaviruses and contains a complete or truncated open reading frame (ORF). Previou
Autor:
Helen M. Becker, Elangovan Gopal, Vadivel Ganapathy, Sudha Ananth, Carsten A. Wagner, Nagavedi S. Umapathy, Jaya P. Gnana-Prakasam, Puttur D. Prasad, Pamela M. Martin
Publikováno v:
Biochimica et Biophysica Acta (BBA) - Biomembranes. (11):2690-2697
Recently, we cloned two Na+-coupled lactate transporters from mouse kidney, a high-affinity transporter (SMCT1 or slc5a8) and a low-affinity transporter (SMCT2 or slc5a12). Here we report on the cloning and functional characterization of human SMCT2
Autor:
Henry M. Colecraft, Tingting Yang
Publikováno v:
Biochimica et Biophysica Acta (BBA) - Biomembranes. (7):1644-1654
RGK proteins belong to the Ras superfamily of monomeric G-proteins, and currently include four members - Rad, Rem, Rem2, and Gem/Kir. RGK proteins are broadly expressed, and are the most potent known intracellular inhibitors of high-voltage-activated
Publikováno v:
Biochimica et Biophysica Acta (BBA) - Biomembranes. (4):1091-1099
Genetically encoded FRET glucose nanosensors have proven to be useful for imaging glucose flux in HepG2 cells. However, the dynamic range of the original sensor was limited and thus it did not appear optimal for high throughput screening of siRNA pop
Publikováno v:
Biochimica et Biophysica Acta (BBA) - Molecular Cell Research. (6):971-978
Bcl-2 is the founding member of a large family of apoptosis regulating proteins. Bcl-2 is a prime target for novel therapeutics because it is elevated in many forms of cancer and contributes to cancer progression and therapy resistance based on its a
Autor:
Jonathan Bandong, Rosemarie Vithayathil, Gabriel O. Moreno, Katherine M. Chrunyk, Melanie J. Cocco, Ali Alhoshani, Gregory A. Weiss
Publikováno v:
Alhoshani, A; Vithayathil, R; Bandong, J; Chrunyk, KM; Moreno, GO; Weiss, GA; et al.(2014). Glutamate provides a key structural contact between reticulon-4 (Nogo-66) and phosphocholine. Biochimica et Biophysica Acta-Biomembranes, 1838(9), 2350-2356. doi: 10.1016/j.bbamem.2014.05.021. UC Irvine: Retrieved from: http://www.escholarship.org/uc/item/4td8v2r3
Human reticulon 4 (RTN-4) has been identified as the neurite outgrowth inhibitor (Nogo). This protein contains a span of 66 amino acids (Nogo-66) flanked by two membrane helices at the C-terminus. We previously determined the NMR structure of Nogo-66
Autor:
Steven S. Scherer, Charles K. Abrams
Publikováno v:
Biochimica et Biophysica Acta (BBA) - Biomembranes. (8):2030-2047
CNS glia and neurons express connexins, the proteins that form gap junctions in vertebrates. We review the connexins expressed by oligodendrocytes and astrocytes, and discuss their proposed physiologic roles. Of the 21 members of the human connexin f