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Autor:
Alo Ray, Manjusri Das, Hiranmoy Das, Jingwei Lu, Charles L. Shapiro, Vincent J. Pompili, Matthew Joseph, Reeva Aggarwal, Suman Kanji
Publikováno v:
Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease. (7):1071-1079
Many ovarian cancer cells express stress-related molecule MICA/B on their surface that is recognized by Vγ2Vδ2 T cells through their NKG2D receptor, which is transmitted to downstream stress-signaling pathway. However, it is yet to be established h
Publikováno v:
Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease. (12):2636-2645
Understanding of cAMP signaling has greatly improved over the past decade. The advent of live cell imaging techniques and more specific pharmacologic modulators has led to an improved understanding of the intricacies by which cAMP is able to modulate
Publikováno v:
Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease. (2):101-110
Huntington's disease (HD) is a progressive, fatal neurodegenerative disease caused by expanded polyglutamine repeats in the HD gene. HD is characterized by chorea, seizures, involuntary movements, dystonia, cognitive decline, intellectual impairment
Autor:
Coleen Ong-Justiniano, Spencer B. Gibson, Teralee R. Burton, Michelle Brown, Nicolle A. Bristow, Elizabeth S. Henson
Publikováno v:
Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease. (3):302-311
BNIP3 (Bcl-2/adenovirus E1B Nineteen Kilodalton Interacting Protein) is a pro-cell death member of the Bcl-2 family of proteins. Its expression is induced by the transcription factor Hypoxia Inducible Factor-1 (HIF-1) under conditions of low oxygen (
Publikováno v:
Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease. (3):453-474
Presenilin-associated protein (PSAP) has been identified as a mitochondrial proapoptotic protein. However, the mechanism by which PSAP induces apoptosis remains unknown. To this end, we have established an inducible expression system. Using this syst