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Autor:
Yohei Kawakami, Laura J. Niedernhofer, Paul D. Robbins, Tomoyuki Matsumoto, Masahiro Kurosaka, Xiaodong Mu, Johnny Huard, Ryosuke Kuroda, William S. Hambright, Koji Takayama, Takashi Yurube, Aiping Lu, Freddie H. Fu, James H. Cummins
Publikováno v:
Molecular Therapy. Methods & Clinical Development
Aging-related loss of adult stem cell function contributes to impaired tissue regeneration. Mice deficient in zinc metalloproteinase STE24 (Zmpste24−/−) exhibit premature age-related musculoskeletal pathologies similar to those observed in childr
Publikováno v:
Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease. (10):1263-1271
Polycystic kidney disease is the defining condition of a group of common life-threatening genetic disorders characterized by the bilateral formation and progressive expansion of renal cysts that lead to end stage kidney disease. Although a large body
Autor:
Coleen Ong-Justiniano, Spencer B. Gibson, Teralee R. Burton, Michelle Brown, Nicolle A. Bristow, Elizabeth S. Henson
Publikováno v:
Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease. (3):302-311
BNIP3 (Bcl-2/adenovirus E1B Nineteen Kilodalton Interacting Protein) is a pro-cell death member of the Bcl-2 family of proteins. Its expression is induced by the transcription factor Hypoxia Inducible Factor-1 (HIF-1) under conditions of low oxygen (