Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Harley I. Kornblum"'
Autor:
Alireza Sohrabi, Austin E.Y.T. Lefebvre, Mollie J. Harrison, Michael C. Condro, Talia M. Sanazzaro, Gevick Safarians, Itay Solomon, Soniya Bastola, Shadi Kordbacheh, Nadia Toh, Harley I. Kornblum, Michelle A. Digman, Stephanie K. Seidlits
Publikováno v:
Cell Reports, Vol 42, Iss 10, Pp 113175- (2023)
Summary: The mechanical properties of solid tumors influence tumor cell phenotype and the ability to invade surrounding tissues. Using bioengineered scaffolds to provide a matrix microenvironment for patient-derived glioblastoma (GBM) spheroids, this
Externí odkaz:
https://doaj.org/article/d2250eca7fe7426383653643a3dc60db
Autor:
Junfeng Bi, Atif Khan, Jun Tang, Aaron M. Armando, Sihan Wu, Wei Zhang, Ryan C. Gimple, Alex Reed, Hui Jing, Tomoyuki Koga, Ivy Tsz-Lo Wong, Yuchao Gu, Shunichiro Miki, Huijun Yang, Briana Prager, Ellis J. Curtis, Derek A. Wainwright, Frank B. Furnari, Jeremy N. Rich, Timothy F. Cloughesy, Harley I. Kornblum, Oswald Quehenberger, Andrey Rzhetsky, Benjamin F. Cravatt, Paul S. Mischel
Publikováno v:
Cell Reports, Vol 37, Iss 5, Pp 109957- (2021)
Summary: The highly lethal brain cancer glioblastoma (GBM) poses a daunting challenge because the blood-brain barrier renders potentially druggable amplified or mutated oncoproteins relatively inaccessible. Here, we identify sphingomyelin phosphodies
Externí odkaz:
https://doaj.org/article/8516b7196aa84c49af33aefb9f94a103
Autor:
Jantzen Sperry, Michael C. Condro, Lea Guo, Daniel Braas, Nathan Vanderveer-Harris, Kristen K.O. Kim, Whitney B. Pope, Ajit S. Divakaruni, Albert Lai, Heather Christofk, Maria G. Castro, Pedro R. Lowenstein, Janel E. Le Belle, Harley I. Kornblum
Publikováno v:
iScience, Vol 23, Iss 9, Pp 101453- (2020)
Summary: Glioblastoma (GBM) metabolism has traditionally been characterized by a primary dependence on aerobic glycolysis, prompting the use of the ketogenic diet (KD) as a potential therapy. In this study we evaluated the effectiveness of the KD in
Externí odkaz:
https://doaj.org/article/c408bc708ce74fd297a8a89e0dcb76f3
Autor:
Janel E. Le Belle, Jantzen Sperry, Amy Ngo, Yasmin Ghochani, Dan R. Laks, Manuel López-Aranda, Alcino J. Silva, Harley I. Kornblum
Publikováno v:
Stem Cell Reports, Vol 3, Iss 5, Pp 725-734 (2014)
A period of mild brain overgrowth with an unknown etiology has been identified as one of the most common phenotypes in autism. Here, we test the hypothesis that maternal inflammation during critical periods of embryonic development can cause brain ov
Externí odkaz:
https://doaj.org/article/42395dca1d2448a78b8616704b74c65f
Autor:
Gretchen M. Thomsen, Janel E. Le Belle, Jessica A. Harnisch, Whitney S. Mc Donald, David A. Hovda, Michael V. Sofroniew, Harley I. Kornblum, Neil G. Harris
Publikováno v:
Stem Cell Research, Vol 13, Iss 1, Pp 48-60 (2014)
The acute response of the rodent subventricular zone (SVZ) to traumatic brain injury (TBI) involves a physical expansion through increased cell proliferation. However, the cellular underpinnings of these changes are not well understood. Our analyses
Externí odkaz:
https://doaj.org/article/84e5beb0a74b458386f70d0c04ebd133
Autor:
Gary W. Mathern, James K. Pretorius, Harley I. Kornblum, Delia Mendoza, Alana Lozada, Joao P. Leite, Leila Chimelli, Donald E. Born, Itzhak Fried, Americo C. Sakamoto, Joao A. Assirati, Warwick J. Peacock, George A. Ojemann, P.David Adelson
Publikováno v:
Neurobiology of Disease, Vol 5, Iss 3, Pp 151-176 (1998)
This study determined whether hippocampal kainate (KA) receptor mRNA levels were increased or decreased in temporal lobe epilepsy patients compared with nonseizure autopsies. Hippocampal sclerosis (HS;n= 17), nonsclerosis (non-HS;n= 11), and autopsy
