Zobrazeno 1 - 10
of 25
pro vyhledávání: '"Stephen R. Bloom"'
Autor:
Emma Rose McGlone, David C.D. Hope, Iona Davies, Marian Dore, Rob Goldin, Ben Jones, Zhigang Liu, Jia V. Li, Panagiotis A. Vorkas, Bernard Khoo, David Carling, James Minnion, Stephen R. Bloom, Tricia M-M. Tan
Publikováno v:
Biomedicine & Pharmacotherapy, Vol 176, Iss , Pp 116888- (2024)
Objectives: Co-agonists at the glucagon-like peptide-1 and glucagon receptors (GLP1R/GCGR) show promise as treatments for metabolic dysfunction-associated steatotic liver disease (MASLD). Although most co-agonists to date have been heavily GLP1R-bias
Externí odkaz:
https://doaj.org/article/7c277ce7faa84cd98085788d7067ad56
The vagus nerve mediates the physiological but not pharmacological effects of PYY3-36 on food intake
Autor:
Aldara Martin Alonso, Simon C. Cork, Phyllis Phuah, Benjamin Hansen, Mariana Norton, Sijing Cheng, Xiang Xu, Kinga Suba, Yue Ma, Georgina KC. Dowsett, John A. Tadross, Brian YH. Lam, Giles SH. Yeo, Herbert Herzog, Stephen R. Bloom, Myrtha Arnold, Walter Distaso, Kevin G. Murphy, Victoria Salem
Publikováno v:
Molecular Metabolism, Vol 81, Iss , Pp 101895- (2024)
Peptide YY (PYY3-36) is a post-prandially released gut hormone with potent appetite-reducing activity, the mechanism of action of which is not fully understood. Unravelling how this system physiologically regulates food intake may help unlock its the
Externí odkaz:
https://doaj.org/article/8ca434c5412d4079a5b6bb6f4eff13e9
Autor:
Emma Rose McGlone, T. Bertie Ansell, Cecilia Dunsterville, Wanling Song, David Carling, Alejandra Tomas, Stephen R. Bloom, Mark S.P. Sansom, Tricia Tan, Ben Jones
Publikováno v:
Molecular Metabolism, Vol 63, Iss , Pp 101530- (2022)
Structured abstract: Objective: To determine whether glucagon receptor (GCGR) actions are modulated by cellular cholesterol levels. Methods: We determined the effects of experimental cholesterol depletion and loading on glucagon-mediated cAMP product
Externí odkaz:
https://doaj.org/article/30118452e1cf4e4dad65c30c5ab019ba
Autor:
Emma Rose McGlone, Yusman Manchanda, Ben Jones, Phil Pickford, Asuka Inoue, David Carling, Stephen R. Bloom, Tricia Tan, Alejandra Tomas
Publikováno v:
Molecular Metabolism, Vol 53, Iss , Pp 101296- (2021)
Objectives: Receptor Activity-Modifying Protein 2 (RAMP2) is a chaperone protein which allosterically binds to and interacts with the glucagon receptor (GCGR). The aims of this study were to investigate the effects of RAMP2 on GCGR trafficking and si
Externí odkaz:
https://doaj.org/article/260c126240254cdf851adc98b9aeadbb
Autor:
Phil Pickford, Maria Lucey, Roxana-Maria Rujan, Emma Rose McGlone, Stavroula Bitsi, Fiona B. Ashford, Ivan R. Corrêa, David J. Hodson, Alejandra Tomas, Giuseppe Deganutti, Christopher A. Reynolds, Bryn M. Owen, Tricia M. Tan, James Minnion, Ben Jones, Stephen R. Bloom
Publikováno v:
Molecular Metabolism, Vol 51, Iss , Pp 101242- (2021)
Objective: Glucagon-like peptide-1 and glucagon receptor (GLP-1R/GCGR) co-agonism can maximise weight loss and improve glycaemic control in type 2 diabetes and obesity. In this study, we investigated the cellular and metabolic effects of modulating t
Externí odkaz:
https://doaj.org/article/81eb48b9c1554fad855b7b0e36385ffc
Autor:
Maria Lucey, Philip Pickford, Stavroula Bitsi, James Minnion, Jan Ungewiss, Katja Schoeneberg, Guy A. Rutter, Stephen R. Bloom, Alejandra Tomas, Ben Jones
Publikováno v:
Molecular Metabolism, Vol 37, Iss , Pp 100991- (2020)
Objective: The objective of this study was to determine how pharmacokinetically advantageous acylation impacts on glucagon-like peptide-1 receptor (GLP-1R) signal bias, trafficking, anti-hyperglycaemic efficacy, and appetite suppression. Methods: In
