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Publikováno v:
Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease. (6):862-874
The objective of this study was to elucidate the effect of partial reduction of the mitochondrial fission protein, dynamin-related protein 1 (Drp1) on mitochondrial activity and synaptic viability. Recent knockout studies of Drp1 revealed that homozy
Publikováno v:
Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease. (3):391-399
Oxidative stress promotes endothelial cell senescence and endothelial dysfunction, important early steps in atherogenesis. To investigate potential antioxidant effects of IGF-1 we treated human aortic endothelial cells (hAECs) with 0–100 ng/mL IGF-
Autor:
Darren P. Wallace
Publikováno v:
Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease. (10):1291-1300
In polycystic kidney disease (PKD), intracellular cAMP promotes cyst enlargement by stimulating mural epithelial cell proliferation and transepithelial fluid secretion. The proliferative effect of cAMP in PKD is unique in that cAMP is anti-mitogenic
Publikováno v:
Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease. (1):29-38
The abnormal production and accumulation of β-amyloid peptide (Aβ), which is produced from amyloid precursor protein (APP) by the sequential actions of β-secretase and γ-secretase, are thought to be the initial causative events in the development
Publikováno v:
Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease. (10):1263-1271
Polycystic kidney disease is the defining condition of a group of common life-threatening genetic disorders characterized by the bilateral formation and progressive expansion of renal cysts that lead to end stage kidney disease. Although a large body
Autor:
Benoit I. Giasson, Elisa A. Waxman
Publikováno v:
Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease. (7):616-624
α-Synuclein is an abundant highly charged protein that is normally predominantly localized around synaptic vesicles in presynatic terminals. Although the function of this protein is still ill-defined, genetic studies have demonstrated that point mut
Autor:
Lee J. Martin
Publikováno v:
Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease. (1):186-197
Effective therapies are needed for the treatment of amyotrophic lateral sclerosis (ALS), a fatal type of motor neuron disease. Morphological, biochemical, molecular genetic, and cell/animal model studies suggest that mitochondria have potentially div
Publikováno v:
Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease. (2):101-110
Huntington's disease (HD) is a progressive, fatal neurodegenerative disease caused by expanded polyglutamine repeats in the HD gene. HD is characterized by chorea, seizures, involuntary movements, dystonia, cognitive decline, intellectual impairment
Autor:
Coleen Ong-Justiniano, Spencer B. Gibson, Teralee R. Burton, Michelle Brown, Nicolle A. Bristow, Elizabeth S. Henson
Publikováno v:
Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease. (3):302-311
BNIP3 (Bcl-2/adenovirus E1B Nineteen Kilodalton Interacting Protein) is a pro-cell death member of the Bcl-2 family of proteins. Its expression is induced by the transcription factor Hypoxia Inducible Factor-1 (HIF-1) under conditions of low oxygen (
Publikováno v:
Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease. (3):453-474
Presenilin-associated protein (PSAP) has been identified as a mitochondrial proapoptotic protein. However, the mechanism by which PSAP induces apoptosis remains unknown. To this end, we have established an inducible expression system. Using this syst