Externí odkaz:
https://doaj.org/article/b731394ad3e94018b3ad02a2fb55b573
Autor:
Manmeet S. Ahluwalia, Mohammed Ahmed, Mohsen Akbari, Alvaro G. Alvarado, Meitham Amereh, Kartik Angara, Ali S. Arbab, David M. Ashley, Ryan J. Atkins, Husam A. Babikir, Stephen J. Bagley, Kristen A. Batich, Sabrina Battista, Giacomo Casati, Maria Luigia Censullo, Laura Cerchia, Niall M. Corcoran, Alex Cordero, Sunit Das, Sanaz Dastghaib, Xavier Declèves, Cecilia Diceglie, Nicholas J. Dunne, Adam Eljarrah, Jawad Fares, Monica Fedele, Henry S. Friedman, Marina Gergues, Saeid Ghavami, Laura Giunti, Milena Guidi, Kshama Gupta, Sima Hajiahmadi, Akira Hara, Christopher M. Hovens, Ahmed Idbaih, Anna Lisa Iorio, Toru Iwama, Mohammed Jaloudi, M. Janaki Ramaiah, Lynn Jena, David Olayinka Kamson, Deepak Kanojia, Mustafa Khasraw, Harmon Singh Khela, Takamasa Kinoshita, Gaspar J. Kitange, Harley I. Kornblum, Vijay Kumar Kutala, John Laterra, Hakho Lee, Sang Y. Lee, Maciej S. Lesniak, James K. Liu, Alessia Lo Dico, Kirsten Ludwig, William T. Maich, Theo Mantamadiotis, Cristina Martelli, Tarik F. Massoud, Helen O. McCarthy, Masafumi Miyai, Shaik Mohammad Naushad, Pooneh Mokarram, Ahmed Musah-Eroje, Sree Deepthi Muthukrishnan, Arutselvan Natarajan, Marina Nikolopoulos, Luisa Ottobrini, Ramasamy Paulmurugan, David Prado, Pranela Rameshwar, Yasmeen Rauf, Rajasekhar Reddy Manyam, Barbara Rombi, Sabra K. Salim, Daniela Salvatore, John H. Sampson, Iacopo Sardi, Neil Savage, Vibha Harindra Savanur, Amir Seyfoori, Zahra Shahsavari, Huilin Shao, Shahla Shojaei, Sheila K. Singh, Georgios Solomou, Laura A. Sordillo, Peter P. Sordillo, Stanley S. Stylli, Uday Kumar Sukumar, Hiroyuki Tomita, Arata Tomiyama, Ilya Ulasov, Chitra Venugopal, Maite Verreault, Colin Watts, Chi Yan Wong, Mozhdeh Zamani
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::21721ef1f3753405fa0dfad9c29b9802
https://doi.org/10.1016/b978-0-12-821567-8.09988-7
https://doi.org/10.1016/b978-0-12-821567-8.09988-7
Gliomas are the most malignant and aggressive form of brain tumors, and account for the majority of brain cancer-related deaths. Malignant gliomas, including glioblastoma are treated with radiation and temozolomide, with only a minor benefit in survi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::11d6dee60c56acfd42b0d5d3f8cfeb59
https://doi.org/10.1016/b978-0-12-821567-8.00020-8
https://doi.org/10.1016/b978-0-12-821567-8.00020-8
Autor:
Warwick J. Peacock, Gary W. Mathern, George A. Ojemann, Leila Chimelli, Itzhak Fried, Alana Lozada, Donald E. Born, Américo Ceiki Sakamoto, João Pereira Leite, João Alberto Assirati, Delia Mendoza, James K. Pretorius, P. David Adelson, Harley I. Kornblum
Publikováno v:
Neurobiology of Disease, Vol 5, Iss 3, Pp 151-176 (1998)
This study determined whether hippocampal kainate (KA) receptor mRNA levels were increased or decreased in temporal lobe epilepsy patients compared with nonseizure autopsies. Hippocampal sclerosis (HS; n = 17), nonsclerosis (non-HS; n = 11), and auto
Autor:
Simona Raffioni, Francis M. Leslie, Ralph A. Bradshaw, Michael Blaber, Kathleen P. Cavanaugh, David Eveleth, Harley I. Kornblum, Joseph G. Altin
Publisher Summary The identification of a number of growth factors and hormones that have well-defined activities outside the nervous system as neurotrophic agents in both the peripheral nervous system and central nervous system is an example of the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0f975a445be9491947b8cdd618f8523e
https://doi.org/10.1016/s0079-6123(08)63174-x
https://doi.org/10.1016/s0079-6123(08)63174-x