Externí odkaz:
https://doaj.org/article/6622263a11a0409ea4a255d09f36f3b7
Autor:
Saira Hameed, Michael Patterson, Waljit S. Dhillo, Sofia A. Rahman, Yue Ma, Christopher Holton, Apostolos Gogakos, Giles S.H. Yeo, Brian Y.H. Lam, Joseph Polex-Wolf, Wiebke Fenske, Jimmy Bell, Jelena Anastasovska, Jacques Samarut, Stephen R. Bloom, J.H. Duncan Bassett, Graham R. Williams, James V. Gardiner
Publikováno v:
Cell Reports, Vol 19, Iss 11, Pp 2202-2209 (2017)
The obesity epidemic is a significant global health issue. Improved understanding of the mechanisms that regulate appetite and body weight will provide the rationale for the design of anti-obesity therapies. Thyroid hormones play a key role in metabo
Externí odkaz:
https://doaj.org/article/d368c488aef54187b714d5c151f12af6
Autor:
Lucy Brooks, Alexander Viardot, Anastasia Tsakmaki, Emilie Stolarczyk, Jane K. Howard, Patrice D. Cani, Amandine Everard, Michelle L. Sleeth, Arianna Psichas, Jelena Anastasovskaj, Jimmy D. Bell, Kim Bell-Anderson, Charles R. Mackay, Mohammad A. Ghatei, Stephen R. Bloom, Gary Frost, Gavin A. Bewick
Publikováno v:
Molecular Metabolism, Vol 6, Iss 1, Pp 48-60 (2017)
Objective: Dietary supplementation with fermentable carbohydrate protects against body weight gain. Fermentation by the resident gut microbiota produces short-chain fatty acids, which act at free fatty acid receptor 2 (FFAR2). Our aim was to test the
Externí odkaz:
https://doaj.org/article/6e138d5bb03648ce81d279034f1eb881
Publikováno v:
Current Therapeutic Research, Vol 77, Iss C, Pp 111-115 (2015)
Aims: To investigate the effect of Glu-3 OXM-like analogues on food intake and bodyweight in male rats. Background: Oxyntomodulin (OXM) is a natural agonist at both the glucagon receptor (GCGr) and the glucagon-like peptide 1 receptor (GLP-1r), and p
Externí odkaz:
https://doaj.org/article/aaa18885f69b45769062c34a97fd582d
Autor:
Kerstin Stemmer, Stephen C. Woods, Harvey J. Grill, Jens J. Holst, Alessandro Pocai, Michael A. Nauck, Andreas Fritsche, Richard D. DiMarchi, David A. D'Alessio, Mads Tang-Christensen, Diego Perez-Tilve, Darleen A. Sandoval, Randy J. Seeley, Wolfgang Langhans, Daniel J. Drucker, Stephen R. Bloom, M.H. Tschöp, Brian Finan, Fiona M. Gribble, Timo D. Müller, Peter R. Flatt, Joel F. Habener, Juris J. Meier, Thue W. Schwartz, Frank Reimann
Publikováno v:
Molecular Metabolism, Vol 30, Iss, Pp 72-130 (2019)
Molecular Metabolism
Molecular Metabolism, 30
Mueller, T D, Finan, B, Bloom, S R, D'Alessio, D, Drucker, D J, Flatt, P R, Fritsche, A, Gribble, F, Grill, H J, Habener, J F, Holst, J J, Langhans, W, Meier, J J, Nauck, M A, Perez-Tilve, D, Pocai, A, Reimann, F, Sandoval, D A, Schwartz, T W, Seeley, R J, Stemmer, K, Tang-Christensen, M, Woods, S C, DiMarchi, R D & Tschoep, M H 2019, ' Glucagon-like peptide 1 (GLP-1) ', Molecular Metabolism, vol. 30, pp. 72-130 . https://doi.org/10.1016/j.molmet.2019.09.010
Molecular Metabolism
Molecular Metabolism, 30
Mueller, T D, Finan, B, Bloom, S R, D'Alessio, D, Drucker, D J, Flatt, P R, Fritsche, A, Gribble, F, Grill, H J, Habener, J F, Holst, J J, Langhans, W, Meier, J J, Nauck, M A, Perez-Tilve, D, Pocai, A, Reimann, F, Sandoval, D A, Schwartz, T W, Seeley, R J, Stemmer, K, Tang-Christensen, M, Woods, S C, DiMarchi, R D & Tschoep, M H 2019, ' Glucagon-like peptide 1 (GLP-1) ', Molecular Metabolism, vol. 30, pp. 72-130 . https://doi.org/10.1016/j.molmet.2019.09.010
Background: The glucagon-like peptide-1 (GLP-1) is a multifaceted hormone with broad pharmacological potential. Among the numerous metabolic effects of GLP-1 are the glucose-dependent stimulation of insulin secretion, decrease of gastric emptying, in